Results 101 to 110 of about 74,323 (305)
eGFR slope as predictor of mortality in heart failure patients
ESC Heart Failure, Volume 12, Issue 2, Page 1217-1226, April 2025.Abstract Aims Heart failure (HF) leads to an imbalance between heart and kidney function, resulting in poor outcomes. However, the prognostic significance of the estimated glomerular filtration rate (eGFR) trajectory in HF patients remains unclear. We analysed electronic health records (EHRs) of real‐world HF patients, assessing eGFR trajectories and ...
Sofie Verstreken +10 more
wiley +1 more source
System Analysis to UML – Restaurant Case Study
, 2022 Nilesh D Kulkarni +3 more
openalex +1 more source
Epilepsia Open, EarlyView.Abstract Objective Late‐onset unexplained epilepsy (LoUE), defined as epilepsy onset after age 55 without an obvious cause, is an important risk factor for dementia. Studies have shown that 10%–25% of individuals with LoUE develop dementia within 3–4 years following their first seizure.
Alice D. Lam +13 more
wiley +1 more source
Small Science, EarlyView.Fluorescent dye labeling enables nanoparticle imaging but may subtly alter their surface chemistry and biological behavior. This study compares dye‐labeled and unlabeled cerium oxide nanozymes, revealing changes in cellular uptake kinetics without affecting their final intracellular fate. Combined fluorescence and label‐free electron microscopy imaging
Kanika Dulta +3 more
wiley +1 more source
Systems Engineering, EarlyView.ABSTRACT System of Systems (SoS) environments are inherently complex, involving numerous operationally and managerially independent component systems with hidden interdependencies and frequent interactions based on unstructured data. In this paper, we propose using graphical Retrieval‐Augmented Generation (GraphRAG), a tool that combines large language
Yinchien Huang +2 more
wiley +1 more source
An extensible formal semantics for UML activity diagrams [PDF]
, 2016 Zamira Daw, Rance Cleaveland
openalex +1 more source
Identification of Missing Knowledge in MBSE System Models Using Graph‐Based Machine Learning
Systems Engineering, EarlyView.ABSTRACT The design and development of complex aerospace systems pose significant challenges due to their growing complexity. Iterative design processes, guided by formal specifications, strive to refine initially vague characteristics through multiple stages.
Esma Karagoz +2 more
wiley +1 more source
Mission Aware Cyber‐Physical Security
Systems Engineering, EarlyView.ABSTRACT Perimeter cybersecurity, while essential, has proven insufficient against sophisticated, coordinated, and cyber‐physical attacks. In contrast, mission‐centric cybersecurity emphasizes finding evidence of attack impact on mission success, allowing for targeted resource allocation to mitigate vulnerabilities and protect critical assets.
Georgios Bakirtzis +3 more
wiley +1 more source
A Bibliometric Review of the INCOSE's Model‐Based Systems Engineering Roadmap
Systems Engineering, EarlyView.ABSTRACT Over the past decade, model‐based systems engineering (MBSE) has gained attention as an approach for managing system complexity, offering a shift from a document‐based to a model‐based approach. The International Council on Systems Engineering (INCOSE) sparked increasing interest when it introduced MBSE and its roadmap as part of its systems ...
Marjolein Antoinette Jannyne Velthuizen +2 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz +8 more
wiley +1 more source