Beyond seek and destroy: How to generate allelic series using genome editing tools [PDF]
, 2020 Genome editing tools have greatly facilitated the functional analysis of genes of interest by targeted mutagenesis. Many usable genome editing tools, including different site-specific nucleases and editor databases that allow single-nucleotide ...
Bes, Martine +10 more
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An Ugi Reaction Incorporating a Redox-Neutral Amine C-H Functionalization Step.
Organic Letters, 2016 Pyrrolidine and 1,2,3,4-tetrahydroisoquinoline (THIQ) undergo redox-neutral α-amidation with concurrent N-alkylation upon reaction with aromatic aldehydes and isocyanides.
Zhengbo Zhu, D. Seidel
semanticscholar +1 more source
Direct polymerization of levulinic acid via Ugi multicomponent reactiont [PDF]
, 2016 A robust, direct and efficient approach has been developed for the utilization of levulinic acid (LevA) as a building block in the synthesis of polyamides.
Alonso +38 more
core +1 more source
Design e síntese de nanopartículas magnéticas funcionalizadas com peptóides para a remoção de cromo de resíduos aquosos [PDF]
, 2015 Dissertação (mestrado)–Universidade de Brasília, Faculdade UnB Planaltina, Mestrado em Ciência de Materiais, 2015.No presente trabalho realizou-se a síntese de nanopartículas magnéticas de óxido de ferro que foram funcionalizadas com peptóides.
Costa, Hingrid Lorrane Vieira da
core +1 more source
Organic Letters, 2019 Here we report an organocatalytic double Ugi reaction combining the enantioselective process and ee enhancement in a single operation to afford the chiral Ugi products with very high ee values.
Qi-Yun Feng +3 more
semanticscholar +1 more source
Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release. [PDF]
, 2018 Termination of protein synthesis is triggered by the recognition of a stop codon at the ribosomal A site and is mediated by class I release factors (RFs).
Clementi, Nina +11 more
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Stereospecific synthesis of syn-alpha-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids [PDF]
, 2011 A stereospecific multicomponent reaction among isocyanides, nitrile N-oxides and carboxylic acids provides an efficient synthesis of biologically relevant syn \u3b1 ...
Galli, Simona +3 more
core +1 more source
Concise Synthesis of Macrocycles by Multicomponent Reactions [PDF]
, 2018 A short reaction pathway was devised to synthesize a library of artificial 18-27-membered macrocycles. The five-step reaction sequence involves ring opening of a cyclic anhydride with a diamine, esterification, coupling with an amino acid isocyanide ...
Abdelraheem, Eman M. M. +2 more
core +2 more sources
Multicomponent synthesis of 4,4-dimethyl sterol analogues and their effect on eukaryotic cells [PDF]
, 2014 Most sterols, such as cholesterol and ergosterol, become functional only after the removal of the two methyl groups at C-4 from their biosynthetic precursors.
Alonso, Fernando +7 more
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Experimental and theoretical studies on the effect of the oxo group in 1,4-benzodiazepines [PDF]
, 2014 Two families of regioisomeric 1,4-benzodiazepines, 4-benzyl-3H-benzo[e][1,4]diazepin-5-ones and 4-benzoyl-4,5-dihydro-3H-benzo[e][1,4]diazepines, have been synthesized through a similar Ugi/reduction cyclization sequence. Their conformation and stability
Cordero Tejedor, Nicolás A. +5 more
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