Results 111 to 120 of about 193,599 (260)

MBSE Co‐Pilot: A Research Roadmap

open access: yesSystems Engineering, EarlyView.
ABSTRACT As the complexity of engineered systems continues to increase, Model‐Based Systems Engineering (MBSE) methodologies, languages, and tools are increasingly insufficient to meet the demands of modern systems engineering. This paper proposes a research roadmap for the development of an AI‐driven machine, referred to as MBSE Co‐Pilot, designed to ...
Wenheng Zhang   +6 more
wiley   +1 more source

Addressing Complexity in System of Systems With GraphRAG: An AI‐Driven Framework for Dynamic Data Integration

open access: yesSystems Engineering, EarlyView.
ABSTRACT System of Systems (SoS) environments are inherently complex, involving numerous operationally and managerially independent component systems with hidden interdependencies and frequent interactions based on unstructured data. In this paper, we propose using graphical Retrieval‐Augmented Generation (GraphRAG), a tool that combines large language
Yinchien Huang   +2 more
wiley   +1 more source

Comprehensibility of UML-based Formal Model – A Series of Controlled Experiments

open access: yes, 2007
This paper summarises two controlled experiments conducted on a model that integrates the use of semi-formal notation, the Unified Modelling Language (UML) and a formal notation, B.
Poppleton, M. R.   +2 more
core  

Identification of Missing Knowledge in MBSE System Models Using Graph‐Based Machine Learning

open access: yesSystems Engineering, EarlyView.
ABSTRACT The design and development of complex aerospace systems pose significant challenges due to their growing complexity. Iterative design processes, guided by formal specifications, strive to refine initially vague characteristics through multiple stages.
Esma Karagoz   +2 more
wiley   +1 more source

Can unsupervised machine learning gain new insights into urodynamic pressure flow pattern analysis?

open access: yesBJU International, EarlyView.
Objectives To explore the use of unsupervised machine learning (UML) to analyse segments of the pressure flow study (PFS) curve after maximum flow, and subsequently to analyse the urodynamic and patient characteristics of men in the detected clusters. Subjects and Methods In this study, we considered 1650 PFSs of men with lower urinary tract symptoms ...
Wouter van Dort   +4 more
wiley   +1 more source

A Unified Modeling Language-Based Design And Application For A Library Management Information System

open access: yesCybernetics and Information Technologies, 2014
This paper firstly introduces the main content of the Unified Modeling Language (UML) and proves that it can transmit information among the users, the developers, the designers and the managers efficiently, which improves their collaboration capabilities
Zheng Jianhu, Feng Yunqing, Zhao Yun
doaj   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

open access: yesBritish Journal of Pharmacology, EarlyView.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez   +13 more
wiley   +1 more source

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