Results 181 to 190 of about 12,490 (237)

Unilamellar Liposomes with Enhanced Boron Content

Bioconjugate Chemistry, 2005
A new type of boron-rich, DSPC-free, unilamellar liposomes was formed using the novel dual-chain, ionic, nido-carborane lipid, K[nido-7-(C16H33OCH2)2CHOCH2-7,8-C2B9H11] (DAC-16), and cholesterol for encapsulation of an aqueous buffer core. Since DSPC was not necessary for the formation of stable DAC-16 liposomes, the boron concentration of these ...
Tiejun, Li, Julie, Hamdi, M Frederick, Hawthorne   +2 more
openaire   +2 more sources

Making Unilamellar Liposomes Using Focused Ultrasound

Langmuir, 2011
Several techniques are available for making large unilamellar vesicles (LUV) with an average diameter of approximately 100 nm, widely employed as model biomembranes as well as vehicles for drug delivery. Here we describe the use of adaptive focused ultrasound (AFU) for the preparation of LUV from multilamellar vesicles (MLV) and studied the effects of ...
Tejera-Garcia, Roberto, Ranjan, Sanjeev, Zamotin, Vladimir, Sood, Rohit, Kinnunen, Paavo, K.J.   +5 more
openaire   +4 more sources

Extemporaneous preparation of large unilamellar liposomes

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1985
Direct contact between lipids solubilized by octyl glucoside and Amberlite XAD-2 beads yielded large liposomes (240 nm diameter) with no residual detergent molecules, in less than 10 min. This extemporaneous preparation of liposomes was prepared with a detergent/bead ratio no higher than 0.12 (mumol/mg) and a phosphatidylcholine/phosphatidylserine ...
J R, Philippot, S, Mutaftschiev, J P, Liautard   +2 more
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Diffusion and Catalysis Processes in Unilamellar Liposomes

Journal of Liposome Research, 1992
AbstractThis research concerns the study of enzyme loaded unilamellar vesicles as bioreactors. The plant enzyme Ascorbic Acid Oxidase (AAO) was entrapped in unilamellar liposomes.Kinetic study shows that the enzyme activity is largely criptic and that the enzyme in liposomes is partially protected against proteolysis.
ANNESINI MC, DI GIULIO, Antonio, DI MARZIO L, FINAZZI AGRO' A, MOSSA G.   +4 more
openaire   +2 more sources

Predicting hydrophilic drug encapsulation inside unilamellar liposomes

International Journal of Pharmaceutics, 2012
A mathematical model has been developed to predict the encapsulation efficiency of hydrophilic drugs in unilamellar liposomes, and will be useful in formulation development to rapidly achieve optimized formulations. This model can also be used to compare drug encapsulation efficiencies of liposomes prepared via different methods, and will assist in the
Xiaoming, Xu, Mansoor A, Khan, Diane J, Burgess   +2 more
openaire   +2 more sources

Polyelectrolyte-Coated Unilamellar Nanometer-Sized Magnetic Liposomes

Langmuir, 2009
Superparamagnetic nanoparticles were encapsulated in liposomes prior to the stepwise adsorption of polyelectrolytes of opposite charges commonly known as the layer-by-layer (LbL) technique. Magnetic fields allow a fast separation of coated liposomes from unbound polyelectrolytes. The coated particles were characterized by dynamic light scattering (DLS),
Pereira da Silva Gomes, Joana Filipa, Rank, Anja, Kronenberger, Astrid, Fritz, Jürgen, Winterhalter, Mathias, Ramaye, Yannic   +5 more
openaire   +3 more sources

Temperature-dependent permeability of large unilamellar liposomes

Chemistry and Physics of Lipids, 1984
The temperature-dependent drug leakage from liposomes composed of dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol (4:1, by weight) was studied. Experiments were performed in Hepes buffer and 50% fetal calf serum. Large unilamellar liposomes were formed by the reverse phase evaporation process and extruded through a series of ...
R L, Magin, M R, Niesman
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Efficient clodronate entrapment within multilamellar and unilamellar liposomes

Journal of Pharmacological and Toxicological Methods, 1992
Clodronate (dichloromethylene bisphosphonate) encapsulated within liposomes and administered intravenously eliminates resident macrophages within the liver and spleen. Macrophage depletion in the rat requires 20 mg of the encapsulated drug, and so far this has only been achieved using large multilamellar vesicles (MLV).
W G, Love, J P, Camilleri, B D, Williams
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Temperature-Dependent Drug Release from Large Unilamellar Liposomes

Cancer Drug Delivery, 1984
The drug-release properties of large unilamellar liposomes were measured at temperatures near the lipid's phase-transition temperature. The liposomes were formed from a mixture of dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol (4:1 by weight) by the reverse-phase evaporation process.
R L, Magin, M R, Niesman
openaire   +2 more sources

Aggregation of unilamellar lecithin liposomes induced by cyclosporin

Journal of Microencapsulation, 1986
Small unilamellar [14C]lecithin liposomes prepared in the presence of cyclosporin sedimented at 12,000 g. Sepharose 4B gel filtration of the resuspended pellet and supernatant yielded identical peaks consisting of small unilamellar liposomes containing cyclosporin. The column retained 40-50 per cent of 14C-labelled liposomes prepared in the presence of
L, Stuhne-Sekalec, J, Chudzik, N Z, Stanacev   +2 more
openaire   +2 more sources