Results 51 to 60 of about 486 (156)
Does LIN28B gene dysregulation make women more likely to abort?
Reproduction and Fertility, 2021 Background: LIN28B plays an important role in early embryonic development, but its role in villous trophoblast implantation and differentiation remains unknown.
QiaoYao Huang +5 more
doaj +1 more source
Can the Decreased Expression of Human Leukocyte Antigen Class Ⅰ and Ⅱ by Spermatozoa Lead to Recurrent Spontaneous Abortion? [PDF]
, 2020 BACKGROUND & OBJECTIVE: Unexplained recurrent spontaneous abortion (URSA) is defined as an unknown cause of occurrence of three or more clinically detectable pregnancy losses before 20 weeks of gestation, but it occurs presumably as a result of the ...
Andalib, Alireza +5 more
core +1 more source
Journal of International Medical Research, 2020 Objective The present study aimed to evaluate the effects of cluster of differentiation (CD)4 + CD25 + forkhead box p3 (Foxp3) + regulatory T cells (Tregs) on unexplained recurrent spontaneous abortion (URSA) and the associated mechanisms.
Shuang Qin +6 more
doaj +1 more source
HMGB1: a double-edged sword and therapeutic target in the female reproductive system [PDF]
, 2023 HMGB1 that belongs to the High Mobility Group-box superfamily, is a nonhistone chromatin associated transcription factor. It is present in the nucleus of eukaryotes and can be actively secreted or passively released by kinds of cells.
Beili Chen +29 more
core +1 more source
Ecotoxicology and Environmental Safety, 2022 Emerging per- and polyfluoroalkyl substances (PFAS) alternatives are increasingly used in daily life. Although legacy PFAS have been associated with miscarriage in previous studies, it remains unknown whether exposure to emerging and legacy PFAS has any ...
Min Nian +6 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2021 Unexplained recurrent spontaneous abortion (URSA) is one of the most intractable clinical challenges in reproduction. As a specific type of endogenous non-coding RNA, circular RNAs (circRNAs) have great pre-clinical diagnostic and therapeutic values in ...
Minyue Tang +10 more
doaj +1 more source
Alteration of Th17 and Treg cells in patients with unexplained recurrent spontaneous abortion before and after lymphocyte immunization therapy [PDF]
, 2014 BACKGROUND: Several types of T cells have been associated with the pathogenesis of unexplained recurrent spontaneous abortion (URSA), including Th1/Th2/Th17/Tregs cell.
Bo Xu +7 more
core +2 more sources
Frontiers in Genetics, 2022 The diagnosis and treatment of unexplained recurrent spontaneous abortion (URSA) are subject to debate, because the exact underlying mechanisms remain unclear. To address this issue, we elucidated the expression profiles of dysregulated circRNAs, miRNAs,
Xiaohua Liu +13 more
doaj +1 more source
Recent Advances in Immunotherapeutic Approaches for Recurrent Reproductive Failure [PDF]
, 2022 Human reproduction is an insufficient process, disturbed by various factors, such as immunologic aberrations of mother. Immunologic abnormalities, including cellular and humoral immunity imbalance, cause dysregulated immune responses against embryo ...
Abdolmohammadi-Vahid, Samaneh +4 more
core +2 more sources
The effects of DICER1 and DROSHA polymorphisms on susceptibility to recurrent spontaneous abortion
Journal of Clinical Laboratory Analysis, Volume 34, Issue 3, March 2020., 2020 Abstract Background Recurrent spontaneous abortion (RSA) is a serious problem in pregnancy. The exact etiology of RSA is unknown in more than 50% of all the patients. However, genetic variations are known as susceptibility factors for idiopathic RSA. Considering the role of miRNA biosynthesis machinery in the miRNA production and effect of miRNAs on ...
Marzieh Ghasemi +6 more
wiley +1 more source