Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]
, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris +7 more
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Cholesterol nucleation time in gallbladder bile of patients with solitary or multiple cholesterol gallstones [PDF]
, 1992 Patients with multiple cholesterol gallbladder stones have been found to be at a higher risk for the recurrence of gallstones after successful nonsurgical treatment than those with a solitary stone.
Abell +27 more
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Journal of Extracellular Vesicles, 2021 The molecular characterization of extracellular vesicles (EVs) has revealed a great heterogeneity in their composition at a cellular and tissue level.
Juan A. Martínez‐Greene +10 more
doaj +1 more source
1Progress, applications, challenges and prospects of protein purification technology
Frontiers in Bioengineering and Biotechnology, 2022 Protein is one of the most important biological macromolecules in life, which plays a vital role in cell growth, development, movement, heredity, reproduction and other life activities.
Miao Du +9 more
doaj +1 more source
Разработка и регистрация лекарственных средств, 2020 Introduction. Drug encapsulation efficiency (EE) is the important parameter of the nanoparticle-based drug formulations. Generally, the methods for evaluation of the EE are based on separation of the free and NP-bound fractions of the drug; however ...
T. S. Kovshova +6 more
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Crystallization of Adenylylsulfate Reductase from Desulfovibrio gigas: A Strategy Based on Controlled Protein Oligomerization [PDF]
, 2011 Adenylylsulfate reductase (adenosine 5′-phosphosulfate reductase, APS reductase or APSR, E.C.1.8.99.2) catalyzes the conversion of APS to sulfite in dissimilatory sulfate reduction. APSR was isolated and purified directly from massive anaerobically grown
Chan, Sunney I. +9 more
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یافتههای نوین در علوم زیستی, 2022 Nowadays, researchers have made extensive efforts to find new treatments for nerve damage. Meanwhile, the role of exosomes in cell-cell communication is considered to be a new mechanism. Exosomes can act as suitable differentiating agents.
Mojtaba Cheravi +3 more
doaj
Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles [PDF]
, 2013 We previously reported that the incorporation of tissue factor (TF) into cell-derived microvesicles (MVs) is regulated by the phosphorylation of the cytoplasmic domain of TF.
Collier, Mary E. W. +2 more
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Production- and Purification-Relevant Properties of Human and Murine Cytomegalovirus
Viruses, 2021 There is a large unmet need for a prophylactic vaccine against human cytomegalovirus (HCMV) to combat the ubiquitous infection that is ongoing with this pathogen.
Sanda Ravlić +4 more
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Nitrogen Oxyanion-dependent Dissociation of a Two-component Complex That Regulates Bacterial Nitrate Assimilation [PDF]
, 2013 Nitrogen is an essential nutrient for growth and is readily available to microbes in many environments in the form of ammonium and nitrate. Both ions are of environmental significance due to sustained use of inorganic fertilizers on agricultural soils ...
Goldman +6 more
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