Results 161 to 170 of about 68,086 (202)

Overexpression of Multiple UDP-Glycosyltransferase Genes Involved in Sulfoxaflor Resistance in Aphis gossypii Glover.

Journal of Agricultural and Food Chemistry, 2021
UDP-glycosyltransferases (UGTs) are major phase II enzymes involved in the metabolic detoxification of xenobiotics. In this study, two UGT-inhibitors, 5-nitrouracil and sulfinpyrazone, significantly increased sulfoxaflor toxicity against sulfoxaflor ...
Li Wang, Junshu Zhu, Li Cui, Qinqin Wang, Weiling Huang, Qingjie Yang, Xuejiao Ji, Changhui Rui   +7 more
semanticscholar   +1 more source

Directed Evolution of the UDP-Glycosyltransferase UGTBL1 for Highly Regioselective and Efficient Biosynthesis of Natural Phenolic Glycosides.

Journal of Agricultural and Food Chemistry
The O-glycosylation of polyphenols for the synthesis of glycosides has garnered substantial attention in food research applications. However, the practical utility of UDP-glycosyltransferases (UGTs) is significantly hindered by their low catalytic ...
Chenhao Zhang, Yongchao Cai, Zehua Zhang, Nan Zheng, Huimin Zhou, Yumeng Su, Shuang Du, Asif Hussain, Xiaole Xia   +8 more
semanticscholar   +1 more source

Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.

Pharmacogenetics and Genomics, 2005
Several novel UDP glycosyltransferase (UGT) genes, mainly UDP glucuronosyltransferases, have been identified in the human, mouse and rat genomes and in other mammalian species. This review provides an update of the UGT nomenclature to include these new genes and prevent the confusion that arises when the same gene is given different names.
P. Mackenzie, K. Bock, B. Burchell, C. Guillemette, S. Ikushiro, T. Iyanagi, J. Miners, I. Owens, D. Nebert   +8 more
semanticscholar   +3 more sources

Progress in Identification of UDP-Glycosyltransferases for Ginsenoside Biosynthesis

Journal of Natural Products
Ginsenosides, the primary pharmacologically active constituents of the Panax genus, have demonstrated a variety of medicinal properties, including anticardiovascular disease, cytotoxic, antiaging, and antidiabetes effects. However, the low concentration of ginsenosides in plants and the challenges associated with their extraction impede the advancement
Xiaoxuan Yuan, Ruiqiong Li, Weishen He, Wei Xu, Wen Xu, Guohong Yan, Shaohua Xu, Lixia Chen, Yaqian Feng, Hua Li   +9 more
openaire   +2 more sources

A UDP-glycosyltransferase gene PcUGT202A9 was associated with abamectin resistance in Panonychus citri (McGregor).

International Journal of Biological Macromolecules
Panonychus citri (McGregor) strains have developed a high level of resistance to abamectin, but the underlying molecular mechanism is unknown. Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are critical for the removal of a variety of exogenous ...
Binbin Shao, Shi-Jiang Yu, Shuqi Wang, Sichen Li, Lili Ding, Ming-Yue Li, Lu-Yan Cheng, Qi Pan, Lin Cong, C. Ran   +9 more
semanticscholar   +1 more source

The Role of UDP-Glycosyltransferases in Xenobiotic Metabolism

Journal of Evolutionary Biochemistry and Physiology
UDP-glycosyltransferases (UGTs) are enzymes from a complex superfamily of glycosyltransferases. UGTs catalyze glycosylation reactions, i.e. the covalent addition of sugar from a cofactor (UDP-glycoside) to the corresponding functional group of a lipophilic substrate. These enzymes play a crucial role in cellular homeostasis of many groups of organisms (
A. G. Kinareykina, E. A. Silivanova
openaire   +1 more source

Perinatal Development of Bilirubin UDP-Glycosyltransferase Activities in Rat Liver

Biology of the Neonate, 2009
Bilirubin UDP-glucuronyltransferase and UDP-xylosyltransferase activity could already be demonstrated in rat liver from day 19 of fetal life onwards (4 days before birth). Bilirubin-glucuronide was present in hepatocytes of 21-day-old fetal liver strongly suggesting that the enzyme detected in vitro was really active in vivo.
J, Fevery, C, De Wolf-Peeters, R, De Vos, V, Desmet, K P, Heirwegh   +4 more
openaire   +2 more sources

UDP-glycosyltransferases contribute to spirotetramat resistance in Aphis gossypii Glover

Pesticide Biochemistry and Physiology, 2020
Uridine diphosphate (UDP)-glycosyltransferases (UGTs) catalyze the conjugation of small lipophilic endogenous and exogenous compounds with sugars to produce water-soluble glycosides, playing an important role in insect endobiotic regulation and xenobiotic detoxification. In this study, two UGT-inhibitors, sulfinpyrazone and 5-nitrouracil, significantly
Yiou, Pan, Shuyuan, Wen, Xuewei, Chen, Xiwu, Gao, Xiaochun, Zeng, Xuemei, Liu, Fayi, Tian, Qingli, Shang   +7 more
openaire   +2 more sources

Contribution of UDP-glycosyltransferases to clothianidin resistance in Bradysia odoriphaga

Pesticide Biochemistry and Physiology
Uridine diphosphate glycosyltransferases (UGTs) play critical roles in xenobiotic detoxification and are involved in insecticide resistance. In this study, UGT inhibitors, sulfinpyrazone and 5-nitrouracil, exhibited significant synergistic effects on clothianidin in the clothianidin-resistant strain (CL-R) of Bradysia odoriphaga. UGT enzyme content was
Chunni, Zhang, Ruifang, Liu, Xianglong, Chen, Xianling, Du, Shiying, Tang, Wu, Dai   +5 more
openaire   +2 more sources

A novel UDP-glycosyltransferase 91C1 confers specific herbicide resistance through detoxification reaction in Arabidopsis.

Plant physiology and biochemistry : PPB, 2020
Plants can reduce or eliminate the damage caused by herbicides and gain herbicide resistance, which is an important theoretical basis for the development of herbicide-resistant crops at this stage.
Xu-xu Huang, Shu-man Zhao, Yu-ying Zhang, Yan-jie Li, Han-nuo Shen, Xugang Li, Bing-kai Hou   +6 more
semanticscholar   +1 more source