Results 91 to 100 of about 35,778 (326)

Clinical pharmacokinetics of quinine and its relationship with treatment outcomes in children, pregnant women, and elderly patients, with uncomplicated and complicated malaria: a systematic review

Malaria Journal, 2022
Background Standard dosage regimens of quinine formulated for adult patients with uncomplicated and complicated malaria have been applied for clinical uses in children, pregnant women, and elderly.
Teerachat Saeheng, Kesara Na-Bangchang
doaj   +1 more source

Artemisinin-based combination therapy for treating uncomplicated malaria [PDF]

Cochrane Database of Systematic Reviews, 2009
The World Health Organization recommends uncomplicated P. falciparum malaria is treated using Artemisinin-based Combination Therapy (ACT). This review aims to assist the decision making of malaria control programmes by providing an overview of the relative benefits and harms of the available options.To compare the effects of ACTs with other available ...
David, Sinclair, Babalwa, Zani, Sarah, Donegan, Piero, Olliaro, Paul, Garner   +4 more
openaire   +2 more sources

EnzRetro: Enzymatic Retrosynthetic Planning With Site‐Specific Reaction Edits Based on Sequence Generative Architecture

Exploration, EarlyView.
EnzRetro bridges retrosynthesis planning and enzymatic engineering through site‐specific reaction edits. This end‐to‐end framework integrates pathway synthesis and enzyme identification into a unified process, achieving superior accuracy and enabling the efficient reconstruction of diverse biosynthetic pathways.
Yahui Cao, Haoshu Chen, Tao Zhang, Xin Zhao, Bingzhi Li, Xiangrui Zheng   +5 more
wiley   +1 more source

Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and elimination

, 2015
Antimalarial drugs are a powerful tool for malaria control and elimination. Artemisinin-based combination therapies (ACTs) can reduce transmission when widely distributed in a campaign setting.
Eckhoff, Philip, Gerardin, Jaline, Wenger, Edward A.   +2 more
core   +1 more source

Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. [PDF]

, 2017
BackgroundPlasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth ...
Arinaitwe, Emmanuel, Conrad, Melissa, Dorsey, Grant, Greenhouse, Bryan, Kamya, Moses R, Nsobya, Samuel L, Rosenthal, Philip J, Tukwasibwe, Stephen, Tumwebaze, Patrick   +8 more
core   +1 more source

Management of uncomplicated malaria

Continuing Medical Education, 2008
The key issues in the successful management of malaria are early and accurate diagnosis and urgent treatment with effective drugs. Disease presentation is, however, not specific – progression to complicated disease may be rapid in non-immune persons, particularly in young children and pregnant women, and parasite drug resistance significantly ...
Blumberg, Lucille, Frean, John, Barnes, Karen I.   +2 more
openaire   +1 more source

Artificial intelligence for personalized multiple micronutrient supplementation in maternal health

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Maternal undernutrition and micronutrient deficiencies remain pervasive, contributing to adverse pregnancy outcomes and long‐term health risks for mothers and offspring. Multiple micronutrient supplementation (MMS) during pregnancy has demonstrated benefits, including reduced risks of low birth weight, small‐for‐gestational‐age births, and ...
Gabriel Davis Jones, Aris T. Papageorghiou, Hassan Shehata, Hema Divakar, Eline M. Van der Beek, Vyta Senikas, Justin C. Konje, Anne‐Beatrice Kihara, Moshe Hod   +8 more
wiley   +1 more source

Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin. [PDF]

PLoS ONE, 2013
BackgroundPlasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based on sequence homology PfEMP-1 variants have been grouped into three major groups A-
Gwladys I Bertin, Thomas Lavstsen, François Guillonneau, Justin Doritchamou, Christian W Wang, Jakob S Jespersen, Sem Ezimegnon, Nadine Fievet, Maroufou J Alao, Francis Lalya, Achille Massougbodji, Nicaise Tuikue Ndam, Thor G Theander, Philippe Deloron   +13 more
doaj   +1 more source

Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria [PDF]

Cochrane Database of Systematic Reviews, 2019
The World Health Organization (WHO) recommends artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum (P falciparum) malaria. Concerns about artemisinin resistance have led to global initiatives to develop new partner drugs to protect artemisinin derivatives in ACT. Pyronaridine-artesunate is a novel ACT.To evaluate
Pryce, Joseph, Hine, Paul
openaire   +3 more sources

Wild Animal Suffering Is Not Intractable: A Precautionary Approach to Compassionate Intervention

Journal of Applied Philosophy, EarlyView.
ABSTRACT Wild animals suffer due to human activity, yet natural factors contribute far more significantly to their suffering. In light of this, some propose that we have a pro tanto obligation to intervene in ecosystems to improve wild animal welfare.
Tristan Katz
wiley   +1 more source