Results 161 to 170 of about 1,143,124 (339)
Advanced Science, EarlyView.A DNA‐functionalized biohybrid hydrogel is developed by integrating Cu‐mediated nucleic acid microflowers into a thermoresponsive matrix, enabling electrothermally triggered, on‐demand payload release. The platform offers spatiotemporally controllable therapeutic delivery with promising applications in precision oncology, neural regulation, and chronic
Mengqiu Sun +8 more
wiley +1 more source
Analysis of genes controlling notochord development in zebrafish.
, 2006 The notochord is a vital and defining organ in vertebrates. Mutagenesis screening in zebrafish identified seven 'dwarf mutants that lack notochord development grumpy, sleepy, bashful, dopey, happy, sneezy and doc.
Thomas, K.A.
core
, 2019 INTRODUCTION Rhinovirus (RV) infection is a major cause of cystic fibrosis (CF) lung morbidity with limited therapeutic options. Various diseases involving chronic inflammatory response and infection are associated with endoplasmic reticulum (ER ...
Schögler, Aline +7 more
core +1 more source
A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
Advanced Science, EarlyView.A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
Homeostasis in the Unfolded Protein Response [PDF]
, 2012 The endoplasmic reticulum (ER) is the compartment in eukaryotic cells in which secreted and membrane-spanning proteins are folded, modified and assembled.
Pincus, David
core
Schematic overview of the unfolded protein response (UPR) and integrated stress response (ISR).
, 2015 Schematic overview of the unfolded protein response (UPR) and integrated stress response (ISR).
Lucy E. Dalton (756195) +7 more
core +1 more source
Advanced Science, EarlyView.This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang +10 more
wiley +1 more source
The unfolded protein response signaling pathways in molluscs
Invertebrate Survival Journal, 2018 Unfolded protein response (UPR) as collective signal transduction pathways is essential for surviving the endoplasmic reticulum (ER) stress in vertebrates and invertebrates.
Y Huang, J Sun, L Wang, L Song
doaj
Lipid-dependent regulation of the unfolded protein response.
, 2015 Protein folding homeostasis in the lumen of the endoplasmic reticulum is defended by signal transduction pathways that are activated by an imbalance between unfolded proteins and chaperones (so called ER stress).
Ron, David, Volmer, Romain
core +1 more source
Advanced Science, EarlyView.Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li +8 more
wiley +1 more source