Results 91 to 100 of about 17,118 (204)

A systematic investigation on the response of EBT-XD gafchromic films to varying dose-per-pulse, average dose-rate and instantaneous dose-rate in electron flash beams

Frontiers in Physics
BackgroundThe FLASH effect is a radiobiological phenomena characterized by the reduction of the damage to healthy tissues while maintaining iso-effectiveness on the tumour, obtained by delivering the entire radiation dose in less than 100–200 m and with ...
D. Del Sarto, D. Del Sarto, L. Masturzo, L. Masturzo, A. Cavalieri, A. Cavalieri, M. Celentano, M. Celentano, T. Fuentes, T. Fuentes, G. Gadducci, G. Gadducci, N. Giannini, N. Giannini, A. Gonnelli, A. Gonnelli, G. Milluzzo, F. Paiar, F. Paiar, F. Paiar, J. H. Pensavalle, J. H. Pensavalle, F. Romano, F. Di Martino, F. Di Martino   +24 more
doaj   +1 more source

Red‐Light Tomographic Volumetric 3D Printing in Seconds for Fabrication of Colorless Structures

Advanced Materials Technologies, EarlyView.
A custom red‐light‐responsive TVAM platform combines methylene blue, triethanolamine, and PEGDA to fabricate transparent crosslinked hydrogels. Light patterns are projected into a rotating resin container, where a sacrificial photoinitiator system enables rapid polymerization and colorless channel‐containing structures, utilizing low‐energy light for ...
Ali Eftekhari, Qianyi Zhang, Shahla Radmehr, Felix Wechsler, Riccardo Rizzo, Ville Santala, Minna Kellomäki, Alexander Efimov, Timo Laaksonen, Christophe Moser   +9 more
wiley   +1 more source

Effects of whole brain proton irradiation at conventional or ultra-high dose rate (FLASH), in adult male Sprague Dawley rats

Scientific Reports
Radiation is an effective treatment for many brain tumors, but often causes cognitive impairment. Ultra-high dose rate (FLASH) radiotherapy is less toxic to many normal tissues and may protect against adverse cognitive effects of cranial irradiation ...
Michael T. Williams, Samantha L. Regan, Adam L. Fritz, Brooke M. Gollaway, Anthony E. Mascia, Ralph E. Vatner, John P. Perentesis, Charles V. Vorhees   +7 more
doaj   +1 more source

Single‐Step Fabrication of Smart 3D Microstructures Exploiting Naphthopyrans as Photoinitiators and Photochromic Molecules

Advanced Optical Materials, EarlyView.
Naphthopyran–benzophenone compounds can act simultaneously as photoinitiators and photochromic molecules for two‐photon polymerization. Using a single‐step process, liquid photoresist is encapsulated within polymerized 3D microstructures, preserving reversible UV–vis photochromism after fabrication.
João P. Leote, Artur Andrishak, Paulo J. Coelho, José R. Fernandes, Christian Maibohm, Jana B. Nieder   +5 more
wiley   +1 more source

Consensus statement on the exploration of clinical translation and application of electron ultra‐high dose rate FLASH radiotherapy

Precision Radiation Oncology
Ultra‐high dose rate FLASH Radiotherapy (FLASH‐RT) has attracted wide attention because the well‐known FLASH effect and the extremely short irradiation time.
Hui Luo, Chengliang Yang, Jinbo Yue, Hong Ge   +3 more
doaj   +1 more source

Force–Displacement Characterization of PNIPAM Microactuators

Advanced Robotics Research, EarlyView.
A method to experimentally establish a force–displacement diagram of poly(N‐isopropyl acrylamide) (PNIPAM) microactuators, printed by 2PP, is presented herein. PNIPAM is a hydrogel whose volume and stiffness change with temperature due to the absorption or release of water.
Manon Cassignol, Esra Yalcinkaya, Adam Chafaï, Jérémy Odent, Pierre Lambert   +4 more
wiley   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Characterization of the Intestinal Metabolic Profiles Following Photon FLASH Irradiation

Dose-Response
Objective Ultra-high dose rate radiotherapy, commonly referred to as FLASH radiotherapy, is a transformative focus in radiotherapeutic research. This study aimed to identify intestinal contents based metabolic biomarkers of photon FLASH. Methods C57BL/6J
Siqian Zhang, Qiliang Peng, Jun Zhang, Zhiming Wang, Xinyang Cheng, Yongsheng Zhang, Zhifei Cao   +6 more
doaj   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source