Results 281 to 290 of about 1,143,124 (339)

Melatonin Induces PERK-ATF4 Unfolded Protein Response and Apoptosis in Human Choriocarcinoma Cells. [PDF]

J Pineal Res
Bienvenue-Pariseault J, Sagrillo-Fagundes L, Wong-Yen P, Stakamatos D, Cohen M, Vaillancourt C.   +5 more
europepmc   +1 more source

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

RETRACTED: Plant rhabdovirus glycoprotein activates unfolded protein response-mediated antiviral ER-phagy in insect vectors.

PLoS Pathog
Chen S, Cheng Y, Tang Y, Zhang J, Li Y, Jia D, Chen H, Wei T.   +7 more
europepmc   +1 more source

Ufmylation Suppresses Unfolded Protein Response to Prevent Peripartum Cardiomyopathy. [PDF]

JACC Basic Transl Sci
Tandra V, Zhang L, Lee CM, Wu Y, Yue G, Li H, Su H, Li J.   +7 more
europepmc   +1 more source

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Activating GCN2 and subsequently the Unfolded Protein Response with the small oral molecule NXP800 delays tumor growth in osteosarcoma. [PDF]

Cell Death Discov
Racineau E, Lallier M, Postec A, Amiaud J, Thépault RA, Brion R, Battaglia S, Charrier C, Colle MA, Brounais-Le Royer B, Baud'huin M, Verrecchia F, Ory B, Georges S, Lamoureux F.   +14 more
europepmc   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Multi-omics analyses related to unfolded protein response in prostate cancer implicate pro-tumor role of IFRD1. [PDF]

Front Immunol
Xue Y, Huang E, Luo C, Qian Y, Wu T, Chu C, Shi F, Chen S, Zhang D, Chen W, Huang W, Wang P, Chen H, Cheng Y, Fan Y.   +14 more
europepmc   +1 more source

K29-Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response. [PDF]

Adv Sci (Weinh)
Zhang Q, Teng X, Dai Y, Wu Y, Hou H, Li J.   +5 more
europepmc   +1 more source