Results 51 to 60 of about 26,198 (189)

Life-threatening hemorrhage following subcutaneous heparin therapy

Therapeutics and Clinical Risk Management, 2008
Jana Hudcova, Daniel TalmorDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USAAbstract: Prophylactic administration of unfractionated heparin is a common practice in ...
Jana Hudcova, Daniel Talmor
doaj  

Derivation and Validation of Age- and Body Mass Index-Adjusted Weight-Based Unfractionated Heparin Dosing

Clinical and Applied Thrombosis/Hemostasis, 2019
Unfractionated heparin dosing is unpredictable and subject to numerous pharmacokinetic changes including distribution and metabolic changes associated with obesity and age.
James W. Schurr PharmD, Anne-Marie Muske PharmD, Craig A. Stevens PharmD, Sarah E. Culbreth PharmD, Katelyn W. Sylvester PharmD, Jean M. Connors MD   +5 more
doaj   +1 more source

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1255-1265, November 2026.
Digital patients and in silico clinical trials offer new opportunities to advance pharmacological research, clinical development, and regulatory decision‐making by enabling the simulation of treatment effects prior to testing in patients. Among the most promising of these opportunities is the combined use of quantitative systems pharmacology (QSP) and ...
Thomas Klabunde, Ramon Hernandez, Piet H. van der Graaf, Tommaso Andreani   +3 more
wiley   +1 more source

The “Spiked Helmet Sign” on Electrocardiogram Following Left Ventricular Assist Device Implantation: A Case Report

Annals of Noninvasive Electrocardiology, Volume 31, Issue 6, November 2026.
The Spiked Helmet Sign on electrocardiogram after LVAD implantation serves as a critical early warning of localized pericardial hematoma and impending tamponade. Prompt recognition should trigger immediate echocardiographic evaluation, as demonstrated in this case, to guide urgent management.
Qin Qian, Ling Yin
wiley   +1 more source

Clinical Outcomes of Drug‐Eluting Stents and Drug‐Coated Balloons in Tortuous Small Coronary Lesions

Catheterization and Cardiovascular Interventions, Volume 108, Issue 4, Page 1680-1689, October 1, 2026.
ABSTRACT Background In small, tortuous coronary lesions, the long‐term comparative performance of drug‐coated balloon (DCB) angioplasty versus drug‐eluting stent (DES) treatment remains uncertain, despite both strategies being widely used in contemporary percutaneous coronary intervention (PCI) practice. Aims This study aimed to compare 3‐year clinical
Shunichiro Ishio, Takashi Nagasaka, Ryota Taniuchi, Shiro Amanai, Yohei Ishibashi, Noriaki Takama, Hideki Ishii   +6 more
wiley   +1 more source

Otogenic Sigmoid Sinus Thrombosis Complicated by Cerebellar Abscess and Hydrocephalus: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT A 44‐year‐old man developed otogenic sigmoid sinus thrombosis with cerebellar abscess, hydrocephalus, and recurrent posterior fossa infection. Staged neurosurgical drainage and canal‐wall‐down mastoidectomy achieved source control. Cultures were negative. Anticoagulant exposure was perioperative/early postoperative.
Alexandra Mădălina Bizdu‐Branovici, Luana Gherasie, Irina Gabriela Ionița, Maria Denisa Zica, Andreea Rusescu, Răzvan Hainaroșie, Viorel Zainea   +6 more
wiley   +1 more source

The anti-cancer properties of heparin and its derivatives: a review and prospect

Cell Adhesion & Migration, 2020
Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival.
Sai-Nan Ma, Zhi-Xiang Mao, Yang Wu, Ming-Xing Liang, Dan-Dan Wang, Xiu Chen, Ping-an Chang, Wei Zhang, Jin-Hai Tang   +8 more
doaj   +1 more source

Hypertriglyceridemic Acute Pancreatitis With Concomitant Retrocecal Appendicitis: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Hypertriglyceridemia‐induced acute pancreatitis and acute appendicitis are distinct clinical conditions rarely reported to occur concurrently. We present a case of hypertriglyceridemia‐induced pancreatitis characterized by clinical deterioration despite a decline in serum triglyceride levels.
Mansoureh Shekarchizadeh Esfahani, Masood Shekarchizadeh, Seyed Amirhossein Dormiani Tabatabaei, Mehrnazsadat Dormiani Tabatabaei   +3 more
wiley   +1 more source

Ethylene Glycol Poisoning Without Fomepizole in a Regional Australian Intensive Care Unit: The Lactate Gap as the Diagnostic Key and the Consequences of Nasogastric Ethanol Therapy

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT A 62‐year‐old man presented comatose with pH 6.88 and no ingestion history. A point‐of‐care lactate above 31 mmol/L with a laboratory lactate of 0.8 mmol/L revealed a lactate gap, diagnosing ethylene glycol poisoning despite a near‐normal osmolar gap. High‐dose continuous renal replacement therapy corrected the acidosis; he survived.
Jacob Athans, Prashant Maan
wiley   +1 more source