Results 121 to 130 of about 1,004,483 (288)

How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]

, 2017
Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias, Mukherjee, Shaeri, Schlaermann, Philipp   +2 more
core   +2 more sources

A mechanism of ineffective erythropoiesis in β-thalassemia/Hb E disease

Haematologica, 2010
Background Cells respond to stress stimuli through a number of response pathways, of which one of the most important and well characterized is the unfolded protein response.
Pathrapol Lithanatudom, Amporn Leecharoenkiat, Tirawat Wannatung, Saovaros Svasti, Suthat Fucharoen, Duncan R. Smith   +5 more
doaj   +1 more source

Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases

Frontiers in Immunology, 2020
The endoplasmic reticulum (ER) is the major organelle in the cell for protein folding and plays an important role in cellular functions. The unfolded protein response (UPR) is activated in response to misfolded or unfolded protein accumulation in the ER.
Ji-Ae Choi, Ji-Ae Choi, Ji-Ae Choi, Chang-Hwa Song, Chang-Hwa Song, Chang-Hwa Song   +5 more
doaj   +1 more source

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal. [PDF]

, 2020
Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in protein synthesis impair stem cell function, but the mechanisms by which this occurs are largely unknown.
Chua, Bernadette A, Dillingham, Christopher H, Hatters, Danny M, Hidalgo San Jose, Lorena, Hong, Yuning, Kruta, Miriama, Signer, Robert AJ, Sunshine, Mary Jean   +7 more
core   +1 more source

Signaling the mitochondrial unfolded protein response

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013
Mitochondria are compartmentalized organelles essential for numerous cellular functions including ATP generation, iron-sulfur cluster biogenesis, nucleotide and amino acid metabolism as well as apoptosis. To promote biogenesis and proper function, mitochondria have a dedicated repertoire of molecular chaperones to facilitate protein folding and quality
Amrita M. Nargund, Mark W. Pellegrino, Cole M. Haynes   +2 more
openaire   +3 more sources

Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance

International Journal of Molecular Sciences, 2019
The unfolded protein response (UPR) is a stress response activated by the accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its uncontrolled activation is mechanistically responsible for several human ...
L. Sisinni, M. Pietrafesa, S. Lepore, F. Maddalena, V. Condelli, F. Esposito, M. Landriscina   +6 more
semanticscholar   +1 more source

The unfolded protein response in Alzheimer’s disease

Seminars in Immunopathology, 2013
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by synaptic dysfunction and accumulation of amyloid-beta (Aβ) peptide, which are responsible for the progressive loss of memory. The mechanisms involved in neuron dysfunction in AD remain poorly understood.
Cornejo, Víctor Hugo, Hetz Flores, Claudio   +1 more
openaire   +7 more sources

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

Frontiers in Pharmacology, 2019
Obesity has been implicated as a risk factor for insulin resistance and cardiovascular diseases (CVDs). Although the association between obesity and CVD is a well-established phenomenon, the precise mechanisms remain incompletely understood. This has led
O. Amen, S. Sarker, R. Ghildyal, A. Arya
semanticscholar   +1 more source

Yeast Bax inhibitor, Bxi1p, is an ER-localized protein that links the unfolded protein response and programmed cell death in Saccharomyces cerevisiae.

PLoS ONE, 2011
Bax inhibitor-1 (BI-1) is an anti-apoptotic gene whose expression is upregulated in a wide range of human cancers. Studies in both mammalian and plant cells suggest that the BI-1 protein resides in the endoplasmic reticulum and is involved in the ...
James Cebulski, Joshua Malouin, Nathan Pinches, Vincent Cascio, Nicanor Austriaco   +4 more
doaj   +1 more source

Cardioprotection by the mitochondrial unfolded protein response (UPRmt) requires ATF5.

American Journal of Physiology. Heart and Circulatory Physiology, 2019
The mitochondrial unfolded protein response (UPRmt) is a cytoprotective signaling pathway triggered by mitochondrial dysfunction. UPRmt activation up-regulates chaperones, proteases, antioxidants, and glycolysis at the gene level to restore proteostasis ...
Yves T. Wang, Y. Lim, M. Mccall, Kai Huang, Cole M. Haynes, K. Nehrke, P. Brookes   +6 more
semanticscholar   +1 more source