Results 161 to 170 of about 12,153 (191)

The association of UGT1A1*6 and UGT1A1*28 with irinotecan-induced neutropenia in Asians: a meta-analysis

Biomarkers, 2013
The UGT1A1*28 polymorphism is known as a biomarker of irinotecan-induced neutropenia in Caucasians. However, in Asians, the UGT1A1*28 mutation is much less frequent.A meta-analysis was performed to assess the association of the UGT1A1*6 and UGT1A1*28 with neutropenia in Asians.In a combination test of the two variations, patients with severe ...
Yi-Jing, Chen, Fei, Hu, Chun-Yan, Li, Jue-Min, Fang, Li, Chu, Xi, Zhang, Qing, Xu   +6 more
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Pharmacokinetics of Raltegravir in Individuals With UGT1A1 Polymorphisms

Clinical Pharmacology & Therapeutics, 2009
Raltegravir is a human immunodeficiency virus-1 (HIV-1) integrase strand transfer inhibitor metabolized by glucuronidation via UDP-glucuronosyltransferase 1A1 (UGT1A1). In this study, 30 subjects with a UGT1A1*28/*28 genotype (associated with decreased activity of UGT1A1) and 27 UGT1A1*1/*1 control subjects (matched by race, age, gender, and body mass ...
L A, Wenning, A S, Petry, J T, Kost, B, Jin, S A, Breidinger, I, DeLepeleire, E J, Carlini, S, Young, T, Rushmore, F, Wagner, N M, Lunde, F, Bieberdorf, H, Greenberg, J A, Stone, J A, Wagner, M, Iwamoto   +15 more
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Accurate identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) inhibitors using UGT1A1-overexpressing HeLa cells

Xenobiotica, 2015
1. UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an irreplaceable role in detoxification of bilirubin and many drugs (e.g., SN-38). Here we aimed to explore the potential of UGT1A1-overexpressing HeLa cells (or HeLa1A1 cells) as a tool to accurately identify UGT1A1 inhibitors. 2.
Hua, Sun, Xiaotong, Zhou, Baojian, Wu
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Genetic determinants of UGT1A1 inducibility

Clinical Pharmacology & Therapeutics, 2005
Background UGT1A1 is induced by phenobarbital (PB). This study investigates whether the TATA box indel and two SNPs in the PBREM region are associated with the variability in the inductive phenotype. Methods Human hepatocytes (n=36) were incubated with 2 mM PB (48 h) followed by 5 μM SN-38 (1 h), a UGT1A1 probe.
J RAMIREZ, F INNOCENTI, B KOMOROSKI, S MIRKOV, A YODERGRABER, D FACKENTHAL, S DAS, E SCHUETZ, S STROM, M RATAIN   +9 more
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Role of UGT1A1 mutation in fasting hyperbilirubinemia

Journal of Gastroenterology and Hepatology, 2001
AbstractBackground and Aim:Low‐grade fasting hyperbilirubinemia is a common observation in healthy subjects (HS), whereas high‐grade fasting hyperbilirubinemia is believed to be a characteristic finding of Gilbert’s syndrome. This study was undertaken to assess the role of mutation in bilirubin UDP‐ glycosyltransferase gene (UGT1A1) on fasting ...
T, Ishihara, M, Kaito, K, Takeuchi, E C, Gabazza, Y, Tanaka, K, Higuchi, J, Ikoma, S, Watanabe, H, Sato, Y, Adachi   +9 more
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Role of UGT1A1*6 in Irinogenetics in Asians

Personalized Medicine, 2007
Evaluation of: Jada SR, Lim R, Wong CI et al.: Role ofUGT1A1*6, UGT1A1*28 and ABCG2 c.421C>A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients. Cancer Sci. 98(9), 1461-1467 (2007). The pharmacokinetics and toxicity of irinotecan vary widely among patients.
Tae Won, Kim, Federico, Innocenti
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การพัฒนาเทคนิคไพโรซีเควนซิ่งสาหรับการตรวจความหลากหลายทางพันธุกรรมของยีน UGT1A1 ในผู้ป่วยไทยที่เป็นมะเร็งลาไส้ใหญ่

2013
S1 (Special Issue 1), S.1, Thai Journal of ...
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Severe Neonatal Hyperbilirubinemia and UGT1A1 Promoter Polymorphism

The Journal of Pediatrics, 2014
To assess whether UGT1A1 promoter polymorphisms associated with Gilbert Syndrome (GS) occur with a greater frequency in neonates with severe hyperbilirubinemia.In a case-control study performed at a single hospital center in Italy, 70 case subjects with severe hyperbilirubinemia (defined as bilirubin level ≥20 mg/dL or 340 μmol/L) and 70 controls ...
Laura Travan, LEGA, SARA, CROVELLA, SERGIO, Marcella Montico, Elisa Panontin, Sergio Demarini   +5 more
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UGT1A1*28 polymorphism influences glucuronidation of bazedoxifene

Die Pharmazie, 2015
Bazedoxifene is used for the prevention and treatment of osteoporosis. After peroral application, bazedoxifene is metabolized by UDP-glucuronosyltransferases (UGTs) to bazedoxifene-4'-glucuronide (M4) and bazedoxifene-5-glucuronide (M5). It has already been shown that a relatively common UGT1A1*28 polymorphism can considerably affect raloxifene ...
Trdan Lusin, T., Mrhar, A., Trontelj, J.
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UGT1A1*28 polymorphism in ovarian cancer patients

Oncology Reports, 2004
(Uridino-diphosphate)glucuronosyl-transferase enzyme 1A1 isoform (UGT1A1) is involved in glucuronidation of antineoplastic drugs such as SN38, the active metabolite of irinotecan, as well as estrogens and their metabolites. UGT1A1*28 polymorphism decreases UGT1A1 expression and could alter estrogens disposition influencing tumour growth in hormone ...
Erika, Cecchin, Antonio, Russo, Giuseppe, Corona, Elio, Campagnutta, Luca, Martella, Mauro, Boiocchi, Giuseppe, Toffoli   +6 more
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