Results 181 to 190 of about 60,978 (228)

Contribution of UDP-glycosyltransferases to chlorpyrifos resistance in Nilaparvata lugens

Pesticide Biochemistry and Physiology, 2023
As a multigene superfamily of Phase II detoxification enzymes, uridine diphosphate (UDP)-glycosyltransferases (UGTs) play important roles in the metabolism of xenobiotics including insecticides. In this study, 5-nitrouracil, an inhibitor of UGT enzyme activity, effectively increased the toxicity of chlorpyrifos to the chlorpyrifos-resistant strain of ...
Zhiming, Yang, Tianxiang, Xiao, Kai, Lu
openaire   +2 more sources

Identification and characterization of UDP-Glycosyltransferase genes and the potential role in response to insecticides exposure in Bactrocera dorsalis.

Pest Management Science, 2022
BACKGROUND The oriental fruit fly, Bactrocera dorsalis (Hendel) is a worldwide pest damaging a wide range of hosts. Due to the long-term indiscriminate use of insecticides, B. dorsalis has developed serious resistance to several insecticides.
Mengling Chen, Shu-Xia Zhang, P. Guo, Qing-Shi Qin, Li-Wei Meng, Guorui Yuan, Jinjun Wang   +6 more
semanticscholar   +1 more source

Triterpenoid-biosynthetic UDP-glycosyltransferases from plants

Biotechnology Advances, 2019
Triterpenoid saponins are naturally occurring structurally diverse glycosides of triterpenes that are widely distributed among plant species. Great interest has been expressed by pharmaceutical and agriculture industries for the glycosylation of triterpenes.
Shadi Rahimi, Jaewook Kim, Ivan Mijakovic, Ki-Hong Jung, Giltsu Choi, Sun-Chang Kim, Yu-Jin Kim   +6 more
openaire   +2 more sources

UGT3A: novel UDP-glycosyltransferases of the UGT superfamily

Drug Metabolism Reviews, 2009
Mammalian UDP-glycosyltransferases (UGTs) are divided into four families: UGT1, UGT2, UGT3, and UGT8. UGT3 is the last of the gene families to be identified, and until relatively recently, little was known about the function of these enzymes. In this article, we present new analyses of the UGT3 family genes, including the structure of the UGT3A locus ...
Mackenzie, Peter Ian, Meech, Robyn
openaire   +3 more sources

Overexpression of Multiple UDP-Glycosyltransferase Genes Involved in Sulfoxaflor Resistance in Aphis gossypii Glover.

Journal of Agricultural and Food Chemistry, 2021
UDP-glycosyltransferases (UGTs) are major phase II enzymes involved in the metabolic detoxification of xenobiotics. In this study, two UGT-inhibitors, 5-nitrouracil and sulfinpyrazone, significantly increased sulfoxaflor toxicity against sulfoxaflor ...
Li Wang, Junshu Zhu, Li Cui, Qinqin Wang, Weiling Huang, Qingjie Yang, Xuejiao Ji, Changhui Rui   +7 more
semanticscholar   +1 more source

UDP-glycosyltransferases contribute to spirotetramat resistance in Aphis gossypii Glover

Pesticide Biochemistry and Physiology, 2020
Uridine diphosphate (UDP)-glycosyltransferases (UGTs) catalyze the conjugation of small lipophilic endogenous and exogenous compounds with sugars to produce water-soluble glycosides, playing an important role in insect endobiotic regulation and xenobiotic detoxification. In this study, two UGT-inhibitors, sulfinpyrazone and 5-nitrouracil, significantly
Yiou, Pan, Shuyuan, Wen, Xuewei, Chen, Xiwu, Gao, Xiaochun, Zeng, Xuemei, Liu, Fayi, Tian, Qingli, Shang   +7 more
openaire   +2 more sources

Structural, Functional, and Mutagenesis Studies of UDP-Glycosyltransferases

2012
The biosynthesis of the complex carbohydrates that govern many cellular functions requires the action of a diverse range of selective glycosyltransferases (GTs). Uridine diphosphate sugar-utilizing GTs (UGTs) account for the majority of characterized GTs.
Vatsala, Malik, Gary W, Black
openaire   +2 more sources

Enzymatic biosynthesis of novel neobavaisoflavone glucosides via Bacillus UDP-glycosyltransferase

Chinese Journal of Natural Medicines, 2017
The present study was designed to perform structural modifications of of neobavaisoflavone (NBIF), using an in vitro enzymatic glycosylation reaction, in order to improve its water-solubility. Two novel glucosides of NBIF were obtained from an enzymatic glycosylation by UDP-glycosyltransferase. The glycosylated products were elucidated by LC-MS, HR-ESI-
Tao, Ma, Yi-Qun, Dai, Nan, Li, Qiang, Huo, Hong-Mei, Li, Yu-Xin, Zhang, Zheng-Hao, Piao, Cheng-Zhu, Wu   +7 more
openaire   +2 more sources

UDP-glycosyltransferases contribute to the tolerance of parasitoid wasps towards insecticides

Pesticide Biochemistry and Physiology, 2021
Meteorus pulchricornis (Wesmael) (Hymenoptera: Braconidae) is a predominant endoparasitoid of lepidopteran pests in mulberry fields. Extensive application of insecticides puts natural enemies under threat. UDP-glycosyltransferases (UGTs), as important detoxification enzymes, potentially contribute to the detoxification of pesticides in insects.
Meng-Wen, Yan, Xiao-Rong, Xing, Fu-An, Wu, Jun, Wang, Sheng, Sheng   +4 more
openaire   +2 more sources

Directed Evolution of the UDP-Glycosyltransferase UGTBL1 for Highly Regioselective and Efficient Biosynthesis of Natural Phenolic Glycosides.

Journal of Agricultural and Food Chemistry
The O-glycosylation of polyphenols for the synthesis of glycosides has garnered substantial attention in food research applications. However, the practical utility of UDP-glycosyltransferases (UGTs) is significantly hindered by their low catalytic ...
Chenhao Zhang, Yongchao Cai, Zehua Zhang, Nan Zheng, Huimin Zhou, Yumeng Su, Shuang Du, Asif Hussain, Xiaole Xia   +8 more
semanticscholar   +1 more source