Results 21 to 30 of about 13,141 (192)

A willow UDP-glycosyltransferase involved in salicinoid biosynthesis

Journal of Experimental Botany, 2020
Abstract The salicinoids are phenolic glycosides that are characteristic secondary metabolites of the Salicaceae, particularly willows and poplars. Despite the well-known pharmacology of salicin, that led to the development of aspirin >100 years ago, the biosynthetic pathways leading to salicinoids have yet to be defined. Here, we
Satish Kulasekaran, Sergio Cerezo-Medina, Claudia Harflett, Charlotte Lomax, Femke de Jong, Amelie Rendour, Gianluca Ruvo, Steven J Hanley, Michael H Beale, Jane L Ward   +9 more
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New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth

Frontiers in Chemistry, 2021
O-GlcNAcylation is an important post-translational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins ...
Matjaž Weiss, Elena M. Loi, Elena M. Loi, Maša Sterle, Cyril Balsollier, Cyril Balsollier, Tihomir Tomašič, Roland J. Pieters, Martina Gobec, Marko Anderluh   +9 more
doaj   +1 more source

Identification of UDP Glycosyltransferase 3A1 as a UDP N-Acetylglucosaminyltransferase [PDF]

Journal of Biological Chemistry, 2008
The UDP glycosyltransferases (UGT) attach sugar residues to small lipophilic chemicals to alter their biological properties and enhance elimination. Of the four families present in mammals, two families, UGT1 and UGT2, use UDP glucuronic acid to glucuronidate bilirubin, steroids, bile acids, drugs, and many other endogenous chemicals and xenobiotics ...
Mackenzie, Peter Ian, Rogers, Anne, Jorgensen, Bo R, Miners, John Oliver, Meech, Robyn, Gillis, Joanna Lee   +5 more
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In Porphyromonas gingivalis VimF is involved in gingipain maturation through the transfer of galactose. [PDF]

PLoS ONE, 2013
Previously, we have reported that gingipain activity in Porphyromonas gingivalis, the major causative agent in adult periodontitis, is post-translationally regulated by the unique Vim proteins including VimF, a putative glycosyltransferase.
Arun S Muthiah, Wilson Aruni, Antonette G Robles, Yuetan Dou, Francis Roy, Hansel M Fletcher   +5 more
doaj   +1 more source

Metabolic Engineering of Escherichia coli for Hyperoside Biosynthesis

Microorganisms, 2022
Hyperoside (quercetin 3-O-galactoside) exhibits many biological functions, along with higher bioactivities than quercetin. In this study, three UDP-dependent glycosyltransferases (UGTs) were screened for efficient hyperoside synthesis from quercetin. The
Guosi Li, Fucheng Zhu, Peipei Wei, Hailong Xue, Naidong Chen, Baowei Lu, Hui Deng, Cunwu Chen, Xinjian Yin   +8 more
doaj   +1 more source

Structural Basis for the Action Mechanism of Legionella Glycosyltransferase

Small Structures, 2023
Pathogenic bacterium Legionella pneumophila, the causative agent of Legionnaires’ disease, secretes hundreds of effectors into host cells that subvert cell pathways during pathogenesis.
Tao-Tao Chen, Si-Ru Zheng, Li Tian, Sunliang Lv, Wenhong Zhong, Xiangliang Li, Dandan Zhang, Xuexing Zheng, Songying Ouyang   +8 more
doaj   +1 more source

Identification of UGT85A glycosyltransferases associated with volatile conjugation in grapevine (Vitis vinifera × Vitis labrusca)

Horticultural Plant Journal, 2023
Glycosylated volatiles are considered as hidden aroma precursors that affect fruit flavor and are involved in plant defense response. Several uridine-diphosphate (UDP)-glycosyltransferase (UGT) members related to the glycosylation of volatiles have been ...
Xiangmei Cao, Dan Jiang, Hanqing Wang, Boping Wu, Jianhui Cheng, Bo Zhang   +5 more
doaj   +1 more source

Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol

Nature Communications, 2020
Biosynthesis of glycosylphosphatidylinositol (GPI) is essential for the integrity of the fungal cell wall. Here, the authors show that the natural product jawsamycin inhibits GPI biosynthesis by targeting a subunit of the fungal UDP-glycosyltransferase ...
Yue Fu, David Estoppey, Silvio Roggo, Dominik Pistorius, Florian Fuchs, Christian Studer, Ashraf S. Ibrahim, Thomas Aust, Frederic Grandjean, Manuel Mihalic, Klaus Memmert, Vivian Prindle, Etienne Richard, Ralph Riedl, Sven Schuierer, Eric Weber, Jürg Hunziker, Frank Petersen, Jianshi Tao, Dominic Hoepfner   +19 more
doaj   +1 more source

Qualitative and Quantitative NAD+ Metabolomics Lead to Discovery of Multiple Functional Nicotinate N-Glycosyltransferase in Arabidopsis

Frontiers in Plant Science, 2019
The Preiss-Handler pathway, which salvages nicotinate (NA) for NAD synthesis, is a conserved biochemical pathway in land plants. We previously demonstrated that various NA conjugations (mainly methylation and glycosylation) shared the NA detoxification ...
Lingyun Liu, Lingyun Liu, Fengxia Zhang, Guosheng Li, Guosheng Li, Guodong Wang, Guodong Wang   +6 more
doaj   +1 more source

UDP-Glycosyltransferases and Albendazole Metabolism in the Juvenile Stages of Haemonchus contortus [PDF]

Frontiers in Physiology, 2020
The nematode Haemonchus contortus, a gastrointestinal parasite of ruminants, can severely burden livestock production. Although anthelmintics are the mainstay in the treatment of haemonchosis, their efficacy diminishes due to drug-resistance development in H. contortus.
Pavlína Kellerová, Martina Navrátilová, Linh Thuy Nguyen, Diana Dimunová, Lucie Raisová Stuchlíková, Karolína Štěrbová, Lenka Skálová, Petra Matoušková   +7 more
openaire   +3 more sources