Results 171 to 180 of about 44,652 (214)
The Novel UDP Glycosyltransferase 3A2: Cloning, Catalytic Properties, and Tissue Distribution
Molecular Pharmacology, 2011 The human UDP glycosyltransferase (UGT) 3A family is one of three families involved in the metabolism of small lipophilic compounds. Members of these families catalyze the addition of sugar residues to chemicals, which enhances their excretion from the ...
John Miners, Peter I Mackenzie, Nuy Chau
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Contribution of UDP-glycosyltransferases to chlorpyrifos resistance in Nilaparvata lugens
Pesticide Biochemistry and Physiology, 2023As a multigene superfamily of Phase II detoxification enzymes, uridine diphosphate (UDP)-glycosyltransferases (UGTs) play important roles in the metabolism of xenobiotics including insecticides. In this study, 5-nitrouracil, an inhibitor of UGT enzyme activity, effectively increased the toxicity of chlorpyrifos to the chlorpyrifos-resistant strain of ...
Zhiming, Yang, Tianxiang, Xiao, Kai, Lu
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Triterpenoid-biosynthetic UDP-glycosyltransferases from plants
Biotechnology Advances, 2019Triterpenoid saponins are naturally occurring structurally diverse glycosides of triterpenes that are widely distributed among plant species. Great interest has been expressed by pharmaceutical and agriculture industries for the glycosylation of triterpenes.
Shadi Rahimi +6 more
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UGT3A: novel UDP-glycosyltransferases of the UGT superfamily
Drug Metabolism Reviews, 2009Mammalian UDP-glycosyltransferases (UGTs) are divided into four families: UGT1, UGT2, UGT3, and UGT8. UGT3 is the last of the gene families to be identified, and until relatively recently, little was known about the function of these enzymes. In this article, we present new analyses of the UGT3 family genes, including the structure of the UGT3A locus ...
Mackenzie, Peter Ian, Meech, Robyn
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Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs
Drug Metabolism Reviews, 2022The human UGT gene superfamily is divided into four subfamilies (UGT1, UGT2, UGT3 and UGT8) that encodes 22 functional enzymes. UGTs are critical for the metabolism and clearance of numerous endogenous and exogenous compounds, including steroid hormones, bile acids, bilirubin, fatty acids, carcinogens, and therapeutic drugs.
Dong Gui, Hu +4 more
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A Novel Function for UDP Glycosyltransferase 8: Galactosidation of Bile Acids
Molecular Pharmacology, 2015The human UDP glycosyltransferase (UGT) superfamily comprises four families of enzymes that catalyze the addition of sugar residues to small lipophilic chemicals. The UGT1 and UGT2 enzymes use UDP-glucuronic acid, and UGT3 enzymes use UDP-N-acetylglucosamine, UDP-glucose, and UDP-xylose to conjugate xenobiotics, including drugs and endobiotics such as ...
Peter I Mackenzie +2 more
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Structural, Functional, and Mutagenesis Studies of UDP-Glycosyltransferases
2012The biosynthesis of the complex carbohydrates that govern many cellular functions requires the action of a diverse range of selective glycosyltransferases (GTs). Uridine diphosphate sugar-utilizing GTs (UGTs) account for the majority of characterized GTs.
Vatsala, Malik, Gary W, Black
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UDP-glycosyltransferases contribute to the tolerance of parasitoid wasps towards insecticides
Pesticide Biochemistry and Physiology, 2021Meteorus pulchricornis (Wesmael) (Hymenoptera: Braconidae) is a predominant endoparasitoid of lepidopteran pests in mulberry fields. Extensive application of insecticides puts natural enemies under threat. UDP-glycosyltransferases (UGTs), as important detoxification enzymes, potentially contribute to the detoxification of pesticides in insects.
Meng-Wen, Yan +4 more
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Progress in Identification of UDP-Glycosyltransferases for Ginsenoside Biosynthesis
Journal of Natural ProductsGinsenosides, the primary pharmacologically active constituents of the Panax genus, have demonstrated a variety of medicinal properties, including anticardiovascular disease, cytotoxic, antiaging, and antidiabetes effects. However, the low concentration of ginsenosides in plants and the challenges associated with their extraction impede the advancement
Xiaoxuan Yuan +9 more
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The Role of UDP-Glycosyltransferases in Xenobiotic Metabolism
Journal of Evolutionary Biochemistry and PhysiologyUDP-glycosyltransferases (UGTs) are enzymes from a complex superfamily of glycosyltransferases. UGTs catalyze glycosylation reactions, i.e. the covalent addition of sugar from a cofactor (UDP-glycoside) to the corresponding functional group of a lipophilic substrate. These enzymes play a crucial role in cellular homeostasis of many groups of organisms (
A. G. Kinareykina, E. A. Silivanova
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