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Insect UDP-glycosyltransferases and xenobiotic metabolism

Pesticide Biochemistry and Physiology
UDP-glycosyltransferases (UGTs) are a superfamily of enzymes ubiquitously found in virtually all organisms. They catalyze the addition of sugars from UDP-sugar donors that greatly enhance the water solubility of molecules, facilitating excretion. There are 10-76 Ugts in different insect species, and the last decade has seen a remarkable increase in ...
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Enzymatic synthesis of novel isobavachalcone glucosides via a UDP-glycosyltransferase

Archives of Pharmacal Research, 2015
Glycosylation is often used to improve a natural product's properties such as water solubility, chemical stability, pharmacological potency, and structure diversification. In this study, we studied the enzymatic synthesis of novel isobavachalcone glucosides using a UDP-glycosyltransferase (YjiC) from Bacillus licheniformis DSM-13.
Hong-Mei, Li   +7 more
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Drosophila Cellular Immune System: Dorothy Encodes a UDP Glycosyltransferase

2001
Immune defense in Drosophila has humoral and cellular components that act effectively to control infectious organisms through the production of antimicrobial proteins and the phagocytosis and encapsulation of invading organisms (reviewed in 9). The main tissue of humoral immune defense is the fat body, which corresponds to the mammalian liver. Cellular
Z, Zhou   +3 more
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Enzymatic synthesis of novel corylifol A glucosides via a UDP-glycosyltransferase

Carbohydrate Research, 2017
Corylifol A, a member of the isoflavone subclass of isoflavonoids, has long been considered to have various biological activities. Here, we sought to synthesize corylifol A glucosides by the in vitro glucosylation reaction using the UDP-glycosyltransferase YjiC from Bacillus licheniformis DSM 13, and obtained two novel glucosides: corylifol A-4',7-di-O-
Nan Li   +8 more
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Metabolic detoxification of capsaicin by UDP‐glycosyltransferase in three Helicoverpa species

Archives of Insect Biochemistry and Physiology, 2011
AbstractCapsaicin β‐glucoside was isolated from the feces of Helicoverpa armigera, Helicoverpa assulta, and Helicoverpa zea that fed on capsaicin‐supplemented artificial diet. The chemical structure was identified by NMR spectroscopic analysis as well as by enzymatic hydrolysis.
Ahn, S.   +6 more
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Enzymatic Synthesis of Novel Bavachinin Glucoside by UDP‐glycosyltransferase

Journal of the Chinese Chemical Society, 2016
AbstractBavachinin, a member of the flavanone subclass of flavonoids, has long been considered to have various biological activities. Here, the synthesis of novel bavachinin glucoside by the in vitro glycosylation reaction was successfully achieved using a UDP‐glucosyltransferase YjiC, from Bacillus licheniformis DSM‐13.
Yiqun Dai   +8 more
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Overexpression of UDP-glycosyltransferase potentially involved in insecticide resistance in Aphis gossypii Glover collected from Bt cotton fields in China.

Pest Management Science, 2019
BACKGROUN The cotton aphid, Aphis gossypii Glover is one of the most destructive insect pests. It has evolved resistance to numerous insecticides around the world due to the application of insecticides.
Xuewei Chen   +5 more
semanticscholar   +1 more source

The glycosidation of xenobiotics and endogenous compounds: Versatility and redundancy in the UDP glycosyltransferase superfamily

Pharmacology & Therapeutics, 2012
The covalent addition of sugars to small organic molecules is mediated by a superfamily of UDP glycosyltransferases (UGTs) found in animals, plants and bacteria. This superfamily evolved by gene duplication and divergence to manage exposure to a changing environment of lipophilic chemicals.
Robyn, Meech   +3 more
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Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3

ACS Catalysis, 2023
Wei Huang   +10 more
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UDP-glycosyltransferase gene SlUGT73C1 from Solanum lycopersicum regulates salt and drought tolerance in Arabidopsis thaliana L.

Functional & Integrative Genomics, 2023
Mengdi Lu   +8 more
semanticscholar   +1 more source

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