Results 91 to 100 of about 23,719 (175)

Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation

The FEBS Journal, Volume 293, Issue 5, Page 1285-1296, March 2026.
This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley   +1 more source

BLAP-tags, TUBEs and DUB-Chips: Combined novel technologies will advance molecular epithelial physiology

Frontiers in Physiology, 2012
The field of ubiquitylation and dubiquitylation of proteins in molecular physiology is growing at a rapid rate. Our understanding of molecular physiology of these processes may become limited by the advancement of technologies that scientists can employ.
Kirk L Hamilton
doaj   +1 more source

Regulation of Autophagy and Metabolism in Hepatocellular Carcinoma: Involvement of Wnt‐β‐Catenin Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Most cancer cells rely on aerobic glycolysis to support uncontrolled proliferation and evade apoptosis and switch to glutamine metabolism to survive under hypoxic conditions. In hepatocellular carcinoma (HCC), the Wnt/β‐catenin pathway acts as a critical driver of metabolic reprogramming and stemness, primarily by enhancing aerobic glycolysis ...
Sanjit K. Roy, Rashmi Srivastava, Nancy Landry, Shivam Srivastava, Anju Shrivastava, Rakesh K. Srivastava   +5 more
wiley   +1 more source

Finding balance: the dynamic interplay between H3K27me3 writers and erasers in regulating environmental plasticity and memory

New Phytologist, Volume 249, Issue 5, Page 2241-2250, March 2026.
Summary Subject to an ever‐changing world, plants must respond to harmful conditions and environmental fluctuations. Their evolutionary success can be attributed to their plasticity in both perceiving and integrating these variations to facilitate adaptation.
Rory Osborne
wiley   +1 more source

Targeted dephosphorylation of TFEB promotes its nuclear translocation

iScience
Summary: Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localized to the cytoplasm ...
Jin-Feng Zhao, Natalia Shpiro, Gajanan Sathe, Abigail Brewer, Thomas J. Macartney, Nicola T. Wood, Florentina Negoita, Kei Sakamoto, Gopal P. Sapkota   +8 more
doaj   +1 more source

Ubiquitylation as a rheostat for TCR signaling: from targeted approaches towards global profiling.

Frontiers in Immunology, 2015
T cell receptor (TCR) signaling must be precisely tuned to limit collateral damage and prevent reactivity to self, while still allowing robust protective immune responses that control pathogen invasion.
Paula M Oliver, Claire eOleary, Emma eLewis   +2 more
doaj   +1 more source

Structural mass spectrometry techniques for characterisation of plant and algal proteins

The Plant Journal, Volume 125, Issue 6, March 2026.
SUMMARY Structural biology can offer valuable insights into the mechanisms and functions of key proteins within plant molecular and cellular systems. However, plant proteins present several specific challenges for structural analysis, including difficulties in expression and purification, significant intrinsic disorder, and extensive post‐translational
Rhiannon Durant, Dušan Živković, Jani R. Bolla   +2 more
wiley   +1 more source

Insights into Gli Factors Ubiquitylation Methods

, 2015
The Hedgehog (Hh) signaling pathway governs cell growth and tissue development. Malfunctioning of several Hh pathway components, including the key transcriptional effector Gli proteins, is responsible for the onset of several tumors. Gli proteins activity is finely controlled by multilayered regulatory mechanisms, the most prominent of which is their ...
INFANTE, PAOLA, ALFONSI, ROMINA, DI MARCOTULLIO, LUCIA   +2 more
openaire   +3 more sources

Identification of E3 Ubiquitin Ligase Substrates Using Biotin Ligase-Based Proximity Labeling Approaches

Biomedicines
Ubiquitylation is a post-translational modification originally identified as the first step in protein degradation by the ubiquitin–proteasome system. Ubiquitylation is also known to regulate many cellular processes without degrading the ubiquitylated ...
Koji Matsuhisa, Shinya Sato, Masayuki Kaneko   +2 more
doaj   +1 more source

K63-linked ubiquitylation of RMI1 by RNF8 is essential to its recruitment to stalled forks. [PDF]

Cell Mol Life Sci
Arun R, Kumbhakar S, Kaur T, Kaur S, Sengupta S.   +4 more
europepmc   +1 more source