Results 11 to 20 of about 65,761 (163)

Development of cytosine and adenine base editors for maize precision breeding. [PDF]

J Integr Plant Biol
A series of maize cytosine and adenine base editors was developed using various deaminase variants, enabling efficient multiplex genome editing in maize. Precise editing of the ZmACC1/2 genes generated herbicide‐tolerant maize germplasm, offering a solution for weed management in maize‐soybean intercropping systems.
Fu X, Wang N, Li L, Qiao D, Qi X, Liu C, Gao Z, Xie C, Zhu J.   +8 more
europepmc   +2 more sources

One-Pot Morita-Baylis-Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ-Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation. [PDF]

ChemSusChem
Sustainable one‐pot synthesis of functionalized γ‐hydroxy derivatives in deep eutectic solvents. A green, sequential CC/CX bond‐forming strategy enables diverse γ‐hydroxy derivatives via Morita–Baylis–Hillman and nucleophilic functionalization in ChCl/Gly deep eutectic solvent.
Ramos-Martín M, Del Río I, García-Álvarez J, Presa Soto A.   +3 more
europepmc   +2 more sources

Ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine)

Molbank, 2022
The new bis-heterocyclic compound ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine) (1) was synthesized in 73% overall yield in 1.5 hours via a pseudo-repetitive Ugi-Zhu five-component reaction, starting from ...
Roberto E. Blanco-Carapia, Enrique A. Aguilar-Rangel, Alejandro Islas-Jácome, Eduardo González-Zamora   +3 more
doaj   +1 more source

2-Benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

Molbank, 2023
The new polyheterocyclic compound, 2-benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, was synthesized by a sequential combination of 4-chlorobenzaldehyde, (1-phenyl-1H-1,2,3 ...
Perla Islas-Jácome, Cecilia García-Falcón, Sandra L. Castañón-Alonso, Ernesto Calderón-Jaimes, Daniel Canseco-González, Alejandro Islas-Jácome, Eduardo González-Zamora   +6 more
doaj   +1 more source

Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds

Angewandte Chemie, Volume 135, Issue 41, October 9, 2023., 2023
Charting the reaction space around a known Multicomponent Reaction (MCR) allows the development of new processes. In this way, a detailed study of the parameters involved in the Orru transformation leads to the generation of alternative connectivities featuring diversely substituted imidazolones, including GFP (Green Fluorescent Protein) chromophores ...
Pau Nadal Rodríguez, Ouldouz Ghashghaei, Anna M. Schoepf, Sam Benson, Marc Vendrell, Rodolfo Lavilla   +5 more
wiley   +2 more sources

Ferrocene-derived P,N ligands : synthesis and application in enantioselective catalysis [PDF]

, 2013
Due to their unique steric and electronic properties, air-stability and modular structure, chiral hybrid P,N-ferrocenyl ligands play a prominent role in the field of asymmetric catalysis.
Noël, Timothy, Van der Eycken, Johan
core   +1 more source

Chiral N β-Fmoc-amino alkyl isonitriles in Ugi-4CR: An assembly of novel 1,1â²-iminodicarboxylated peptidomimetics [PDF]

, 2012
Enantiopure N β-Fmoc-amino alkyl isonitriles and amino acid esters have been employed as building blocks in Ugi four-component reaction (U-4CR) to yield 1,1â²-iminodicarboxylated peptidomimetics.
Nagendra, G., Narendra, N., Sureshbabu, V.V., Vishwanatha, T.M.   +3 more
core   +2 more sources

Synthesis of Unique Bioactive Alkaloids by Ugi Four-Component One-Pot Reaction

University Chemistry, 2020
: Using α -amino acids, aldehydes, isocyanides and alcohols as the starting materials, four components react in one pot at room temperature to obtain naturally unique bioactive alkaloids, 1,1’-iminodicarboxylic acid derivatives.
Houjin Li, Yang Xu, Y. Zhong, Xiaoyan Zhang, Fangmeng Zhu, Liuping Chen   +5 more
semanticscholar   +1 more source

Synthesis of beta-lactam peptidomimetics through Ugi MCR: first application of chiral N-beta-Fmoc amino alkyl isonitriles in MCRs [PDF]

, 2011
Chiral N-beta-Fmoc amino alkyl isonitriles were employed in Ugi multi component reactions (Ugi 4C-3CR) to obtain functionalized beta-lactam peptidomimetics with L-aspartic acid alpha-methyl ester/peptide ester and organic aldehydes.
Narendra, N., Sureshbabu, V.V., Vishwanatha, T.M.   +2 more
core   +2 more sources

Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones [PDF]

, 2015
A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described.
Abdelaziz El Maatougui, Armando Navarro-Vázquez, Armstrong R. W., Atkins R. J., Azuaje A., Baerends E. J., Bateson A. N., Belvisi L., Bolli M. H., Carlier P. R., Carlier P. R., Christian F. Masaguer, Cuny G., De Clerq E., De Silva R. A., Donald J. R., Dourlat J., Dömling A., Eddy Sotelo, Eichkorn K., Ettari R., Evans B. E., Gilman N. G., Gordon C. P., Guggenhem K. G., He P., Horton D. A., Hsu D. C., Huang Y., Jensen F., Jhonny Azuaje, José Carlos González-Gomez, José M. Pérez-Rubio, Keating T. A., Kleemann A., Kutzelnigg W., Lam P. C. H., Lecinska P., Linscheid P., Lodewyk M. W., Marcaccini S., Marcaccini S., Marta Teijeira, Micale N., Neese F., Petrovich A. G., Sañudo M., Schaefer A., Shaabani A., Shaabani A., Sinnecker S., Smith S. G., Smith S. G., Tempest P., Vicente Yaziji, Vı́ctor M. Sánchez-Pedregal, Weigend F., Xu J., Yang S. K., Zhang Y., Zhu J.   +60 more
core   +6 more sources