Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metabolites. [PDF]
Drug Metab Dispos, 2021 The UDP-glucuronosyltransferase (UGT) family of enzymes play a central role in the metabolism and detoxification of a wide range of endogenous and exogenous compounds.
Nasrin S +5 more
europepmc +2 more sources
Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues [PDF]
Pharmacology Research & Perspectives, 2023 UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play important roles in the detoxification of endogenous and exogenous substrates.
Lucas Zhou +3 more
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The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human Diseases. [PDF]
J Pers Med, 2021 UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that metabolize endogenous fatty acids such as arachidonic acid metabolites, as well as many prescription drugs, such as opioids, antiepileptics, and antiviral drugs.
Jarrar Y, Lee SJ.
europepmc +2 more sources
Bilirubin metabolism and UDP‐glucuronosyltransferase 1A1 variants in Asians: Pathogenic implications and therapeutic response [PDF]
Kaohsiung Journal of Medical Sciences, 2022 In the Asian general population, at least six single‐nucleotide variants (SNVs) in the UDP‐glucuronosyltransferase (UGT) 1A1 gene have been identified: −3279T>G, −53A(TA)6TAA>A(TA)7TAA, 211G>A, 686C>A, 1091C>T, and 1456T>G.
May‐Jen Huang +2 more
doaj +2 more sources
UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression. [PDF]
Br J Pharmacol, 2020 Cytochrome P450 (CYP, P450) 3A4 is involved in the metabolism of 50% of drugs and its catalytic activity in vivo is not explained only by hepatic expression levels.
Miyauchi Y +6 more
europepmc +2 more sources
Effect of Efavirenz on UDP-Glucuronosyltransferase 1A1, 1A4, 1A6, and 1A9 Activities in Human Liver Microsomes [PDF]
Molecules, 2012 Efavirenz is a non-nucleoside reverse transcriptase inhibitor used for the treatment of human immunodeficiency virus type 1 infections. Drug interactions of efavirenz have been reported due to in vitro inhibition of CYP2C9, CYP2C19, CYP3A4, and UDP ...
Hye Suk Lee +4 more
doaj +2 more sources
Machine learning and structure-based modeling for the prediction of UDP-glucuronosyltransferase inhibition [PDF]
iScience, 2022 Summary: UDP-glucuronosyltransferases (UGTs) are responsible for 35% of the phase II drug metabolism. In this study, we focused on UGT1A1, which is a key UGT isoform.
Balint Dudas +4 more
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Age-dependent Hepatic UDP-glucuronosyltransferase Gene Expression and Activity in Children
Frontiers in Pharmacology, 2016 UDP-glucuronosyltransferases (UGTs) are important phase II drug metabolism enzymes. The aim of this study was to explore the relationship between age and changes in mRNA expression and activity of major human hepatic UGTs, as well as to understand the ...
Elizabeth Neumann +6 more
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Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria) [PDF]
Animals, 2022 UDP-glucuronosyltransferases (UGTs) are one of the most important enzymes for xenobiotic metabolism or detoxification. Through duplication and loss of genes, mammals evolved the species-specific variety of UGT isoforms. Among mammals, Carnivora is one of
Mitsuki Kondo +4 more
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Effect of UDP‐glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome [PDF]
Kaohsiung Journal of Medical Sciences, 2019 Variations at the six nucleotides −3279 (T > G), −53 (A[TA]6TAA > A[TA]7TAA), 211 (G > A), 686 (C > A), 1091 (C > T), and 1456 (T > G) in the UDP‐glucuronosyltransferase 1A1 (UGT1A1) gene were determined in 178 Taiwanese patients with Gilbert's syndrome ...
May‐Jen Huang +5 more
doaj +2 more sources