Results 51 to 60 of about 74,323 (305)

Selected Topics on Business Information Systems Research: Editorial Introduction to Issue 26 of CSIMQ

Complex Systems Informatics and Modeling Quarterly, 2021
Business Information Systems research deals with the conceptualization, development, introduction, maintenance and utilization of systems for computer-assisted information processing within companies and enterprise-wide networks.
Ben Roelens
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Domain Modeling in the Context of Ontology

Foundations of Computing and Decision Sciences, 2015
The domain knowledge represented by ontology should be widely used in the design process of information system. The aim of the paper is to outline a systematic approach of developing a CIM model (domain model, precisely) on the basis of a selected domain
Dubielewicz Iwona, Hnatkowska Bogumiła, Huzar Zbigniew, Tuzinkiewicz Lech   +3 more
doaj   +1 more source

Data Object Modeling for Depreciation System Using UML [PDF]

Al-Rafidain Journal of Computer Sciences and Mathematics, 2004
Data object modeling is considered the most effective style in data manipulation. This style provides the ability to decompose complex systems into parts, these parts can be manipulated simply, understanding, accuracy with easy updating reducing run time
Asmaa Hammo, Alaa Saeed
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Rancang Bangun Sistem Manajemen Ban Berbasis Web Pada Heavy Equipment Maintenance Departemen Quarry

Jurnal Mekanik Terapan, 2021
Ban adalah salah satu komponen penting dalam pertambangan khususnya alat angkut/alat berat pada PT SBI. Guna memenuhi tuntutan produksi diperlukan jam kerja yang tinggi dari alat angkut, menyebabkan kinerja dari ban semakin berat dan berisiko untuk ...
Ibnu Hakim, Sonki Prasetya, Aris Hendratmoko   +2 more
doaj   +1 more source

Can unsupervised machine learning gain new insights into urodynamic pressure flow pattern analysis? [PDF]

BJU Int
Objectives To explore the use of unsupervised machine learning (UML) to analyse segments of the pressure flow study (PFS) curve after maximum flow, and subsequently to analyse the urodynamic and patient characteristics of men in the detected clusters. Subjects and Methods In this study, we considered 1650 PFSs of men with lower urinary tract symptoms ...
van Dort W, Rosier PFWM, van Steenbergen TRF, Geurts BJ, de Kort LMO.   +4 more
europepmc   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Barcode Based Digital Library Information System Application (Case Study: SMA Yadika 3 Karang Tengah)

Journal of Information Systems and Informatics, 2020
Perpustakaan SMA Yadika 3 Karang Tengah memiliki jumlah anggota dan koleksi buku yang begitu banyak, hal ini membuatnya sangat membutuhkan sebuah aplikasi perpustakaan digital yang berguna untuk membantu kinerja petugas perpustakaan.
Afrinaldi Afrinaldi, Yuwan Jumaryadi
doaj   +1 more source

Construction of Fuzzy Ontologies from Fuzzy UML Models [PDF]

International Journal of Computational Intelligence Systems, 2013
The success and proliferation of the Semantic Web depends heavily on construction of Web ontologies. However, classical ontology construction approaches are not sufficient for handling imprecise and uncertain information that is commonly found in many ...
Fu Zhang, Z. M. Ma
doaj   +1 more source