Results 221 to 230 of about 151,242 (304)

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

Improvement of small extracellular vesicle isolation from mouse model blood. [PDF]

Extracell Vesicles Circ Nucl Acids
Venturini G, Ferrante A, Carlo ND, Bertuccini L, Iosi F, Condello M, Martire A, Fratini F, Boussadia Z.   +8 more
europepmc   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

Development of a Novel Extracellular Vesicle-Based Biomarker Approach for Pediatric High-Grade Glioma. [PDF]

J Extracell Biol
Fernandez Garcia A, Iyer P, Ashi P, Tella I, Sangaraboina V, Bhagat D, Janarthanam C, Bargues-Carot A, Kanthasamy AG, Spoerer T, Golan ME, Stice SL, Funato K.   +12 more
europepmc   +1 more source

Optimization of Microfluidic Geometry for Extracellular Vesicle Capture Using an Automated Parallel Pattern Search

PROTEOMICS, EarlyView.
ABSTRACT Microfluidic affinity‐based capture of extracellular vesicles (EVs) holds great promise for disease diagnostics and monitoring therapeutic EV production. However, optimizing microfluidic channel geometries for efficient EV capture remains understudied due to the effort required to experimentally test numerous designs.
Arvin Lim, A. J. Tyler, Isha Nayyar, Larry W. Chamley, Cherie Blenkiron, Colin L. Hisey, Richard J. Clarke   +6 more
wiley   +1 more source

Isolation and proteomic analysis of intracellular vesicles from the potato late blight pathogen Phytophthora infestans. [PDF]

Sci Rep
Pham J, Whisson SC, Hurst CH, Chapman S, Birch PRJ.   +4 more
europepmc   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Current Insight into Human Ornithine Aminotransferase: A Review

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human ornithine aminotransferase (hOAT) is a mitochondrial matrix pyridoxal‐5′‐phosphate enzyme (PLP) that catalyzes the reversible transfer of the δ‐amino group of L‐ornithine (L‐Orn) to α‐ketoglutarate (α‐KG) yielding glutamate‐5‐semialdehyde (GSA) and glutamate. GSA is prone to cyclize to Δ1‐pyrroline‐5‐carboxylate.
Fulvio Floriani, Carla Borri Voltattorni, Riccardo Montioli   +2 more
wiley   +1 more source

Usefulness of plasma and apolipoprotein B-depleted serum samples in paraoxonase 1 assessment. [PDF]

Biochem Biophys Rep
Kawaguchi R, Yoshimoto A, Kameda T, Ohkawa R.   +3 more
europepmc   +1 more source

Liquid Biopsy Differentiation of Pancreatic Cancer From Non‐Cancerous Pancreatic Disease Using Dielectrophoresis‐Recovered Nanoparticles Carrying Cell‐Free DNA and Protein Biomarkers

Small, EarlyView.
A new nanoparticle‐based biomarker panel is described that can differentiate pancreatic cancer from benign pancreatic disease with a high level of performance. This was enabled by microelectrode array recovery technology that used dielectrophoresis (DEP) to quickly and efficiently recover the nanoparticles from patient plasma samples, followed by on ...
Anna Malakian, Augusta Modestino, Jesus Bueno, Archana Machireddy, Jason Ware, Sean Hamilton, Ella Stimson, Sarah Mitchell, Joshua C. Saldivar, Ashley R. Woodfin, Corey M. Dambacher, Kyle Gustafson, Delaney Shea, Srivathsan Ranganathan, Mehrzad Sasanpour, Christian Ross, Dove Keith, Jeong Youn Lim, Xubo Song, Scott M. Lippman, Rosalie Sears, Terry Morgan, Michael Heller, Stuart D. Ibsen   +23 more
wiley   +1 more source