Analysis of Risk Factors Affecting Cumulative Live Birth in Couples With Unexplained Infertility Undergoing IVF/ICSI. [PDF]
Reprod Med BiolOur study demonstrated a striking prevalence of unexplained infertility (UI) at 8.8% within the study cohort. Notably, patients undergoing a complete IVF/ICSI cycle achieved a remarkable cumulative live birth rate (CLBR) of 62.2%, highlighting the clinical efficacy of assisted reproductive technologies in this population.
Liu R +6 more
europepmc +2 more sources
AQP3 Influences Unexplained Recurrent Abortion by Regulating Trophoblast Cell Migration and Invasion via the METTL14/IGF2BP1/AQP3/PI3K/AKT Pathway. [PDF]
J Cell Mol MedABSTRACT Reduced trophoblast migration and invasion contribute to unexplained recurrent spontaneous abortion (URSA). Aquaporin 3 (AQP3) plays a crucial role in facilitating trophoblast migration and invasion during early pregnancy through fetal‐maternal crosstalk.
Nong Y +8 more
europepmc +2 more sources
Evaluation of the Effects of 1,25VitD3 on Inflammatory Responses and IL-25 Expression
Frontiers in Genetics, 2021 VitD3 may contribute to a successful pregnancy through modulation of immune responses, so VitD3 deficiency may have a role in the immunopathogenesis of unexplained recurrent spontaneous abortion (URSA). However, the mechanisms of immunomodulatory actions
Nana Li +10 more
doaj +1 more source
Clinical Effect of Yunkang Granule Combined with Low Dose Aspirin in the Treatment of Unexplained Recurrent Abortion and Its Influence on Pregnancy Outcome [PDF]
, 2023 Purpose: To study the clinical effect of Yunkang Granule combined with low dose aspirin in the treatment of unexplained recurrent abortion (URSA) and its impact on pregnancy outcome.
Zhang, Yanchun
core +2 more sources
Effect of prednisone on IL-17 secretion in maternal-fetal immune rejection cell model, and on IL-23/IL-17 inflammation axis [PDF]
, 2021 Purpose: To investigate the influence of prednisone on secretion of IL-17 in maternal-fetal immune rejection cell model, and on tIL-23/IL-17 inflammation axis. Methods: Four groups of Kunming mice were used.
Li, Xiaoyan, Pu, Yuhua
core +2 more sources
Romanian Journal of Laboratory Medicine, 2022 Background: To investigate the associations of serum vitamin D and Fok I polymorphism of its receptor (VDR) with unexplained recurrent spontaneous abortion (URSA).
Liu Hebin +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Recurrent spontaneous abortion (RSA) is a common complication of pregnancy that affects the physical and mental health of pregnant women, and approximately 50% of the mechanisms are unclear. Our previous studies have found that high mobility group box 1 (
Damin Zhu +53 more
doaj +1 more source
Open Life Sciences, 2022 Unexplained recurrent spontaneous abortion (URSA) is a major concern in reproductive medicine. Neutrophil cytosolic factor 1 (NCF1) polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases.
Du Mengxuan +9 more
doaj +1 more source
Research progress of immune balance and genetic polymorphism in unexplained recurrent abortion
Exploration of Immunology, 2023 The etiology of recurrent spontaneous abortion (RSA) is extremely complex, as there are 40–50% of patients with unexplained miscarriages, known as unexplained RSA (URSA).
Yafei Kang +8 more
doaj +1 more source
Frontiers in Endocrinology, 2022 BackgroundHigh mobility group box protein 1 (HMGB1) is considered as a kind of sterile inflammatory mediators, which is an overexpression in patients with unexplained recurrent spontaneous abortion (URSA).
Xiaofeng Xu +39 more
doaj +1 more source