Results 11 to 20 of about 349 (70)

NMR-Based Structural Analysis of Highly Substituted Pyridines From Kondrat'eva Aza-Diels-Alder Cycloadditions. [PDF]

Magn Reson Chem
We report the results from a kinetic and mechanistic investigation of an inverse‐electron‐demand Diels–Alder (IEDDA) cycloaddition involving an oxazole‐type diene synthesized via an Ugi–Zhu multicomponent reaction (UZ‐3CR). ABSTRACT Pyridines are a crucial class of heterocycles with widespread applications in natural products, pharmaceuticals, and ...
Suárez-Moreno GV, Méndez F, Gutierrez-Carrillo A, Rincón-Guevara MA, Amador-Sánchez YA, Islas-Jácome A, González-Zamora E.   +6 more
europepmc   +2 more sources

Development of cytosine and adenine base editors for maize precision breeding. [PDF]

J Integr Plant Biol
A series of maize cytosine and adenine base editors was developed using various deaminase variants, enabling efficient multiplex genome editing in maize. Precise editing of the ZmACC1/2 genes generated herbicide‐tolerant maize germplasm, offering a solution for weed management in maize‐soybean intercropping systems.
Fu X, Wang N, Li L, Qiao D, Qi X, Liu C, Gao Z, Xie C, Zhu J.   +8 more
europepmc   +2 more sources

One-Pot Morita-Baylis-Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ-Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation. [PDF]

ChemSusChem
Sustainable one‐pot synthesis of functionalized γ‐hydroxy derivatives in deep eutectic solvents. A green, sequential CC/CX bond‐forming strategy enables diverse γ‐hydroxy derivatives via Morita–Baylis–Hillman and nucleophilic functionalization in ChCl/Gly deep eutectic solvent.
Ramos-Martín M, Del Río I, García-Álvarez J, Presa Soto A.   +3 more
europepmc   +2 more sources

Recent Contributions of Organic Synthesis to Forensic Science. [PDF]

Chempluschem
Forensic science is a multidisciplinary field that plays a vital role in providing scientific evidence for criminal investigations. This review highlights advances and opportunities at the interface between organic synthesis and forensic science, with applications in drug identification, forensic toxicology, and latent fingerprint detection and ...
Dos Santos Martins G, Dos Santos Dupim M, Garcia Agostinho R, Gadini Finelli F.   +3 more
europepmc   +2 more sources

Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds

Angewandte Chemie, Volume 135, Issue 41, October 9, 2023., 2023
Charting the reaction space around a known Multicomponent Reaction (MCR) allows the development of new processes. In this way, a detailed study of the parameters involved in the Orru transformation leads to the generation of alternative connectivities featuring diversely substituted imidazolones, including GFP (Green Fluorescent Protein) chromophores ...
Pau Nadal Rodríguez, Ouldouz Ghashghaei, Anna M. Schoepf, Sam Benson, Marc Vendrell, Rodolfo Lavilla   +5 more
wiley   +2 more sources

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

BMEMat, Volume 3, Issue 4, December 2025.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang, Yefei Dai, Yujun Hou, Joshua Stein, Shichen Steven Lin, Chaochen Zhou, Yannan Hou, Rongrong Zhu, Ki‐Bum Lee, Letao Yang   +9 more
wiley   +1 more source

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery

Advanced Science, Volume 12, Issue 30, August 14, 2025.
Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang, Yujian Liu, Chenchen Li, Bin Xu, Shidang Xu, Bin Liu   +5 more
wiley   +1 more source

A Systematic Review of the Costs of Drug‐Associated Acute Kidney Injury and Potential Cost Savings With Nephrotoxin Stewardship Prevention Strategies

Clinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 989-1004, April 2025.
There is a scarcity of information related to the financial impact of acute kidney injury (AKI), and even more so the economics of drug‐associated AKI (D‐AKI). Our goal was to provide a comprehensive summary of the economic burden of D‐AKI by evaluating the costs of D‐AKI compared to not developing AKI and cost savings associated with nephrotoxin ...
Britney A. Stottlemyer, Tiffany Tran, Kangho Suh, Sandra L. Kane‐Gill   +3 more
wiley   +1 more source

Total Synthesis of Discobahamin A and Putative Structure of Discobahamin B via an Isocyanide‐based Macrocyclization Reaction

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
An isocyanide‐based macrocyclization, involving the formation of a C(sp3)‐C(sp2) bond and the concurrent generation of an α‐acyloxy amide functional group, has been developed and successfully applied to the total synthesis of discobahamin A, a 24‐membered macrocyclopeptide. Abstract We report in this paper the first total synthesis of discobahamin A, a
Baochao Yang, Qian Wang, Jieping Zhu
wiley   +1 more source