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Rap1 activity and localization is regulated by Rab40/CRL5 facilitated mono-ubiquitylation. [PDF]
Neumann A +3 more
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Correction: Reciprocal deregulation of NKX3.1 and AURKA axis in castration-resistant prostate cancer and NEPC models. [PDF]
Sooreshjani MA +3 more
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Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability. [PDF]
Dürauer S +18 more
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Integrative Omics Reveals Glutamine Catabolism-Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading. [PDF]
Ding Y +14 more
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Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization. [PDF]
Perrard J, Gao K, Ring K, Smith S.
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Boosting CAR T-cell efficacy by blocking proteasomal degradation of membrane antigens.
Rieger L +32 more
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Chemical chromatin ubiquitylation
Current Opinion in Chemical Biology, 2018Histone modifications dynamically regulate chromatin structure and function, thereby mediating many processes that require access to DNA. Chemical protein synthesis has emerged as a powerful approach for generating homogeneously modified histone analogues in workable amounts for subsequent incorporation into nucleosome arrays for biochemical ...
Muhammad, Jbara +3 more
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IAPs, RINGs and ubiquitylation
Nature Reviews Molecular Cell Biology, 2005The inhibitor of apoptosis (IAP) proteins all contain one or more baculoviral IAP repeat motifs, through which they interact with various other proteins. Many IAPs also have another zinc-binding motif, the RING domain, which can recruit E2 ubiquitin-conjugating enzymes and catalyse the transfer of ubiquitin onto target proteins.
Vaux, David L., Silke, John.
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