Results 191 to 200 of about 80,560 (274)

Extension of lipid-linked oligosaccharides is a high-priority aspect of the unfolded protein response: endoplasmic reticulum stress in Type I congenital disorder of glycosylation fibroblasts [PDF]

, 2002
J. Shang, Christian Körner, Hudson H. Freeze, Mark A. Lehrman   +3 more
openalex   +1 more source

Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition

Advanced Science, EarlyView.
Phytophthora capsici effector PcRD18 targets tomato GSNOR to disrupt NO homeostasis, promoting S‐nitrosylation of immune proteins like RBOHD. This suppresses ROS bursts and promotes pathogen infection. Mutation of the PcRD18‐binding sites of GSNOR avoids pathogen manipulation and offers a strategy to enhance crop resistance. Abstract Nitric oxide (NO),
Tingting Li, Jing Kang, Haizhu Zhang, Lina Wang, Minghui Lu, Lin Cai, Jianming Li, Matthieu H. A. J. Joosten, Yu Du   +8 more
wiley   +1 more source

Rapid Activation of Glycogen Phosphorylase by the Endoplasmic Reticulum Unfolded Protein Response [PDF]

, 2002
Arvind Gill, Ningguo Gao, Mark A. Lehrman   +2 more
openalex   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

The unfolded protein response is activated in Pelizaeus–Merzbacher disease [PDF]

, 2002
Alexander Gow, Cherie M. Southwood, Jim Garbern, Wei Jiang   +3 more
openalex   +1 more source

Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy

Advanced Science, EarlyView.
Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley   +1 more source

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response [PDF]

, 2003
Ann–Hwee Lee, Neal N. Iwakoshi, Laurie H. Glimcher   +2 more
openalex   +1 more source

Arginine Metabolic Disruption Impairs Hair Regeneration via ROS‐Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia

Advanced Science, EarlyView.
Arginine deficiency accelerates androgenetic alopecia. Serum metabolome shows reduced circulating arginine, while local metabolic disruption depletes follicular reserves, triggering reactive oxygen species (ROS) accumulation and mTOR suppression that induce hair miniaturization.
Shixin Duan, Guo Li, Yanji Chu, Junbo Zhang, Li Yang, Yujin Zhang, Fangfen Liu, Jiayun Li, Mengting Chen, Ben Wang, Zhixiang Zhao, Wei Shi, Yiya Zhang, Guangtong Deng, Xinwei Kuang, Hongfu Xie, Yufan Cheng, Zhili Deng, Ji Li, Yan Tang   +19 more
wiley   +1 more source

Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER

Cell Reports
Summary: Despite the consensus that accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen, i.e. ER stress, activates the unfolded protein response (UPR), studies under physiological and pathophysiological conditions suggest that ER ...
Fenfen Xu, Likun Wang
doaj  

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

, 2001
Donalyn Scheuner, Benbo Song, Edward L. McEwen, Chuan Liu, D. Ross Laybutt, Patrick J. Gillespie, Thomas L. Saunders, Susan Bonner‐Weir, Randal J. Kaufman   +8 more
openalex   +1 more source