Results 1 to 10 of about 23,689 (146)
Decoding histone ubiquitylation
Frontiers in Cell and Developmental Biology, 2022 Histone ubiquitylation is a critical part of both active and repressed transcriptional states, and lies at the heart of DNA damage repair signaling.
Jennifer J. Chen +2 more
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Construction of a robust sepsis prognostic classifier based on E3 ubiquitin ligase-related genes [PDF]
Frontiers in Molecular BiosciencesSepsis is a life-threatening disease with high mortality and one of the leading causes of death worldwide. Although studies have shown that ubiquitylation is closely related to the occurrence and development of sepsis, the prognostic and diagnostic value
Haiyan Xue +4 more
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Aging and diet alter the protein ubiquitylation landscape in the mouse brain [PDF]
Nature CommunicationsPost-translational modifications (PTMs) regulate protein homeostasis, but how aging impacts PTMs remains unclear. Here, we used mass spectrometry to reveal changes in hundreds of protein ubiquitylation, acetylation, and phosphorylation sites in the mouse
Antonio Marino +7 more
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ELISA Based Protein Ubiquitylation Measurement
Bio-Protocol, 2019 Ubiquitylation is a common post-translational modification of cellular proteins that results in proteasomal and lysosomal degradations. Ubiquitylation is generally measured by methods such as immunoblotting using anti-ubiquitin antibodies after isolating
Yuka Kamada +2 more
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Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice
Lupus Science and Medicine, 2023 Objective The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse.Methods ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a diet
Philip Cohen +4 more
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IUBMB Life, 2012 AbstractThe Inhibitor of apoptosis (IAP) proteins are key negative regulators of cell death, whose amplification has been correlated with tumor progression. Due to the presence of a RING domain, IAP proteins are classed as ubiquitin ligases and regulate cell survival by orchestrating a variety of ubiquitin modifications.
Rebecca, Feltham +2 more
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IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
Nature Communications, 2021 Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL ...
Olivia J. James +7 more
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Wellcome Open Research, 2020 Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively.
Kevin Z.L. Wu +9 more
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Scientific Reports, 2021 Tonne–Kalscheuer syndrome (TOKAS) is an X-linked intellectual disability syndrome associated with variable clinical features including craniofacial abnormalities, hypogenitalism and diaphragmatic hernia.
Francisco Bustos +8 more
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eLife, 2020 The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase.
Tom D Deegan +4 more
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