Results 31 to 40 of about 85,519 (230)

Prevalence of psychoactive substance use by adolescents in public schools in a municipality in the São Paulo Metropolitan Area, Brazil

open access: yesCadernos de Saúde Pública, 2023
This study aimed to estimate the prevalence of psychoactive substance use by adolescents from public schools. This is a cross-sectional study that used a random sample of adolescents from five public schools located in a municipality in the central-west ...
Eliana Pereira Vellozo   +9 more
doaj   +1 more source

Łukasz Kamieński, Shooting Up: A Short History of Drugs and War.

open access: yesOpen Cultural Studies, 2019
From alcohol to LSD, Łukasz Kamieński takes readers on a unique 300-page journey through the history of warfare as seen through the prism of drug use. Beginning with the Greek city-states and ending with the contemporary consumption in the American Armed
Zmarzlinski Adam
doaj   +1 more source

Comparison of Outcomes among Adult Patients with Nosocomial Bacteremia Caused by Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus: A Retrospective Cohort Study. [PDF]

open access: yesPLoS ONE, 2015
Several studies have shown that patients with bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) have worse outcomes than those with bacteremia caused by methicillin-susceptible S. aureus (MSSA).
Jann-Tay Wang   +4 more
doaj   +1 more source

A novel candidate hepatitis C virus genotype 4 subtype identified by next generation sequencing full-genome characterization in a patient from Saudi Arabia

open access: yesFrontiers in Microbiology, 2023
Background and aimHepatitis C virus (HCV) infection is a major global public health concern, being a leading cause of chronic liver diseases such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma.
Mariantonietta Di Stefano   +9 more
doaj   +1 more source

Unveiling the Kinomes of Leishmania infantum and L. braziliensis Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds

open access: yesComputational and Structural Biotechnology Journal, 2019
Leishmaniasis is a neglected tropical disease caused by parasites of the genus Leishmania (NTD) endemic in 98 countries. Although some drugs are available, current treatments deal with issues such as toxicity, low efficacy, and emergence of resistance ...
Joyce V.B. Borba   +7 more
doaj   +1 more source

Detecting and managing small bowel Crohn’s disease – capsule endoscopy becoming a first line diagnostic method? [PDF]

open access: yes, 2011
Small bowel endoscopy is crucial for diagnosing small bowel Crohn’s disease, and capsule endoscopy is complemented by balloon-assisted enteroscopy to take biopsies and by magnetic resonance imaging to visualize enteral and extra-intestinal involvement ...
Albert, Jörg Gerhard   +1 more
core   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

open access: yesHepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran   +17 more
wiley   +1 more source

Hot-spot analysis for drug discovery targeting protein-protein interactions [PDF]

open access: yes, 2018
Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging.
Fernández-Recio, Juan, Rosell, Mireia
core   +2 more sources

Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.

open access: yesPLoS Pathogens, 2023
Alongshan virus (ALSV), a newly discovered member of unclassified Flaviviridae family, is able to infect humans. ALSV has a multi-segmented genome organization and is evolutionarily distant from canonical mono-segmented flaviviruses.
Hua Chen   +22 more
doaj   +1 more source

Immediate Antiretroviral Therapy Decreases Mortality Among Patients With High CD4 Counts in China: A Nationwide, Retrospective Cohort Study. [PDF]

open access: yes, 2017
BackgroundClinical trials have demonstrated that immediate initiation of antiretroviral therapy (ART) reduces AIDS-related morbidity and mortality. We tested the hypothesis that initiating ART ≤30 days after human immunodeficiency virus (HIV) diagnosis ...
Brookmeyer, Ron   +10 more
core   +1 more source

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