Results 71 to 80 of about 26,198 (189)

Thromboprophylaxis in obstetrics: who, when and how [PDF]

Гинекология, 2014
The article highlights the current issues of the use of anticoagulants (unfractionated and low molecular weight heparin) for the prevention of venous thromboembolic complications in obstetric practice.
A V Kulikov, E M Schiffman, I B Zabolotskikh, S V Sinkov, S R Belomestnov   +4 more
doaj  

Design and Implementation of an Automated Interpretation Algorithm for Lupus Anticoagulant Functional Testing

International Journal of Laboratory Hematology, Volume 48, Issue 5, Page 1181-1188, October 2026.
ABSTRACT Introduction Lupus anticoagulant (LA) testing is essential, albeit complex, in the laboratory diagnosis of antiphospholipid syndrome (APS). Given the multi‐step workflow and the variability introduced by anticoagulant therapy, reagent differences, and interpretive approaches, result interpretation requires expert evaluation.
Chiara Novelli, Arianna Gatti, Flora Ierna, Elena Riccardi, Irene Cuppari   +4 more
wiley   +1 more source

Evaluation of the Activated Partial Thromboplastin Time (aPTT) Sensitivity to Unfractionated Heparin Using Three Commercial Reagents: Implication for Therapeutic Range

Siriraj Medical Journal, 2005
At present, we are using the proposed therapeutic range for monitoring unfractionated heparin therapy which is the aPTT ratio of 1.5-2.5. However, the aPTT value is influenced by reagents and methods of detection. The College of American Pathologists and
Nisarat Opartkiattikul, Panutsaya Tientadakul, Wanida Wongtiraporn   +2 more
doaj  

Successful use of fondaparinux for perioperative bridging in a patient with a mechanical heart valve and heparin-induced thrombocytopenia

Journal of Applied Hematology, 2019
The mechanical heart valve prosthesis is a thrombotic state requiring anticoagulation at therapeutic doses. Heparin-induced thrombocytopenia (HIT) is both a thrombotic and bleeding state which has a high chance of recurrence when heparin is reinitiated ...
C R Pruthvi, Krishna Prasad, Dinakar Bootla, V Krishna Santosh, Parag Barwad   +4 more
doaj   +1 more source

Can nebulised heparin reduce acute lung injury in patients with SARS‑CoV‑2 requiring advanced respiratory support in Ireland: the CHARTER‑Ireland phase Ib/IIa, randomised, parallel-group, open-label study

Intensive Care Medicine Experimental
Background Nebulised unfractionated heparin may attenuate COVID-19 ARDS by reducing pulmonary microvascular thrombosis, blocking SARS-CoV-2 entry into cells, and decreasing lung inflammation.
David Cosgrave, Bairbre McNicholas, Ciara Hanley, John Robert Sheehan, Padraig Calpin, Maeve Kernan, Darragh Murphy, Alberto Alvarez‑Iglesias, John Ferguson, Camilla Giacomini, Christine Greene, Catriona Cody, Shane McGeary, Marion Murphy, Marianne Fitzgerald, Gerard Curley, Barry Dixon, Roger J. Smith, Claire Masterson, Daniel O’Toole, Frank van Haren, John G. Laffey   +21 more
doaj   +1 more source

Heparin-induced DRESS syndrome in a paediatric patient and successful anaesthetic management in cardiovascular bypass surgery: case report

Journal of Cardiothoracic Surgery
Background Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome is a severe adverse drug reaction marked by delayed hypersensitivity reactions causing skin and systemic complications. DRESS diagnosis is challenging due to the variety of
Laura Peña-Blanco, Laura Gutiérrez-Soriano, Félix Ramón Montes, Andrea Barragán-Méndez, Susana Beltrán-Villegas, Juan José López-Reyes, Carlos A. Villa-Hincapié, Juan Pablo Umaña   +7 more
doaj   +1 more source

Evaluating Anticoagulant and Antiplatelet Therapies in Rhesus and Cynomolgus Macaques for Predictive Modeling in Humans

Surgeries
Anticoagulant and antiplatelet therapies are used to prevent life-threatening complications associated with thrombosis. While there are numerous clinical guidelines for antithrombotic medications, there is an incomplete understanding of whether these ...
Sydney N. Phu, David J. Leishman, Sierra D. Palmer, Scott H. Oppler, Melanie N. Niewinski, Lucas A. Mutch, Jill S. Faustich, Andrew B. Adams, Robert T. Tranquillo, Melanie L. Graham   +9 more
doaj   +1 more source

The neutralizing effect of heparin on blood-derived antimicrobial compounds: impact on antibacterial activity and inflammatory response

Frontiers in Immunology
Acting through a combination of direct and indirect pathogen clearance mechanisms, blood-derived antimicrobial compounds (AMCs) play a pivotal role in innate immunity, safeguarding the host against invading microorganisms.
Denisa Cont, Denisa Cont, Stephan Harm, Claudia Schildböck, Claudia Kolm, Claudia Kolm, Alexander K. T. Kirschner, Alexander K. T. Kirschner, Andreas H. Farnleitner, Andreas H. Farnleitner, Matthias Pilecky, Matthias Pilecky, Jennifer Zottl, Jens Hartmann, Viktoria Weber   +14 more
doaj   +1 more source

Heparin-like compounds improve the biophysical properties of eosinophilic mucus

Allergology International
Background: In eosinophilic chronic rhinosinusitis (ECRS), eosinophil extracellular traps (EETs) formed via extracellular trap-forming cell death contribute to abnormal mucus properties, including increased viscosity and hydrophobicity, which exacerbate ...
Misaki Arima, Tomoe Abe, Sahoko Kodama, Keisuke Ito, Keinosuke Hizuka, Hiroki Tomizawa, Yui Miyabe, Mineyo Fukuchi, Rossana C.N. Melo, Yoshinori Matsuwaki, Shigeharu Ueki   +10 more
doaj   +1 more source

Low-molecular heparins in thrombolytic therapy of myocardial infarction patients

Кардиоваскулярная терапия и профилактика, 2009
Currently, parenteral anticoagulant therapy is considered a standard addition to thrombolytic treatment (TLT) in myocardial infarction (MI). This review analyses the results of the clinical trials demonstrating the benefits of subcutaneous low-molecular ...
I. S. Yavelov
doaj