Results 81 to 90 of about 57,370 (289)
Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.Abstract SGR‐1505 is a novel small‐molecule inhibitor of MALT1, a key mediator of NF‐κB signaling implicated in the pathogenesis of B‐cell malignancies. This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of SGR‐1505 in healthy volunteers. In this four‐part, open‐label study, 73 participants received single or multiple
Vipul K. Gupta +16 more
wiley +1 more source
The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids [PDF]
, 2016 At a population level there is growing evidence for the beneficial effects of dietary flavonoids on health. However there is extensive heterogeneity in the response to increased intake, which is likely mediated via wide inter-individual variability in ...
Cassidy, Aedin, Minihane, Anne-Marie
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Journal of Lipid Research, 2013 Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones.
Zhong-Ze Fang +14 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 1, January 2026.Postbiotics are bioactive compounds derived from microbial fermentation, including short‐chain fatty acids, extracellular polysaccharides, and cell wall components. These molecules support health by regulating immune responses, enhancing gut barrier integrity, reducing inflammation, and modulating gut–brain and gut–liver communication.
Alice Njolke Mafe +4 more
wiley +1 more source
Weekly irinotecan in a patient with metastatic colorectal cancer on hemodialysis due to chronic renal failure [PDF]
, 2002 Background: The cytotoxic treatment of patients suffering from advanced or metastatic cancer undergoing hemodialysis due to chronic renal failure still remains a problem, since for those patients pharmacokinetic and pharmacodynamic data on most cytotoxic
Hacker, U. +4 more
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The clinical application of
Human Genomics, 2010 Over the past decade, the number of pharmacogenetic tests has increased considerably, allowing for the development of our knowledge of their clinical application.
Marques Sara, Ikediobi Ogechi N
doaj +1 more source
Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells [PDF]
, 2021 Takashi Kitaguchi +10 more
openalex +1 more source
Food Science &Nutrition, Volume 14, Issue 1, January 2026.Systematic bioactivity profiling revealed C. frutescens demonstrated significantly superior radical scavenging capacity (DPPH IC50: 111.96 ± 3.24 μg/mL; 2.5‐fold enhancement, p < 0.001), enhanced broad‐spectrum antibacterial efficacy (zone diameters: 8–22 mm), and notable cytotoxic activity meeting NCI preliminary criteria (LC50: 29.24 ± 1.15 μg/mL ...
Shahin Akter +4 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates +26 more
wiley +1 more source
Successful Pregnancy Outcome In Maternal Crigler Najjar Syndrome Type II. [PDF]
, 2012 Estimated incidence of Crigler-Najjar syndrome(CNS) is 1 case per 1,000,000 births(1 million). The overall prevalence of CN syndrome is unknown, with only several hundred people reported to have this disease.
Padmalatha, VV +3 more
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