Results 151 to 160 of about 4,581 (187)

Machine learning, whole-transcriptome and integrative omics analysis reveals key regulatory networks governing human spermatogonial stem cells. [PDF]

Clin Exp Med
Hashemi Karoii D, Osanloo M, Azizi H, Skutella T.   +3 more
europepmc   +1 more source

Reconstitution of spermatogenesis and continuous generation of functional haploid germ cells in mouse testicular organoids. [PDF]

Nat Commun
Wan C, Li Q, Yao Z, Ye Z, Zhao J, Ren S, Xue X, Tang K, Rao Q, Weng Y, Xu H, Wang W, Zhong C, Li X, Yang X, Pan M, Cui M, Ma L, Chen D, Li C, Zheng Z, Zheng Y, Liu Z, Chang G, Miao K, Luo F, Zhao XY.   +26 more
europepmc   +1 more source

Feedback Regulation of the Proliferation of the Undifferentiated Spermatogonia In the Chinese Hamster By the Differentiating Spermatogonia

Cell Proliferation, 1985
AbstractIn the seminiferous epithelium the differentiating spermatogonia proliferate following a very strict synchronous pattern, and undergo the S phase during parts of particular epithelial stages. the undifferentiated spermatogonia do not divide synchronously and display maximum proliferative activity in stages XI‐III.
D G Rooij, Dirk G de Rooij
exaly   +5 more sources

Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population

Developmental Biology, 2008
Nanos gene encodes for zinc-finger protein with putative RNA-binding activity which shows an evolutionary conserved function in germ cell development. In the mouse, three Nanos homologs have been identified: Nanos1, Nanos2 and Nanos3. The Nanos3 ortholog is expressed in both male and female gonads of early embryo and, after birth, it is found only in ...
Rita Marino, Maria Paola Paronetto, Manuela Pellegrini   +2 more
exaly   +6 more sources

Differential Expression of c-kit in Mouse Undifferentiated and Differentiating Type A Spermatogonia [PDF]

Endocrinology, 1999
The proto-oncogene c-kit is encoded at the white-spotting locus and in the mouse mutations at this locus affect the precursor cells of melanocytes, hematopoietic cells, and germ cells. c-kit is expressed in type A spermatogonia, but whether or not c-kit is present both in undifferentiated and differentiating type A spermatogonia or only in the latter ...
Dirk G de Rooij, Ans M M Van Pelt, De Rooij Dirk G   +2 more
exaly   +6 more sources

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ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice

Reproductive Biology, 2023
Spermatogenesis is a continual process that relies on the activities of undifferentiated spermatogonia, which contain spermatogonial stem cells (SSCs) that serve as the basis of spermatogenesis. The gene expression pattern and molecular control of fate decisions of undifferentiated spermatogonia are not well understood.
Qi-En Yang
exaly   +3 more sources

A comparison between the morphology and cell kinetics of gonocytes and adult type undifferentiated spermatogonia in the mouse

Journal of Developmental and Physical Disabilities, 1981
A comparison has been made between gonocytes and adult type undifferentiated spermatogonia in the mouse. The following morphological resemblances were noted: 1.
D G Rooij, Dirk G de Rooij
exaly   +2 more sources

Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest

Cell Stem Cell, 2008
SummaryMammalian spermatogenesis is maintained by stem cell capacity within undifferentiated spermatogonial subpopulation. Here, using a combination of surface markers, we describe a purification method for undifferentiated spermatogonia. Flow cytometric
Keiyo Takubo, Masako Ohmura, Fumio Arai   +2 more
exaly   +2 more sources

The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse [PDF]

BMC Developmental Biology, 2009
AbstractBackgroundLife-long production of spermatozoa depends on spermatogonial stem cells. Spermatogonial stem cells exist among the most primitive population of germ cells – undifferentiated spermatogonia. Transplantation experiments have demonstrated the functional heterogeneity of undifferentiated spermatogonia.
Ke Zheng, Xin Wu, Klaus H Kaestner
exaly   +3 more sources