Results 241 to 250 of about 57,370 (289)

Monoclonal antibodies against 4-hydroxybiphenyl-UDP-glucuronosyltransferase

Biochemical Pharmacology, 1992
Monoclonal antibodies against purified rat liver 4-hydroxybiphenyl UDP-glucuronosyltransferase were developed using the hybridoma technology. In immunoblot analysis the antibodies specifically reacted with purified 4-hydroxybiphenyl-UDPGT but not with other purified UDPGT enzyme fractions.
C, Augustin, L, von Meyerinck, A, Schmoldt   +2 more
openaire   +2 more sources

UDP glucuronosyltransferase in the cirrhotic rat liver

Journal of Gastroenterology and Hepatology, 1996
AbstractIn patients with cirrhosis, the elimination of drugs metabolized by glucuronidation is relatively preserved, in comparison with the metabolism of drugs by oxidation. This study explores this phenomenon at a molecular level. In cirrhotic rat livers the content of UDP‐glucuronosyltransferase (UGT) was examined by immunohistochemistry and ...
H S, Debinski, P I, Mackenzie, C S, Lee, M L, Mashford, J A, Danks, T R, Tephly, M, Green, P V, Desmond   +7 more
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Isolation and purification of UDP-glucuronosyltransferases

Chemical Research in Toxicology, 1990
UDPGTs are members of a class of enzymes located in the endoplasmic reticulum and are encoded by a multigene family. These proteins are responsible for the glucuronidation of hundreds of xenobiotics of many chemical classes and many endogenous substances such as steroid hormones, bile acids, and bilirubin.
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Human UDP-Glucuronosyltransferases: Metabolism, Expression, and Disease

Annual Review of Pharmacology and Toxicology, 2000
In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the formation of water-soluble metabolites originating from normal dietary processes, cellular catabolism, or exposure to drugs and xenobiotics.
R H, Tukey, C P, Strassburg
openaire   +2 more sources

UDP-glucuronosyltransferases: a family of detoxifying enzymes

Trends in Pharmacological Sciences, 1990
Glucuronidation is an important process in the metabolism of xenobiotic and endogenous substances leading to enhancement of excretion of these compounds from the body. A multigene family encodes a number of UDP-glucuronosyltransferase enzymes which catalyse this route of metabolism.
T R, Tephly, B, Burchell
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Mouse UDP glucuronosyltransferase

European Journal of Biochemistry, 1987
A cDNA clone (UDPGTm‐1) encoding a mouse UDP glucuronosyltransferase (transferase) was isolated from pBR322 and λgt11 libraries by hybridization to a rat transferase clone. This cDNA is 1860 bp long and 65–87% similar at both the nucleotide and the deduced amino acid sequence levels to three different rat transferase clones [Mackenzie, P. I.
T, Kimura, I S, Owens
openaire   +2 more sources

Polymorphism of UDP-Glucuronosyltransferase and Drug Metabolism

Current Drug Metabolism, 2005
UDP-glucuronosyltransferase is a group of catabolic enzymes involved in the detoxification and excretion of many xenobiotic and endogeneous substances in intrahepatic and extrahepatic tissues. The group consists of two subfamilies, UGT1 and UGT2. UGT1 consists of 5 exons and has a unique gene structure.
Yoshihiro, Maruo, Masaru, Iwai, Asami, Mori, Hiroshi, Sato, Yoshihiro, Takeuchi   +4 more
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Natural and synthetic inhibitors of UDP-glucuronosyltransferase

Pharmacology & Therapeutics, 2001
Glucuronidation is a major detoxification pathway in vertebrates. The reaction is catalyzed by a family of UDP-glucuronosyltransferases (UGTs) and involves conjugation of many endobiotic and xenobiotic substances with glucuronic acid, forming inactive water-soluble glucuronides.
K, Grancharov, Z, Naydenova, S, Lozeva, E, Golovinsky   +3 more
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Transcriptional Regulation of UDP-Glucuronosyltransferases

2009
Totowa, New ...
Xie, Wen, Mackenzie, Peter Ian, Radominska-Pandya, A   +2 more
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Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2011
UDP glucuronosyltransferases (UGTs) are important for the metabolism of many drugs. To understand the ontogeny of these enzymes in sheep (Ovis aries), knowledge of their expression levels at different developmental stages is important. cDNA sequences of six UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) were cloned in sheep liver by rapid ...
Manoja, Pretheeban, Geoff, Hammond, Stelvio, Bandiera, Wayne, Riggs, Dan, Rurak   +4 more
openaire   +2 more sources