Results 171 to 180 of about 162,922 (305)

When Biology Meets Medicine: A Perspective on Foundation Models

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu, Yuxing Wang, Limin Zou, Jing Huang   +3 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Activation of unfolded protein response pathways promotes keratinocyte differentiation and ameliorates psoriasis phenotypes. [PDF]

Cell Stress Chaperones
Zhang Z, Tan M, Liu X, Wang W, Chen X, Peng C, Zhao S, Wu L.   +7 more
europepmc   +1 more source

Smart Bioinspired Material‐Based Actuators: Current Challenges and Prospects

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This work gathers, in a review style, an extensive and comprehensive literature overview on the development of autonomous actuators based on synthetic materials, bringing together valuable knowledge from several studies. Furthermore, the article identifies the fundamental principles of actuation mechanisms and defines key parameters to address the size
Alejandro Palacios, Léon Chiriatti, Simon Poppinga, Thomas Speck, Vincent Le Houérou   +4 more
wiley   +1 more source

bZIP factors of the Unfolded Protein Response interact with PIF4 to promote thermomorphogenesis. [PDF]

Nat Commun
Zhang D, Xu H, Chua NH.
europepmc   +1 more source

MusicSwarm: Biologically Inspired Intelligence for Music Composition

Advanced Intelligent Systems, EarlyView.
Biologically inspired swarms of frozen foundation models self‐organize to compose complex music without fine‐tuning. By coordinating through stigmergic signals, decentralized agents dynamically evolve specialized roles and adapt to solve complex tasks.
Markus J. Buehler
wiley   +1 more source

The Unfolded Protein Response in Sarcomas: From Proteostasis to Therapy Resistance. [PDF]

Cancers (Basel)
Ilieva E, Avnet S, Baldini N, Cortini M.
europepmc   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

Bursting the unfolded protein response accelerates axonal regeneration

Neural Regeneration Research, 2016
Maritza Oñate, Felipe A Court, Claudio Hetz   +2 more
doaj   +1 more source

The Unfolded Protein Response-Novel Mechanisms, Challenges, and Key Considerations for Therapeutic Intervention. [PDF]

Cancers (Basel)
Mai PMQ, Truong TA, Samala SK, Lakshmisha BM, Biswal P, Koushki K, Mallepaddi PC, Vijay G, Krishnan S.   +8 more
europepmc   +1 more source