Results 41 to 50 of about 44,652 (214)

Qualitative and Quantitative NAD+ Metabolomics Lead to Discovery of Multiple Functional Nicotinate N-Glycosyltransferase in Arabidopsis

Frontiers in Plant Science, 2019
The Preiss-Handler pathway, which salvages nicotinate (NA) for NAD synthesis, is a conserved biochemical pathway in land plants. We previously demonstrated that various NA conjugations (mainly methylation and glycosylation) shared the NA detoxification ...
Lingyun Liu, Lingyun Liu, Fengxia Zhang, Guosheng Li, Guosheng Li, Guodong Wang, Guodong Wang   +6 more
doaj   +1 more source

Identification of UDP Glycosyltransferase 3A1 as a UDP N-Acetylglucosaminyltransferase [PDF]

Journal of Biological Chemistry, 2008
The UDP glycosyltransferases (UGT) attach sugar residues to small lipophilic chemicals to alter their biological properties and enhance elimination. Of the four families present in mammals, two families, UGT1 and UGT2, use UDP glucuronic acid to glucuronidate bilirubin, steroids, bile acids, drugs, and many other endogenous chemicals and xenobiotics ...
Mackenzie, Peter Ian, Rogers, Anne, Jorgensen, Bo R, Miners, John Oliver, Meech, Robyn, Gillis, Joanna Lee   +5 more
openaire   +3 more sources

Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls [PDF]

, 2007
Arabidopsis cell walls contain large amounts of pectins and hemicelluloses, which are predominantly synthesized via the common precursor UDP-glucuronic acid.
Tenhaken, Raimund, Klinghammer, Michaela
core   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

UDP-Glycosyltransferases and Albendazole Metabolism in the Juvenile Stages of Haemonchus contortus [PDF]

Frontiers in Physiology, 2020
The nematode Haemonchus contortus, a gastrointestinal parasite of ruminants, can severely burden livestock production. Although anthelmintics are the mainstay in the treatment of haemonchosis, their efficacy diminishes due to drug-resistance development in H. contortus.
Pavlína Kellerová, Martina Navrátilová, Linh Thuy Nguyen, Diana Dimunová, Lucie Raisová Stuchlíková, Karolína Štěrbová, Lenka Skálová, Petra Matoušková   +7 more
openaire   +3 more sources

Functional analysis of the Lactococcus lactis galU and galE genes and their impact on sugar nucleotide and exopolysaccharide biosynthesis [PDF]

, 2001
We studied the UDP-glucose pyrophosphorylase (galU) and UDP-galactose epimerase (galE) genes of Lactococcus lactis MG1363 to investigate their involvement in biosynthesis of UDP-glucose and UDP-galactose, which are precursors of glucose- and galactose ...
Boels, I.C., Vos, W.M., de, Kleerebezem, M., Ramos, A., de Vos, W.M.   +4 more
core   +1 more source

Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin. [PDF]

Plant J, 2019
Glycyrrhizin, a sweet triterpenoid saponin found in the roots and stolons of Glycyrrhiza species (licorice), is an important active ingredient in traditional herbal medicine.
Nomura Y, Seki H, Suzuki T, Ohyama K, Mizutani M, Kaku T, Tamura K, Ono E, Horikawa M, Sudo H, Hayashi H, Saito K, Muranaka T.   +12 more
europepmc   +2 more sources

Control of sexuality by the sk1-encoded UDP-glycosyltransferase of maize. [PDF]

Sci Adv, 2016
The maize silkless 1 gene encodes a UDP-glycosyltransferase that protects pistils from elimination by jasmonic acid signaling.
Hayward AP, Moreno MA, Howard TP, Hague J, Nelson K, Heffelfinger C, Romero S, Kausch AP, Glauser G, Acosta IF, Mottinger JP, Dellaporta SL.   +11 more
europepmc   +7 more sources

Ethanol triggers grape gene expression leading to anthocyanin accumulation during berry ripening [PDF]

, 2002
Recent studies have shown that low doses of ethanol stimulate the maturation of some fruits. The present work showed that spraying Cabernet Sauvignon grapes, with 5% ethanol at veraison enhances the anthocyanin accumulation.
Chervin, Christian, Ashraf El Kereamy, Nepveu, Françoise, Moutounet, Michel, Nepveu, F., Christian Chervin, Chervin, C., Jean-Marc Souquet, Michel Moutounet, Monje, Marie-Carmen, Ford, Christopher, Roustan, Jean-Paul, Christopher M Ford, Helene Mondies, Mondies, H., Souquet, J., Mondies, Hélène, Roustan, J., Jean-Paul Roustan, Ford, C., Ford, Christopher M, van Heeswijck, Robyn, El-Kereamy, Ashraf, Van Heeswijck, R., Françoise Nepveu, Robyn van Heeswijck, Marie-Carmen Monje, Monje, M., El-Kereamy, A., Souquet, Jean-Marc, Moutounet, M.   +30 more
core   +1 more source

Utility of Bioluminescent Homogeneous Nucleotide Detection Assays in Measuring Activities of Nucleotide-Sugar Dependent Glycosyltransferases and Studying Their Inhibitors

Molecules, 2021
Traditional glycosyltransferase (GT) activity assays are not easily configured for rapid detection nor for high throughput screening because they rely on radioactive product isolation, the use of heterogeneous immunoassays or mass spectrometry.
Laurie Engel, Juliano Alves, Jacquelyn Hennek, Said A. Goueli, Hicham Zegzouti   +4 more
doaj   +1 more source