Results 21 to 30 of about 486 (156)

Deciphering N7-methylguanosine-driven immune dysregulation in unexplained recurrent spontaneous abortion based on transcriptome data and experimental validation [PDF]

European Journal of Medical Research
Background Unexplained recurrent spontaneous abortion (URSA) poses significant clinical challenges, with immune dysregulation at the maternal–fetal interface implicated in 80% of cases.
Qing Guo, Shimeng Wang, Sujie Song, Xiaoxuan Zhao   +3 more
doaj   +2 more sources

Daphnetin alleviates unexplained recurrent spontaneous abortion by regulating the NR4A1/BACH2 axis in mice [PDF]

Biological Research
Background Daphnetin has demonstrated various pharmacological activities. The current study evaluated the potential of daphnetin in alleviating unexplained recurrent spontaneous abortion (URSA) and explored underlying mechanisms.
Zhiqin Zhang, Jun Tan, Xingwu Wu, Xin Li, Peipei Liu, Liyun Cao, Shenggen Long   +6 more
doaj   +2 more sources

Linolamide in apoptotic bodies: a key factor in mesenchymal stem cell immunotherapy for two abortion models [PDF]

Stem Cell Research & Therapy
Background Unexplained recurrent spontaneous abortion (URSA) is a distressing pregnancy disorder with no effective medical intervention. As a potential treatment for URSA, human umbilical cord mesenchymal stem cells (hucMSCs) undergo apoptosis and ...
Zhan Shi, Xiaowen Lu, Haiyi Fei, Xiu Liu, Shiqian Xu, Yuhan Lin, Ling Fang, Lingling Jiang, Songying Zhang   +8 more
doaj   +2 more sources

Decidual stromal cells-derived exosomes incured insufficient migration and invasion of trophoblast because of abnormal ubiquitination and degradation of Snail mediated by miR-92b-3p/USP28 [PDF]

BMC Biology
Background Recent findings have demonstrated that inadequate trophoblast migration and invasion are often responsible for the unsuccessful communication between the mother and fetus, contributing to URSA (unexplained recurrent spontaneous abortion ...
Miao Xiong, Ziqiu He, Liping Wen, Aimin Zhao   +3 more
doaj   +2 more sources

Silencing circRNA-ZFAND6 induces trophoblast apoptosis by activating the mitochondrial pathway through the miR-575/SOD2 axis in unexplained recurrent spontaneous abortion [PDF]

BMC Women's Health
Background Unexplained recurrent spontaneous abortion (URSA) is a major problem in the field of human reproductive health. At present, several circRNAs have been reported to be differentially expressed and play an important biological function in ...
Wenting Wang, Linxiang Huang, Juan Lv, Zhijing Miao, Shuping Jin, Shan Li, Qing Cheng   +6 more
doaj   +2 more sources

Metabolomics and proteomics analyses reveal the role of the glycerophospholipid metabolism pathway in unexplained recurrent spontaneous abortion [PDF]

PeerJ
Background Unexplained recurrent spontaneous abortion (URSA) is a complex pregnancy complication with a high miscarriage rate. Incomprehensive understanding of the molecular mechanism in URSA also leads to a lack of effective treatment methods.
Yihong Chen, Xiumei Zhao, Bei Gan, Leiyi Jin, Juanbing Wei, Jianying Yan   +5 more
doaj   +3 more sources

Association between per- and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion: A case-control study in China

Ecotoxicology and Environmental Safety
Although prior studies have identified that per- and polyfluoroalkyl substances (PFASs) were associated with adverse pregnancy outcomes, the potential influence of PFASs exposure on unexplained recurrent spontaneous abortion (URSA) remains uncertain. Our
Qianxi Cheng, Chunxian Lv, Yawei Li, Haocan Song, Shuyao Li, Dandan Li, Yingying Han, Feng Zhao, Qiang Lin   +8 more
doaj   +3 more sources

Gene Expression Analysis of VEGF and Its Receptors and Assessment of Its Serum Level in Unexplained Recurrent Spontaneous Abortion [PDF]

Cell Journal, 2015
Objective: Unexplained recurrent spontaneous abortion (URSA) is one of the main complications of pregnancy which is usually defined as three or more consecutive pregnancy losses before the 20th week of gestation without a known cause.
Elham Amirchaghmaghi, Abbas Rezaei, Ashraf Moini, Mohammad Ali Roghaei, Maryam Hafezi, Reza Aflatoonian   +5 more
doaj   +2 more sources

Decidual stromal cells-derived exosomes incurred insufficient migration and invasion of trophoblast by disturbing of β-TrCP-mediated snail ubiquitination and degradation in unexplained recurrent spontaneous abortion [PDF]

European Journal of Medical Research
Background Exosomes released from decidual stromal cells (DSC-exos) play a crucial role in facilitating the epithelial–mesenchymal transition (EMT) of trophoblasts and insufficient trophoblasts EMT are associated with URSA (unexplained recurrent ...
Miao Xiong, Qiaohong Wang, Xiaoxin Zhang, Liping Wen, Aimin Zhao   +4 more
doaj   +2 more sources

Microbiota in Uterine Cavity of Unexplained Recurrent Spontaneous Abortion (URSA) Patients in Early Pregnancy [PDF]

SSRN Electronic Journal, 2021
Abstract Purpose The purpose of this study is to determine the uterine cavity microbial composition in unexplained recurrent spontaneous abortion (URSA) patients and to understand the correlation between URSA and uterine cavity microbiota. Methods Using the double-lumen embryo transfer tubes to collect uterine cavity fluid samples from pregnant
Shiyu Bai, Shuai Fu, Liqiong Zhu, Manqi Chen, Bingqian Huang, Lihao Hu, Hui Chen, Jianping Zhang   +7 more
openaire   +1 more source