Results 221 to 230 of about 57,370 (289)

Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1. [PDF]

PLoS One, 2019
Zhang B, Yang J, Qin Z, Li S, Xu J, Yao Z, Zhang X, Gonzalez FJ, Yao X.   +8 more
europepmc   +1 more source

Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation. [PDF]

Pharmaceutics, 2018
Shrestha R, Cho PJ, Paudel S, Shrestha A, Kang MJ, Jeong TC, Lee ES, Lee S.   +7 more
europepmc   +1 more source

TATA-box polymorphism in the urine diphosphate glucuronosyl transferase gene in Portuguese patients with clinical diagnosis of gilbert syndrome [PDF]

, 2002
Barbot, José, Costa, Elísio, Santos, Rosário, Santos-Silva, Ermelinda, Vieira, Emília   +4 more
core  

Drug-Metabolizing Gene Expression Identity: Comparison Across Liver Tissues and Model Cell Lines. [PDF]

Biomedicines
Arzumanian VA, Timofeeva EV, Kiseleva OI, Poverennaya EV.   +3 more
europepmc   +1 more source

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Transcriptional regulation of human UDP-glucuronosyltransferase genes

Drug Metabolism Reviews, 2014
Glucuronidation is an important metabolic pathway for many small endogenous and exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids, carcinogens and therapeutic drugs. Glucuronidation is primarily catalyzed by the UDP-glucuronosyltransferase (UGT) 1A and two subfamilies, including nine functional UGT1A enzymes (1A1, 1A3 ...
Dong Gui, Hu, Robyn, Meech, Ross A, McKinnon, Peter I, Mackenzie   +3 more
openaire   +3 more sources

UDP-Glucuronosyltransferases

Current Drug Metabolism, 2000
Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen ...
C D, King, G R, Rios, M D, Green, T R, Tephly   +3 more
openaire   +2 more sources

Steroid UDP glucuronosyltransferases

The Journal of Steroid Biochemistry and Molecular Biology, 1992
The glucuronidation of steroids is a major process necessary for their elimination in the bile and urine. In general, steroid glucuronides are biologically less reactive than their parent steroids. However, in some cases often associated with disease and steroid therapy, more reactive or toxic glucuronides may be formed.
P I, Mackenzie, L, Rodbourne, S, Stranks
openaire   +2 more sources

Characterization of the Ontogeny of Hepatic UDP‐Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes

Journal of clinical pharmacology, 2019
An understanding of the postnatal development of hepatic UDP‐glucuronosyltransferase (UGT) enzymes is required for accurate prediction of the age‐dependent changes in pharmacokinetics of many drugs used in children.
J. Badée, N. Qiu, A. Collier, Ryan H Takahashi, W. Forrest, N. Parrott, S. Schmidt, S. Fowler   +7 more
semanticscholar   +1 more source

Human UDP-Glucuronosyltransferase 2B7

Current Drug Metabolism, 2001
UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze the confugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GlcUA) as the sugar donor.
A, Radominska-Pandya, J M, Little, P J, Czernik   +2 more
openaire   +2 more sources