Results 1 to 10 of about 7,973 (164)

Pharmacokinetics and Pharmacogenetics of Dabigatran

Рациональная фармакотерапия в кардиологии, 2021
Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova, V. S. Dobrodeeva, M. M. Petrova, R. F. Nasyrova, N. A. Shnayder   +4 more
doaj   +1 more source

Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues

Pharmacology Research & Perspectives, 2023
UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play important roles in the detoxification of endogenous and exogenous substrates.
Lucas Zhou, Abelardo D. Montalvo, Joseph M. Collins, Danxin Wang   +3 more
doaj   +1 more source

Population genetic research of the mutation in ugt1a1 gene associated with reduced activity of liver UDP-glucuronosyltransferase A1

Фундаментальная и клиническая медицина, 2020
Aim. To explore allele and genotype frequencies of the rs8175347 polymorphism within the UGT1A1 gene in Kemerovo Region. Materials and Methods. The study sample included 64 male and 68 female inhabitants of the Kemerovo Region.
A. N. Volkov
doaj   +1 more source

Piscine UDP-glucuronosyltransferase 1B [PDF]

Aquatic Toxicology, 2007
Glucuronidation is an important detoxification pathway for organic pollutants in fish. We report here the isolation and characterisation of UDP-glucuronosyltransferases (UGT) genes from the closely related marine flatfish, plaice (Pleuronectes platessa) and flounder (Platichthys flesus).
Leaver, Michael, Wright, Joy, Hodgson, Paul, Boukouvala, Evridiki, George, Stephen   +4 more
openaire   +3 more sources

Bilirubin metabolism and UDP‐glucuronosyltransferase 1A1 variants in Asians: Pathogenic implications and therapeutic response

Kaohsiung Journal of Medical Sciences, 2022
In the Asian general population, at least six single‐nucleotide variants (SNVs) in the UDP‐glucuronosyltransferase (UGT) 1A1 gene have been identified: −3279T>G, −53A(TA)6TAA>A(TA)7TAA, 211G>A, 686C>A, 1091C>T, and 1456T>G.
May‐Jen Huang, Pei‐Lain Chen, Ching‐Shan Huang   +2 more
doaj   +1 more source

UDP-glucuronosyltransferase is involved in susceptibility of Chironomus kiiensis Tokunaga, 1936 (Diptera: Chironomidae) to insecticides

Ecotoxicology and Environmental Safety, 2023
UDP-glucuronosyltransferases (UGTs) could transform various exogenous and endogenous compounds, which help detoxification of pesticides in insects. To investigate the role of UGTs in the detoxification metabolism of insecticides in Chironomus kiiensis ...
Chengcheng Fan, Zexiao Cui, Tianying Yang, Lili Sun, Chuanwang Cao   +4 more
doaj   +1 more source

Biosynthesis of hydroxyl-linked glucuronides of short-chain bile acids by rat liver 3-hydroxysteroid UDP-glucuronosyltransferase.

Journal of Lipid Research, 1988
Microsomal preparations from livers of Sprague-Dawley rats catalyze the glucuronidation of 3 alpha-hydroxy-5 beta-H (3 alpha, 5 beta) short-chain bile acids (C20-C23), predominantly at the hydroxyl group, while the glucuronidation of 3 beta, 5 beta short-
A Radominska, M D Green, P Zimniak, R Lester, T R Tephly   +4 more
doaj   +1 more source

Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) [PDF]

, 2013
This item is under embargo for a period of 12 months from the date of publication, in accordance with the publisher's policy. ‘This is the peer reviewed version of the following article: Knights, K. M., Rowland, A. and Miners, J. O.
Knights, Kathleen Mary, Miners, John Oliver, Rowland, Andrew   +2 more
core   +1 more source

Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases

Antioxidants, 2021
2,3-Dehydrosilybin A and 2,3-dehydrosilybin B are a pair of enantiomers formed by the oxidation of the natural flavonolignans silybin A and silybin B, respectively.
Jiří Vrba, Barbora Papoušková, Kateřina Lněničková, Pavel Kosina, Vladimír Křen, Jitka Ulrichová   +5 more
doaj   +1 more source

A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines [PDF]

, 2017
published_or_final_versio
Cheung, F, Feng, Y, HONG, M, Huang, J, LI, S, Tan, HY, Wang, N   +6 more
core   +1 more source