Results 121 to 130 of about 7,973 (164)

Catechol O-Methyltransferase : Glucuronidation of Inhibitors and Methylation of Substrates [PDF]

, 2000
Lautala, Pia
core  

Functional consequences of urinary bladder cancer risk variants [PDF]

, 2013
Selinski, Silvia
core  

International Evaluation of Research and Doctoral Training at the University of Helsinki 2005-2010 : RC-Specific Evaluation of MEDCHEMBIO - Medicinal Chemistry and Biochemistry Research Group [PDF]

, 2012

core  

Anabolic steroid glucuronides : Enzyme-assisted synthesis and liquid chromatographic-mass spectrometric analysis [PDF]

, 2003
Kuuranne, Tiia
core  

Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study [PDF]

, 2005
Sarah J Lord, Wendy J Mack, David Van Den Berg, Malcolm C Pike, Sue A Ingles, Christopher A Haiman, Wei Wang, Yuri R Parisky, Howard N Hodis, Giske Ursin   +9 more
core   +1 more source

Genetic Polymorphism of UDP-Glucuronosyltransferase

, 2017
Mehboob, Huma, Tahir, Imtiaz Mahmood, Iqbal, Tahira, Akhter, Naheed, Munir, Naveed, Riaz, Muhammad   +5 more
openaire   +3 more sources

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UDP-Glucuronosyltransferases

Current Drug Metabolism, 2000
Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen ...
C D, King, G R, Rios, M D, Green, T R, Tephly   +3 more
openaire   +2 more sources

Steroid UDP glucuronosyltransferases

The Journal of Steroid Biochemistry and Molecular Biology, 1992
The glucuronidation of steroids is a major process necessary for their elimination in the bile and urine. In general, steroid glucuronides are biologically less reactive than their parent steroids. However, in some cases often associated with disease and steroid therapy, more reactive or toxic glucuronides may be formed.
P I, Mackenzie, L, Rodbourne, S, Stranks
openaire   +2 more sources

Human UDP-Glucuronosyltransferase 2B7

Current Drug Metabolism, 2001
UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze the confugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GlcUA) as the sugar donor.
A, Radominska-Pandya, J M, Little, P J, Czernik   +2 more
openaire   +2 more sources

Heterodimerization of Human UDP-Glucuronosyltransferase 1A9 and UDP-Glucuronosyltransferase 2B7 Alters Their Glucuronidation Activities

Drug Metabolism and Disposition, 2023
Human UDP-glucuronosyltransferases (UGTs) play a pivotal role as prominent phase II metabolic enzymes, mediating the glucuronidation of both endobiotics and xenobiotics. Dimerization greatly modulates the enzymatic activities of UGTs. In this study, we examined the influence of three mutations (H35A, H268Y, and N68A/N315A) and four truncations (signal ...
Jia Xue, Jiayi Yin, Jing Nie, Huidi Jiang, Haitao Zhang, Su Zeng   +5 more
openaire   +2 more sources