Results 261 to 270 of about 167,289 (308)

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

Clinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic, Deanne Nixie R. Miao, Britt I. Drögemöller, Alain Dabdoub, Julia M. Abitbol   +4 more
wiley   +1 more source

Transcriptomic Analysis Uncovers an Unfolded Protein Response in ADNP Syndrome. [PDF]

Mol Cell Biol
Bieluszewska A, Wulfridge P, Fang KC, Hong Y, Sawada T, Erwin J, Song H, Ming GL, Sarma K.   +8 more
europepmc   +1 more source

Metal‐Directed Self‐Assembly in a Beta‐Sheet Miniprotein Scaffold

European Journal of Inorganic Chemistry, EarlyView.
A rationally engineered miniprotein, V14C, which is based on the beta β‐sheet Foldon domain, self‐assembles via a metal‐binding site to form well‐defined oligomers in the presence of Zn2+, Hg2+, and Cd2+. This modular design expands the toolbox for creating custom metalloproteins, enabling studies of metal–protein interactions for biochemical functions
Chandan Muni Reddy, Marcos R. Conde González, Jürgen H. Gross, Franziska Thomas   +3 more
wiley   +1 more source

Impact of ER stress and the unfolded protein response on Fabry disease. [PDF]

EBioMedicine
Lenders M, Rudolph E, Brand E.
europepmc   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Identification of Mitochondrial Unfolded Protein Response-Related Genes and Diagnostic Biomarkers in Atherosclerosis by Integrative Multidimensional Analysis and Experimental Validation. [PDF]

J Inflamm Res
Wu S, Liu Y, Li Y, Lai J, Wan Q, Wu J, Ma Y.   +6 more
europepmc   +1 more source

Nonthermal Food Processing Technologies: A Comprehensive Review

Future Postharvest and Food, EarlyView.
The graphical abstract illustrates the shift from traditional thermal food preservation methods to advanced nonthermal technologies. Traditional methods, represented by heating, often compromise the nutritional and sensory quality of foods. In contrast, nonthermal approaches such as high‐pressure processing (HPP), pulsed electric field (PEF ...
Ashok Kumar Yadav, Dinesh Chandra Rai, Aman Rathaur, Hradesh Rajput, Sudhir Kumar, Zeenat Aman   +5 more
wiley   +1 more source

AI662270/GRP94 axis couples the unfolded protein response to mitochondrial dynamics during acute myocardial infarction. [PDF]

JCI Insight
Ding S, Liu W, Zhang Z, Yang X, Sun D, Zhu J, Zhu X, Wang S, Xie M, Shi H, Ge J, Yang X.   +11 more
europepmc   +1 more source

Identification and validation of a prognostic model for HER2-low breast cancer based on unfolded protein response-related genes. [PDF]

Discov Oncol
Zhao Y, Gao Y, Yan H, Hu P.
europepmc   +1 more source

The unfolded protein response is a critical mediator in Campylobacter jejuni pathogenesis and host defence

Geunhye Hong, Zahra Omole, Cadi Davies, Janie Liaw, Anna D. Grabowska, Barbara Canonico, Nicolae Corcionivoschi, Brendan W. Wren, Ezra Aksoy, Nick Dorrell, Abdi Elmi, Ozan Gundogdu   +11 more
openalex   +1 more source