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ELUCIDATION OF THE MECHANISMS UNDERLYING ULTRA-HIGH DOSE RATE IRRADIATION

ELUCIDATION OF THE MECHANISMS UNDERLYING ULTRA-HIGH DOSE RATE IRRADIATION
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Ultra‐high dose rate FLASH radiation therapy for cancer

Medical Physics, 2023
AbstractConformality has been a key requirement in radiation therapy for cancer to minimize normal tissue toxicity while maintaining tumor control. Since 2014, there has been great interest in ultra‐high dose rate (UHDR), “FLASH,” radiation therapy to enhance this therapeutic window.
Michele M, Kim, Wei, Zou
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Ultra-high dose-rate proton FLASH improves tumor control

Radiotherapy and Oncology, 2023
Proton radiotherapy (PRT) offers potential benefits over other radiation modalities, including photon and electron radiotherapy. Increasing the rate at which proton radiation is delivered may provide a therapeutic advantage. Here, we compared the efficacy of conventional proton therapy (CONVpr) to ultrahigh dose-rate proton therapy, FLASHpr, in a mouse
Samriddhi Shukla, Taniya Saha, Nihar Rama, Anusha Acharya, Tien Le, Fenghua Bian, Johnny Donovan, Lin Abigail Tan, Ralph Vatner, Vladimir Kalinichenko, Anthony Mascia, John P. Perentesis, Tanya V. Kalin   +12 more
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FLASH ultra-high dose rates in radiotherapy: preclinical and radiobiological evidence

International Journal of Radiation Biology, 2021
Flash radiotherapy (FLASH-RT) is currently being regarded as the next breakthrough in radiation treatment of cancer, delivering ultrahigh radiation doses in a very short time, and sparing normal tissues from detrimental injury. Here we review the current evidence on the preclinical findings as well as the radiobiological mechanisms underlying the FLASH
Borghini A., Vecoli C., Labate L., Panetta D., Andreassi M., Gizzi L. A.   +5 more
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Ultra-high Dose-rate Effects in Radiosensitive Bacteria

International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1969
(1969). Ultra-high Dose-rate Effects in Radiosensitive Bacteria. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine: Vol. 14, No. 6, pp. 573-575.
T L, Phillips, B R, Worsnop
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Oxygen Depletion in Cells Irradiated at Ultra-high Dose-rates and at Conventional Dose-rates

International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1974
Irradiation at conventional dose-rates of an oxygen-equilibrated bacterial cell suspension in a sealed vessel produces breaking survival curves similar to those observed for cells irradiated as a t...
H, Weiss, E R, Epp, J M, Heslin, C C, Ling, A, Santomasso   +4 more
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Characterizing devices for validation of dose, dose rate, and LET in ultra high dose rate proton irradiations

Medical Physics
AbstractBackgroundUltra high dose rate (UHDR) radiotherapy using ridge filter is a new treatment modality known as conformal FLASH that, when optimized for dose, dose rate (DR), and linear energy transfer (LET), has the potential to reduce damage to healthy tissue without sacrificing tumor killing efficacy via the FLASH effect.PurposeClinical ...
Nathan, Harrison, Serdar, Charyyev, Cristina, Oancea, Alexander, Stanforth, Edgar, Gelover, Shuang, Zhou, William S, Dynan, Tiezhi, Zhang, Steven, Biegalski, Liyong, Lin   +9 more
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Modifying a Clinical Linear Accelerator for Delivery of Ultra-High Dose Rate Irradiation

Radiotherapy and Oncology, 2019
The purpose of this study was to modify a clinical linear accelerator, making it capable of electron beam ultra-high dose rate (FLASH) irradiation. Modifications had to be quick, reversible, and without interfering with clinical treatments.Performed modifications: (1) reduced distance with three setup positions, (2) adjusted/optimized gun current ...
Gabriel Adrian, Kristoffer Petersson, Crister Ceberg   +2 more
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Toxicity of hadrontherapy at ultra-high dose rate

Toxicité de la hadronthérapie à ultra-haut débit de dose La radiothérapie à Ultra-Haut Débit de Dose (RT-UHDD), de l’ordre du Gray/msec, est une technique prometteuse pour réduire la toxicité aux tissus sains. Par ailleurs, la balistique des hadrons (protons/ions d'hélium) permet un meilleur ciblage des tumeurs, limitant la dose ...
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Advances in ultra-high dose rate radiation therapy

Enger, Shirin Abbasi Nejad (Supervisor1)
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