Results 31 to 40 of about 308,100 (168)

Superior reductions in hepatic steatosis and fibrosis with co-administration of a glucagon-like peptide-1 receptor agonist and obeticholic acid in mice

Molecular Metabolism, 2017
Objective: Nonalcoholic steatohepatitis (NASH) is an unmet need associated with metabolic syndrome. There are no approved therapies for NASH; however, glucagon-like peptide-1 receptor (GLP-1R) and farnesoid-X receptor (FXR) agonists are promising drug ...
Hani Jouihan, Sarah Will, Silvia Guionaud, Michelle L. Boland, Stephanie Oldham, Peter Ravn, Anthony Celeste, James L. Trevaskis   +7 more
doaj   +1 more source

Budesonide Foam Has a Favorable Safety Profile for Inducing Remission in Mild-to-Moderate Ulcerative Proctitis or Proctosigmoiditis. [PDF]

, 2015
BackgroundBudesonide foam, a rectally administered, second-generation corticosteroid with extensive hepatic first-pass metabolism, is efficacious for the treatment of mild-to-moderate ulcerative proctitis and ulcerative proctosigmoiditis.AimThe aim of ...
Barrett, Andrew C, Bortey, Enoch, Bosworth, Brian, Forbes, William P, Golden, Pamela L, Gordon, Glenn L, Rolleri, Robert L, Rubin, David T, Sale, Mark E, Sandborn, William J, Zakko, Salam   +10 more
core   +3 more sources

Balancing constraints and requirements in an application process

International Journal of Population Data Science
Objectives Developing a rigorous application process for linked data within the UK Longitudinal Linkage Collaboration’s Trusted Research Environment (TRE) included balancing the requirements of >20 longitudinal studies and several data providers with ...
Stela McLachlan, Katharine Evans, Rebecca Whitehorn, Emma Turner, Jacqueline Oakley, Andy Boyd, Robin Flaig   +6 more
doaj   +1 more source

The Analysis of the Bankruptcy Procedures of Legal Entities in Russia in the Years 2010-2016

Учёт. Анализ. Аудит, 2019
The article discusses the dynamics of the enterprises that are being opened or liquidated due to bankruptcy in Russia in 2010-2016. A detailed analysis of the changes and observed trends throughout the study period is conducted in the article ...
Ekaterina Adreevna Karzaeva
doaj   +1 more source

The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies

Engineering Reports, 2020
The development of therapeutic monoclonal antibodies (mAbs) can be hindered by their tendency to aggregate throughout their lifetime, which can illicit immunogenic responses and render mAb manufacturing unfeasible.
Leon F. Willis, Amit Kumar, Tushar Jain, Isabelle Caffry, Yingda Xu, Sheena E. Radford, Nikil Kapur, Maximiliano Vásquez, David J. Brockwell   +8 more
doaj   +1 more source

Are Panel Unit Root Tests Useful for Real-Time Data? [PDF]

, 2010
With the development of real-time databases, N vintages are available for T observations instead of a single realization of the time series process. Although the use of panel unit root tests with the aim to gain in efficiency seems obvious, empirical and
Augustijn-Beckers, Petronella, Garg, P.K., Garg, R.D., Kandwal, R., Miscione, G., Stein, A.   +5 more
core   +6 more sources

A 28 Day Clinical Assessment of a Lactic Acid-containing Antimicrobial Intimate Gel Wash Formulation on Skin Tolerance and Impact on the Vulvar Microbiome

Antibiotics, 2020
While intimate feminine hygiene products are widely used as part of daily cleansing routines, little is known about how these products impact the vulvovaginal area and its microbiome stability. This 4 week clinical study assessed tolerance of a novel gel
Elizabeth Bruning, Ying Chen, Karen A. McCue, Joseph R. Rubino, Jeremy E. Wilkinson, Alan D. G. Brown   +5 more
doaj   +1 more source

In situ X-ray computed micro-tomography imaging of failure processes in Cr-coated Zircaloy nuclear fuel cladding materials

Materials & Design, 2023
Chromium (Cr)-coated Zircaloy fuel cladding has been considered a promising candidate materials system for accident tolerant fuels. In this work, two types of Cr coatings produced by cold sprayed (CS) and physical vapour deposited (PVD) methods were ...
Guanjie Yuan, J. Paul Forna-Kreutzer, Jon Ell, Harold Barnard, Benjamin R. Maier, Edward Lahoda, Jorie Walters, Robert O. Ritchie, Dong Liu   +8 more
doaj   +1 more source

Gut microbiota-derived propionate reduces cancer cell proliferation in the liver [PDF]

, 2012
Peer reviewedPublisher ...
A Everard, A M Neyrinck, AJ Brown, AS Neish, BF Hinnebusch, BL Pool-Zobel, C Cherbut, C Daubioul, C Sundstrom, E Le Poul, E M Dewulf, F Guarner, G G Muccioli, G Tolhurst, HS Taper, J Bray, J Busserolles, J C Martin, J Verrax, K P Scott, KM Maslowski, L B Bindels, LB Bindels, M Aoyama, M Montillo, MA Cox, MA Vinolo, N M Delzenne, NG Kondegowda, O Feron, P Buc Calderon, P D Cani, P Louis, P Porporato, P Sonveaux, P Sonveaux, PD Cani, PD Cani, R Alric, R Ren, S Siavoshian, T Lee, W Fiskus, Y Tang, Y Tang, Y Wang, YH Hong   +46 more
core   +1 more source

Bi-Lipschitz Pieces between Manifolds [PDF]

, 2013
A well-known class of questions asks the following: If $X$ and $Y$ are metric measure spaces and $f:X\rightarrow Y$ is a Lipschitz mapping whose image has positive measure, then must $f$ have large pieces on which it is bi-Lipschitz?
David, Guy C.
core