Results 141 to 150 of about 80,560 (274)
The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots
Advanced Science, EarlyView.DNA is thought to determine shape, behavior, and lifespan, with developmental plasticity reserved for stem cells, embryos, and species like amphibia. How much morphogenetic plasticity do adult somatic human cells exhibit? Anthrobots are a self‐organizing, motile synthetic living construct made of genetically normal human epithelial cells.
Gizem Gumuskaya +6 more
wiley +1 more source
Advanced Science, EarlyView.Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang +11 more
wiley +1 more source
Advanced Science, EarlyView.ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma +18 more
wiley +1 more source
Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer
Molecular Oncology, 2019 Estrogens have been shown to elicit anticancer effects against estrogen receptor α (ER)‐positive breast cancer. We sought to determine the mechanism underlying the therapeutic response.
Sarah R. Hosford +8 more
doaj +1 more source
Endoplasmic Reticulum Oxidoreductin 1-Lβ (ERO1-Lβ), a Human Gene Induced in the Course of the Unfolded Protein Response [PDF]
, 2000 Massimiliano Pagani +7 more
openalex +1 more source
Advanced Science, EarlyView.The electron transfer flux in CPR‐P450 catalytic system is systematically engineered through: i) enhancing electron transfer rate by redesigning the putative electron transfer pathway of CPR; ii) improving electron‐receiving rate by evolving the heme domain of tryptophan‐5‐hydroxylase (T5H); iii) enlarging electron supply by fine‐tuning NADPH synthesis.
Wenzhao Xu +4 more
wiley +1 more source
The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast [PDF]
, 2000 Martin Schröder +2 more
openalex +1 more source
Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA
Advanced Science, EarlyView.Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin +9 more
wiley +1 more source
Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation [PDF]
, 2000 Kevin Travers +5 more
openalex +1 more source
A Mass Spectrometry Approach Reveals Fatty Acid Isomerism in Tomato Cold Tolerance
Advanced Science, EarlyView.An enhanced mass spectrometry approach reveals fatty acids (FAs) and FA isomers that are critical for tomato cold tolerance. Applying specific FA isomers can partially rescue cold sensitivity in tomato mutant plants, highlighting the importance of FA isomers in plant cold stress adaptation.
Leelyn Chong +7 more
wiley +1 more source