Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer
Molecular Oncology, 2019 Estrogens have been shown to elicit anticancer effects against estrogen receptor α (ER)‐positive breast cancer. We sought to determine the mechanism underlying the therapeutic response.
Sarah R. Hosford +8 more
doaj +1 more source
The Unfolded Protein Response Regulates Multiple Aspects of Secretory and Membrane Protein Biogenesis and Endoplasmic Reticulum Quality Control [PDF]
, 2000 Davis Ng, Eric D. Spear, Peter Walter
openalex +1 more source
E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes. [PDF]
, 2019 Objective: Since the introduction in 2004, global usage of e-cigarettes (ECs) has risen exponentially. However, the risks of ECs on oral health are uncertain.
Chen, Wei +9 more
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The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response [PDF]
, 2000 Witoon Tirasophon +4 more
openalex +1 more source
Endoplasmic Reticulum Oxidoreductin 1-Lβ (ERO1-Lβ), a Human Gene Induced in the Course of the Unfolded Protein Response [PDF]
, 2000 Massimiliano Pagani +7 more
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Protein folding tames chaos [PDF]
, 2013 Protein folding produces characteristic and functional three-dimensional structures from unfolded polypeptides or disordered coils. The emergence of extraordinary complexity in the protein folding process poses astonishing challenges to theoretical ...
Wei, Guo-Wei, Xia, Kelin
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The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast [PDF]
, 2000 Martin Schröder +2 more
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Proteostasis collapse is a driver of cell aging and death. [PDF]
, 2019 What molecular processes drive cell aging and death? Here, we model how proteostasis-i.e., the folding, chaperoning, and maintenance of protein function-collapses with age from slowed translation and cumulative oxidative damage.
de Graff, Adam MR +2 more
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Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α [PDF]
, 2001 Isabel Novoa +3 more
openalex +1 more source
The PERK Pathway Regulates Yap Transcription during Unfolded Protein Response [PDF]
, 2015 Hippo信号通路是近年来在果蝇体内发现的一条进化上高度保守的信号转导通路，该通路对控制组织器官大小以及细胞增殖、凋亡有着重要的调节作用。Yap是Hippo信号通路主要的效应分子，Hippo通路的缺失造成Yap的激活，细胞增殖增加，凋亡减少，从而导致器官增大以及肿瘤发生。Hippo通路通过一系列磷酸化级联反应来调控Yap的磷酸化、降解和细胞核定位，从而实现抑制Yap的促癌功能。探索Yap的调控机制有着重大意义，在本项目研究中我们发现内质网应激能够在转录水平调控Yap ...
范鑫
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