Results 191 to 200 of about 60,978 (228)

Medicinal terpenoid UDP-glycosyltransferases in plants: recent advances and research strategies

Journal of Experimental Botany, 2022
AbstractTerpenoid glycosides have significant curative effects on many kinds of diseases. Most of these compounds are derived from medicinal plants. Glycosylation is a key step in the biosynthesis of medicinal terpenoids. In plants, UDP-dependent glycosyltransferases comprise a large family of enzymes that catalyze the transfer of sugars from donor to ...
Xu Lu, Lijin Huang, Henrik V Scheller, Jay D Keasling   +3 more
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Perinatal Development of Bilirubin UDP-Glycosyltransferase Activities in Rat Liver

Neonatology, 1977
Bilirubin UDP-glucuronyltransferase and UDP-xylosyltransferase activity could already be demonstrated in rat liver from day 19 of fetal life onwards (4 days before birth). Bilirubin-glucuronide was present in hepatocytes of 21-day-old fetal liver strongly suggesting that the enzyme detected <i>in vitro</i> was really active <i>in vivo&
J, Fevery, C, De Wolf-Peeters, R, De Vos, V, Desmet, K P, Heirwegh   +4 more
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Knocking Out of UDP-Glycosyltransferase Gene UGT2B10 via CRISPR/Cas9 in Helicoverpa armigera Reveals Its Function in Detoxification of Insecticides.

Journal of Agricultural and Food Chemistry
The role of insect UDP-glycosyltransferases (UGTs) in the detoxification of insecticides has rarely been reported. A UGT gene UGT2B10 was previously found overexpressed in a fenvalerate-resistant strain of Helicoverpa armigera. Herein, UGT2B10 was cloned,
Junyue Zheng, Xiangguang Chen, Yao Xie, Y. Zhang, Yun Huang, Peizhuo Wu, Jingshu Lv, Lihong Qiu   +7 more
semanticscholar   +1 more source

Drosophila Cellular Immune System: Dorothy Encodes a UDP Glycosyltransferase

2001
Immune defense in Drosophila has humoral and cellular components that act effectively to control infectious organisms through the production of antimicrobial proteins and the phagocytosis and encapsulation of invading organisms (reviewed in 9). The main tissue of humoral immune defense is the fat body, which corresponds to the mammalian liver. Cellular
Z, Zhou, A, Rodriguez, C Y, Wu, D A, Kimbrell   +3 more
openaire   +2 more sources

Enzymatic synthesis of novel isobavachalcone glucosides via a UDP-glycosyltransferase

Archives of Pharmacal Research, 2015
Glycosylation is often used to improve a natural product's properties such as water solubility, chemical stability, pharmacological potency, and structure diversification. In this study, we studied the enzymatic synthesis of novel isobavachalcone glucosides using a UDP-glycosyltransferase (YjiC) from Bacillus licheniformis DSM-13.
Hong-Mei, Li, Jae Kyoung, Lee, Li-Juan, Nie, Qiang, Huo, Tao, Ma, Jae Kyung, Sohng, Young-Soo, Hong, Cheng-Zhu, Wu   +7 more
openaire   +2 more sources

Characterization of human liver microsomal UDP-glycosyltransferases using photoaffinity analogs.

The Journal of Pharmacology and Experimental Therapeutics, 1995
The photoaffinity analogs [beta-32P]5-azido-UDP-glucuronic acid ([32P]5N3UDP-GlcUA) and [beta-32P]5-azido-UDP-glucose ([32P]5N3UDP-Glc) were used to characterize UDP-glycosyltransferases of microsomes prepared from human liver. Photoincorporation of both probes into proteins in the 50- to 56-kdalton range, known to contain UDP-glucuronosyl transferases
LITTLE, JM, DRAKE, RR, VONK, R, KUIPERS, F, LESTER, R, RADOMINSKA, A   +5 more
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Comparative analysis of the UDP-glycosyltransferase multigene family in insects

Insect Biochemistry and Molecular Biology, 2012
UDP-glycosyltransferases (UGT) catalyze the conjugation of a range of diverse small lipophilic compounds with sugars to produce glycosides, playing an important role in the detoxification of xenobiotics and in the regulation of endobiotics in insects.
Ahn, S., Vogel, H., Heckel, D.
openaire   +3 more sources

Progress in Identification of UDP-Glycosyltransferases for Ginsenoside Biosynthesis

Journal of Natural Products
Ginsenosides, the primary pharmacologically active constituents of the Panax genus, have demonstrated a variety of medicinal properties, including anticardiovascular disease, cytotoxic, antiaging, and antidiabetes effects. However, the low concentration of ginsenosides in plants and the challenges associated with their extraction impede the advancement
Xiaoxuan Yuan, Ruiqiong Li, Weishen He, Wei Xu, Wen Xu, Guohong Yan, Shaohua Xu, Lixia Chen, Yaqian Feng, Hua Li   +9 more
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The Role of UDP-Glycosyltransferases in Xenobiotic Metabolism

Journal of Evolutionary Biochemistry and Physiology
UDP-glycosyltransferases (UGTs) are enzymes from a complex superfamily of glycosyltransferases. UGTs catalyze glycosylation reactions, i.e. the covalent addition of sugar from a cofactor (UDP-glycoside) to the corresponding functional group of a lipophilic substrate. These enzymes play a crucial role in cellular homeostasis of many groups of organisms (
A. G. Kinareykina, E. A. Silivanova
openaire   +1 more source

Enzymatic Synthesis of Novel Bavachinin Glucoside by UDP‐glycosyltransferase

Journal of the Chinese Chemical Society, 2016
AbstractBavachinin, a member of the flavanone subclass of flavonoids, has long been considered to have various biological activities. Here, the synthesis of novel bavachinin glucoside by the in vitro glycosylation reaction was successfully achieved using a UDP‐glucosyltransferase YjiC, from Bacillus licheniformis DSM‐13.
Yiqun Dai, Tao Ma, Min Ge, Jing Li, Qiang Huo, Hong‐Mei Li, Xinyu Zhang, Hao Liu, Cheng‐Zhu Wu   +8 more
openaire   +1 more source