Results 191 to 200 of about 162,922 (305)

Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications. [PDF]

FASEB J
Dai E, Sun D, Zhao Y, Zhang M, Wu Y, Ding J.   +5 more
europepmc   +1 more source

Mfn2 modulates the unfolded protein response [PDF]

Cell Cycle, 2014
Juan Pablo, Muñoz, Antonio, Zorzano
openaire   +2 more sources

Bacterial Pigments as Potential Antitumor Agents Against Gastrointestinal Cancers: A Comprehensive Systematic Review

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara, Ricardo F. S. Pereira, Carla C. C. R. de Carvalho, Jose Prados, Consolación Melguizo, Raul Ortiz   +5 more
wiley   +1 more source

Defective mitochondrial unfolded protein response in cancer acts as a lifeline for tumor growth and survival. [PDF]

Cell Stress Chaperones
Sharma U, Vishwas V, Kumar RR, Agarwal N, Shree A, Gorain JK, Sasi A, Sharawat SK, Singh A, Palanichamy JK, Bakhshi S.   +10 more
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Comprehensive analysis of mitochondrial unfolded protein response related genes for prognosis and therapeutic response in pancreatic cancer. [PDF]

Front Immunol
Li C, Lu C, Ma Z, Zhao T, Xiao M, Xu Z, Sun Z, Wu Q, Wang L, Zhao L.   +9 more
europepmc   +1 more source

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source

The Interplay Between Ca²⁺ Homeostasis, Endoplasmic Reticulum Stress, and the Unfolded Protein Response in Human Diseases. [PDF]

Cells
Ranzato E, Martinotti S.
europepmc   +1 more source

Harnessing Cellular Feeling: Epigenetic to Mechanical Memory as a Framework for Stem Cell Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stem cell‐based therapies hold transformative potential for regenerative medicine, yet their progress is constrained by persistent variability in manufacturing and clinical performance. Conventional frameworks such as Quality by Design (QbD), though effective for drugs and biologics, struggle to accommodate the dynamic nature of living cell ...
Mee‐Hae Kim, Masahiro Kino‐oka
wiley   +1 more source

The unfolded protein response in progeria arteries originates from non-endothelial cell types. [PDF]

Life Sci Alliance
Silva RA, Sarigol F, Karagöz GE, Osmanagic-Myers S, Foisner R.   +4 more
europepmc   +1 more source