Results 81 to 90 of about 9,904 (211)

Expression of a high-affinity form of UDP-glucuronosyltransferase in human foetal liver cells in culture on exposure to mercuric chloride [PDF]

, 1991
Theresa May Chin Tan, Kim Ping Wong, K.H. Sit   +2 more
openalex   +1 more source

Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model. [PDF]

Drug Metab Dispos, 2022
Mennillo E, Yang X, Weber AA, Maruo Y, Verreault M, Barbier O, Chen S, Tukey RH.   +7 more
europepmc   +1 more source

Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver. [PDF]

Drug Metab Dispos, 2022
Sharma S, Ahire D, Basit A, Lajoie M, Wang C, Lee MS, Blithe DL, Amory JK, Singh DK, Heyward S, Prasad B.   +10 more
europepmc   +1 more source

Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1.

PLoS ONE, 2019
UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that is found in the endoplasmic reticulum membrane and can reportedly have a large number of amino acid substitutions that result in the reduction of glucuronidation capacity.
Yutaka Takaoka, Atsuko Takeuchi, Aki Sugano, Kenji Miura, Mika Ohta, Takashi Suzuki, Daisuke Kobayashi, Takuji Kimura, Juichi Sato, Nobutaro Ban, Hisahide Nishio, Toshiyuki Sakaeda   +11 more
doaj   +1 more source

Stereoselective Covalent Adduct Formation of Acyl Glucuronide Metabolite of Nonsteroidal Anti-Inflammatory Drugs with UDP-Glucuronosyltransferase. [PDF]

Int J Mol Sci, 2022
Kawase A, Yamashita R, Yoshizato T, Yoshikawa M, Shimada H, Iwaki M.   +5 more
europepmc   +1 more source

A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders[S]

Journal of Lipid Research, 2013
Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones.
Zhong-Ze Fang, Rong-Rong He, Yun-Feng Cao, Naoki Tanaka, Changtao Jiang, Kristopher W. Krausz, Yunpeng Qi, Pei-Pei Dong, Chun-Zhi Ai, Xiao-Yu Sun, Mo Hong, Guang-Bo Ge, Frank J. Gonzalez, Xiao-Chi Ma, Hong-Zhi Sun   +14 more
doaj  

Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1. [PDF]

Front Pharmacol, 2022
Pang HL, Zhu GH, Zhou QH, Ai CZ, Zhu YD, Wang P, Dou TY, Xia YL, Ma H, Ge GB.   +9 more
europepmc   +1 more source

Induction of Hepatic Microsomal UDP-Glucuronosyltransferase Activity in Nifedipine Treated Rats [PDF]

, 1990
Young Sook Hong, Young-Sook Pae
openalex   +1 more source

The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human Diseases. [PDF]

J Pers Med, 2021
Jarrar Y, Lee SJ.
europepmc   +1 more source

Gastrointestinal Cancers with Consideration of DPD and UGT1A1 Plasma Levels: Chemotherapy-Related Toxicity

Life
Unpredictable, dose-limiting toxicity remains a challenge in cancer treatment. We evaluated dihydropyrimidine dehydrogenase (DPD) and UDP-glucuronosyltransferase 1A1 (UGT1A1) plasma levels in the context of chemotherapy-induced toxicity and disease ...
Velko Minchev, Hristo Tsankov, Bozil Robev, Martin Takov, Stefan Federchev, Kalina Kamenova, Lozan Todorov, Liliya Atanasova, Nadya Hristova-Avakumova, Rumen Nikolov, Pavlina Gateva, Vanyo Mitev   +11 more
doaj   +1 more source