Results 11 to 20 of about 23,719 (175)
FBXW7 Targets the SPT6-ΔNp63 Axis for Degradation to Inhibit Esophageal Tumorigenesis Induced by 4-Nitroquinoline N-Oxide. [PDF]
MedComm (2020)In normal cells, FBXW7 promotes ubiquitylation and degradation of SPT6 and ΔNp63 to keep their pro‐proliferative functions under control. During esophageal tumorigenesis, FBXW7 is inactivated by mutations or deletion, leading to the accumulation of SPT6 and ΔNp63, with ΔNp63 also being up‐regulated by SPT6.
Zhang J, Yin L, You X, Xiong X, Sun Y.
europepmc +2 more sources
Open Biology, 2022 Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways.
Poonam Kakade +14 more
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Oncoprotein ubiquitylation [PDF]
Cell Cycle, 2014 Many molecular events are terminated by rapid protein degradation via the ubiquitin–proteasome system. Most target proteins are recognized by E3 ubiquitin ligases, often after specific protein modifications, leading to their poly-ubiquitylation and subsequent degradation by the proteasome.
Welcker, Markus, Clurman, Bruce E
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Ubiquitylation and cell signaling [PDF]
The EMBO Journal, 2005 Ubiquitylation is an emerging mechanism implicated in a variety of nonproteolytic cellular functions. The attachment of a single ubiquitin (Ub) or poly-Ub (lysine 63) chains to proteins control gene transcription, DNA repair and replication, intracellular trafficking and virus budding.
Kaisa, Haglund, Ivan, Dikic
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Wellcome Open Research, 2019 Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively.
Kevin Z.L. Wu +9 more
doaj +1 more source
Platelet Ubiquitylation—It's Everywhere [PDF]
Thrombosis and Haemostasis, 2018 A decade ago, the use of omics—the global analysis of biological or molecular systems—in vascular biology was highlighted in a major review by Rüegg et al in Thrombosis and Haemostasis.[1] The relative value of these new emerging techniques was considered complementary and synergistic to traditional, more focused scientific approaches, notwithstanding ...
Gardiner, Elizabeth, Andrews, Robert K.
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BRCA1-Mediated Ubiquitylation [PDF]
Cell Cycle, 2006 The BRCA1 tumour suppressor and its heterodimeric partner BARD1 play crucial roles in coordinating cellular responses to DNA damage. Evidence also implicates these proteins in transcriptional regulation, cell cycle progression and meiotic sex chromosome inactivation, but their mode of action remains elusive.
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Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor
Lupus Science and Medicine, 2021 Objective We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later.
Philip Cohen +5 more
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Another Facet of Ubiquitylation: Death [PDF]
Journal of Molecular Cell Biology, 2009 Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequestosome-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell death.
Wong, Wendy., Silke, John.
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Reversible ubiquitylation in plant biology [PDF]
Frontiers in Plant Science, 2014 Reversible ubiquitylation plays an important regulatory role in almost all aspects of cellular and organismal processes in plants. Its pervasive regulatory role in plant biology is primarily due to the involvement of a large set of ubiquitin system constituents (encoded by approximately 6% Arabidopsis genome), the huge number of important cellular ...
Hongyong, Fu +2 more
openaire +5 more sources