Results 131 to 140 of about 1,004,483 (288)

Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER

Cell Reports
Summary: Despite the consensus that accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen, i.e. ER stress, activates the unfolded protein response (UPR), studies under physiological and pathophysiological conditions suggest that ER ...
Fenfen Xu, Likun Wang
doaj   +1 more source

A functional link between the co-translational protein translocation pathway and the UPR

eLife, 2015
Upon endoplasmic reticulum (ER) stress, the transmembrane endoribonuclease Ire1α performs mRNA cleavage reactions to increase the ER folding capacity. It is unclear how the low abundant Ire1α efficiently finds and cleaves the majority of mRNAs at the ER ...
Rachel Plumb, Zai-Rong Zhang, Suhila Appathurai, Malaiyalam Mariappan   +3 more
doaj   +1 more source

Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development

International Journal of Molecular Sciences, 2019
Mammalian oocytes and early embryos derived from in vitro production are highly susceptible to a variety of cellular stresses. During oocyte maturation and preimplantation embryo development, functional proteins must be folded properly in the endoplasmic
T.-A. Lin, Jae Eun Lee, J. Kang, H. Shin, Ju Bin Lee, D. Jin   +5 more
semanticscholar   +1 more source

Unconventional Splicing of HAC1/ERN4 mRNA Required for the Unfolded Protein Response [PDF]

, 1998
Tetsushi Kawahara, Hideki Yanagi, Takashi Yura, Kazutoshi Mori   +3 more
openalex   +1 more source

The unfolded protein response in neurodegenerative disorders – therapeutic modulation of the PERK pathway

The FEBS Journal, 2019
The unfolded protein response (UPR) is a highly conserved protein quality control mechanism, activated in response to Endoplasmic Reticulum (ER) stress.
Daniel T. Hughes, G. Mallucci
semanticscholar   +1 more source

Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process

International Journal of COPD, 2011
Patrick Geraghty, Alison Wallace, Jeanine M D'ArmientoDepartment of Medicine, Divisions of Molecular and Pulmonary Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USAPurpose: Cigarette smoke is the major risk ...
Geraghty P, Wallace A, D'Armiento J   +2 more
doaj  

Finding undetected protein associations in cell signaling by belief propagation

, 2011
External information propagates in the cell mainly through signaling cascades and transcriptional activation, allowing it to react to a wide spectrum of environmental changes.
A. Braunstein, A. Dagkessamanskaia, Aronova, Bashor, Bayati, Benayoun, Burkholder, C. Borgs, Dickson, Guldener, Huang, J. Chayes, J.- M. Francois, Jenness, King, Kuranda, Locasale, M. Bailly-Bechet, Miyake, Nickell, Pei, R. Zecchina, Roberts, Scott, Soufi, Spode, Thattai, Travers, Xenarios, Yosef, Zheng   +30 more
core   +3 more sources

Reshaping endoplasmic reticulum quality control through the unfolded protein response.

Molecules and Cells, 2022
R. Wiseman, Jaleh S. Mesgarzadeh, L. Hendershot   +2 more
semanticscholar   +1 more source

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

International Journal of Molecular Sciences, 2019
Cancer constitutes a grave problem nowadays in view of the fact that it has become one of the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer cells metabolism as tumor microenvironment is affected by oxidative stress ...
Natalia Siwecka, W. Rozpędek, D. Pytel, Adam Wawrzynkiewicz, A. Dziki, Ł. Dziki, J. A. Diehl, I. Majsterek   +7 more
semanticscholar   +1 more source

The novel MMS‐inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway [PDF]

, 2000
Theo van Laar, Theo Schouten, Esther M. Hoogervorst, Marga van Eck, Alex J. van der Eb, Carrol Terleth   +5 more
openalex   +1 more source