Results 101 to 110 of about 1,004,483 (288)
eLife, 2016 Two mechanisms ensure that the mRNA encoding Hac1 protein, a transcription factor involved in the unfolded protein response, is only translated when it is needed.
David J Young, Nicholas R Guydosh
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Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]
, 2016 Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene +12 more
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Unfolded protein response in hepatitis C virus infection
Frontiers in Microbiology, 2014 Hepatitis C virus (HCV) is a single-stranded, positive-sense RNA virus of clinical importance. The virus establishes a chronic infection and can progress from chronic hepatitis, steatosis to fibrosis, cirrhosis and hepatocellular carcinoma.
Shiu-Wan eChan
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Evolution of the unfolded protein response
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013 The unfolded protein response (UPR) is a network of signaling pathways that responds to stress in the endoplasmic reticulum (ER). The general output of the UPR is to upregulate genes involved in ER function, thus restoring and/or increasing the capacity of the ER to fold and process proteins. In parallel, many organisms have mechanisms for limiting the
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The role of the unfolded protein response in myelination
Neural Regeneration Research, 2016 The production, transport and integration of myelin components into the membrane during development is a highly coordinated and regulated process that relies heavily on the endoplasmic reticulum (ER), a sub-cellular organelle that is the principal site of membrane assembly.
FitzGerald, Una +2 more
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Druggable sensors of the unfolded protein response [PDF]
Nature Chemical Biology, 2014 The inability of cells to properly fold, modify and assemble secretory and transmembrane proteins leads to accumulation of misfolded proteins in the endoplasmic reticulum (ER). Under these conditions of 'ER stress', cell survival depends on homeostatic benefits from an intracellular signaling pathway called the unfolded protein response (UPR).
Maly, Dustin J, Papa, Feroz R
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The unfolded protein response in hereditary haemochromatosis [PDF]
Journal of Cellular and Molecular Medicine, 2007 AbstractTo cope with the accumulation of unfolded or misfolded proteins the endoplasmic reticulum (ER) has evolved specific signalling pathways collectively called the unfolded protein response (UPR). Elucidation of the mechanisms governing ER stress signallinghas linked this response to the regulation of diverse physiologic processes as well as to the
M. de Sousa, S. F. de Almeida
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Regulation of the unfolded protein response by microRNAs
Cellular and Molecular Biology Letters, 2013 AbstractThe unfolded protein response (UPR) is an adaptive response to the stress that is caused by an accumulation of misfolded proteins in the lumen of the endoplasmic reticulum (ER). It is an important component of cellular homeostasis. During ER stress, the UPR increases the protein-folding capacity of the endoplasmic reticulum to relieve the ...
Kinga Kochan +6 more
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Putting the brakes on the unfolded protein response [PDF]
Journal of Cell Biology, 2011 The unfolded protein response is an ancient cellular pathway for rapidly responding to endoplasmic reticulum stress. Two studies in this issue (Rubio et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201007077 and Chawla et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201008071) provide insight into how the unfolded protein response is tamped down to restore ...
Robert H. Silverman, Frank Sicheri
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Mitochondrial molecular chaperones [PDF]
, 1994 After synthesis in the cytosol, most mitochondrial proteins must traverse mitochondrial membranes to reach their functional location. During this process, proteins become unfolded and then refold to attain their native conformation after crossing the ...
Atencio +32 more
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