Results 121 to 130 of about 26,198 (189)

Time in Therapeutic Range of Unfractionated Heparin-Based Therapy in Critically Ill Patients with COVID-19 Pneumonia. [PDF]

Ther Clin Risk Manag
Romanová T, Burša F, Sklienka P, Sagan J, Vaňková M, Buršík D, Bílená M, Pulcer M, Burda M, Máca J.   +9 more
europepmc   +1 more source

Prescriber perceptions of the safety and efficacy of unfractionated heparin versus low molecular weight heparin in the acute treatment phase: a qualitative study. [PDF]

J Pharm Policy Pract
Green D, Edmunds C, Rose'Meyer R, Singh I, Hattingh HL.   +4 more
europepmc   +1 more source

Effect of Unfractionated Heparin Dose on Complement Activation and Selected Extracellular Vesicle Populations during Extracorporeal Membrane Oxygenation. [PDF]

Int J Mol Sci
Zipperle J, Vock L, Fritsch G, Grillari J, Osuchowski MF, Holnthoner W, Schöchl H, Halbgebauer R, Huber-Lang M, Hofmann N, Scharner V, Panigada M, Gratz J, Iapichino G.   +13 more
europepmc   +1 more source

Unfractionated Heparin Safety in COVID-19: Incidence and Risks of Bleeding Complications in Japan. [PDF]

J Atheroscler Thromb
Sato L, Iwamoto N, Kakumoto Y, Tsuzuki S, Togano T, Ishikane M, Okumura N, Yamada G, Inada M, Suzuki T, Hojo M, Takasaki J, Sasaki R, Kimura A, Teruya K, Okamoto T, Hayakawa K, Hara H, Iseki K, Ohmagari N.   +19 more
europepmc   +1 more source

Postoperative anticoagulation management using subcutaneous unfractionated heparin for a patient with nonbacterial thrombotic endocarditis: a case report. [PDF]

J Surg Case Rep
Mine H, Saku K, Takagi K, Nohara S, Hiromatsu S, Fukumoto Y, Tayama E.   +6 more
europepmc   +1 more source

Unfractionated heparin may improve near-term survival in patients admitted to the ICU with sepsis attributed to pneumonia: an observational study using the MIMIC-IV database. [PDF]

Front Pharmacol
Fang S, Wang Y, Nan W, Feng Y, Su W, Wang Y, Jiang X.   +6 more
europepmc   +1 more source

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Unfractionated heparin dosing in obese patients

International Journal of Clinical Pharmacy, 2020
Background The effect of obesity on the pharmacokinetics and pharmacodynamics of unfractionated heparin is not clearly understood, therefore to reduce the risk of bleeding, maximal dose (capped) nomograms are often used. This can lead to inadequate anticoagulation and increased mortality and morbidity.
George, Christopher, Barras, Michael, Coombes, Judith, Winckel, Karl   +3 more
openaire   +5 more sources

Challenges in Variation and Responsiveness of Unfractionated Heparin

Pharmacotherapy, 2004
Unfractionated heparin (UFH) has been in clinical use for more than half a century. Despite its undoubted contribution to the treatment and prevention of thrombosis, heparin is significantly limited by its variable biochemical composition and unpredictable pharmacokinetics.
John L Francis
exaly   +3 more sources

The Use and Limitations of Unfractionated Heparin

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine, 2010
Despite the development of newer anticoagulants, unfractionated heparin remains an indispensible agent in the treatment of thrombotic disorders. Heparin exerts its major effect via antithrombin, converting antithrombin to a more efficient inhibitor of circulating thrombin (factor IIa), factor Xa, factor IXa, factor XIIa, and kallikrein. However, due to
Amar, Krishnaswamy, A Michael, Lincoff, Christopher P, Cannon   +2 more
openaire   +2 more sources