Results 131 to 140 of about 26,198 (189)

Revisiting the Pharmacology of Unfractionated Heparin

Clinical Pharmacokinetics, 2019
Unfractionated heparin (UFH) is a commonly used anticoagulant therapy for the acute treatment and prevention of thrombosis. Its short duration of action, reversibility of effect by protamine sulfate, and extensive clinical experience are some of the advantages that support its use.
Abdallah Derbalah, Stephen Duffull, Fiona Newall, Katie Moynihan, Hesham Al-Sallami   +4 more
openaire   +2 more sources

Bleeding complications of unfractionated heparin

Expert Opinion on Drug Safety, 2010
Unfractionated heparin is an anticoagulant used in the treatment of myocardial infarction, pulmonary embolism and other thrombotic disorders. However, with anticoagulation comes the risk of bleeding and adverse events. These risks increase with supratherapeutic dosing.In this review, we discuss the reasons for supratherapeutic dosing, and the incidence
Amar, Krishnaswamy, A Michael, Lincoff, Christopher P, Cannon   +2 more
openaire   +2 more sources

Unfractionated heparin or low-molecular-weight heparin in the elderly

International Journal of Cardiology, 2016
With the ageing of the general population, clinicians are facing with increased frequency the challenge of administering parenteral anti-coagulation therapy in the elderly, the main indications being venous thromboembolism (VTE), acute coronary syndromes (ACS), atrial fibrillation and bridging therapy.
Maria Dorobantu, Stefan Bogdan
openaire   +2 more sources

Pharmacokinetics of Low Molecular Weight Heparin and Unfractionated Heparin in Pregnancy

Journal of the Society for Gynecologic Investigation, 2004
Little pharmacokinetic data are available for either low molecular weight heparins (LMWHs) or unfractionated heparins (UFHs) in pregnancy. The objectives of this study were to determine whether differences exist in the pharmacokinetics of dalteparin and UFH before and during the first, second, and third trimesters of pregnancy in women with the ...
Mary Stephenson
exaly   +3 more sources

Antithrombotic Activity of Oral Unfractionated Heparin

Journal of Cardiovascular Pharmacology, 1996
Although heparin is believed to be poorly absorbed orally, we recently demonstrated that oral heparin rapidly enters the circulation, with most of the drug being taken up by endothelium. To determine the effective antithrombotic dose of oral heparin, we induced thrombosis by applying 10% formalin in 65% methanol to exposed rat jugular vein.
L M, Hiebert, S M, Wice, L B, Jaques
openaire   +2 more sources

A low molecular weight heparin compared with unfractionated heparin

Thrombosis Research, 1982
A 6000 daltons low molecular weight heparin (LMWH) was compared with unfractionated mucosal heparin in vitro and in vivo. Despite unimpressive specifications by clotting assays in vitro, the LMWH gave high and sustained activity in vivo by anti-Factor Xa assays, following subcutaneous injection.
D P, Thomas, R E, Merton
openaire   +2 more sources

Unfractionated Heparin Therapy in Infants and Children

Pediatrics, 2009
Unfractionated heparin is frequently used in tertiary pediatric centers for the prophylaxis and treatment of thromboembolic disease. Recent evidence suggests that the clinical outcomes of unfractionated heparin therapy in children are poor, as determined by target-range achievement and adverse-event rates.
Newall, F., Johnston, Linda, Ignjatovic, V., Monagle, P.   +3 more
openaire   +3 more sources

Practical prescribing of intravenous unfractionated heparin

British Journal of Hospital Medicine, 2009
Intravenous unfractionated heparin is sometimes poorly managed in NHS hospitals. This article investigates why this is so and reviews the evidence for optimal unfractionated heparin prescribing, using it to make some suggestions as to how doctors can improve this.
Daniel M, Sado, Dallas, Price, Sajiram, Sarvananthan   +2 more
openaire   +2 more sources

Unfractionated Heparin: A Nursing Dilemma

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2004
Nurses face challenges in all aspects of their practice, especially with administering and monitoring drugs in a safe, effective manner. Key factors known to affect drug administration include general drug knowledge, formal nurse education, continuing education needs, clinical experience, and the nationwide nursing shortage.
openaire   +2 more sources

A Severe Case of Idiosyncratic Hepatotoxicity with Unfractionated Heparin

Hospital Pharmacy, 2020
The authors describe a case of clinically apparent idiosyncratic hepatotoxicity in association with unfractionated heparin (UFH). A 52-year-old woman with increasingly symptomatic rheumatic mitral valvular disease and severe pulmonary hypertension underwent elective minimally-invasive bioprosthetic mitral valve replacement.
Jason Samuel Haney, Cassandra Tatum Carter, Jacklyn Downey, Romina Ilic   +3 more
openaire   +2 more sources