Results 41 to 50 of about 12,490 (237)

Membrane Semi‐Permeability and Ion Selectivity in Chemiosmosis: Open Systems Volume Dependence of Electrolyte Chemistry

Advanced Materials Interfaces, EarlyView.
Very small cellular compartments can break electroneutrality and harness proton gradients without active transport structures, whereas larger volumes cannot, underscoring why life's critical energy processes are confined in microscopic spaces. ABSTRACT The effect of pH changes in external ionic solutions on liposomes entrapping non‐permeable weak acid ...
Josep M. Ribó, Isabel Herreros, David Hochberg, Federico Morán, Michael Stich   +4 more
wiley   +1 more source

Membrane‐Penetrating Molecular Device Based on a Triplex Containing Acyclic L‐Threoninol Nucleic Acid Functionalized with Cholesterol

Angewandte Chemie, EarlyView.
A membrane‐penetrating molecular device composed of triplex containing cholesterol‐modified acyclic L‐threoninol nucleic acid (L‐aTNA) was achieved. This device is applied to a photo‐triggered signal transduction system functioning on giant unilamellar vesicles. Abstract Membrane‐penetrating molecular devices are valuable biological tools.
Kaifu Liu, Hiroyuki Asanuma, Keiji Murayama   +2 more
wiley   +2 more sources

Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity

Foods, 2023
Monascus red pigments (MRPs), which are a kind of natural colorant produced by Monascus spp., are widely used in the food and health supplements industry but are not very stable during processing and storage.
Pengcheng Long, Lisha Zhu, Huafa Lai, Suyin Xu, Xingxing Dong, Yanchun Shao, Liling Wang, Shuiyuan Cheng, Gang Liu, Jingren He, Yi He   +10 more
doaj   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Niosome as a promising tool for increasing the effectiveness of anti-inflammatory compounds

EXCLI Journal : Experimental and Clinical Sciences
Niosomes are drug delivery systems with widespread applications in pharmaceutical research and the cosmetic industry. Niosomes are vesicles of one or more bilayers made of non-ionic surfactants, cholesterol, and charge inducers.
Mohammad Saleh Fadaei, Mohammad Reza Fadaei, Amir Emad Kheirieh, Pouria Rahmanian-Devin, Mohammad Mahdi Dabbaghi, Kiarash Nazari Tavallaei, Abouzar Shafaghi, Hooman Hatami, Vafa Baradaran Rahimi, Ali Nokhodchi, Vahid Reza Askari   +10 more
doaj   +1 more source

Cholesterol protects phosphatidylcholine liposomes from N,N-dimethyldodekanamine N-oxide influence

Acta Chimica Slovenica, 2015
The interaction of N,N-dimethyldodekanamine N-oxide (C12(CH3)2NO) with egg yolk phosphatidylcholine (EYPC) liposomes containing cholesterol (CHOL) in molar ratios nCHOL:nEYPC = 0-0,8 was studied.
Silvia Huláková, Jana Gallová, Ferdinand Devínsky   +2 more
doaj   +1 more source

A nano-Liposomal formulation potentiates antioxidant, anti-inflammatory, and fibrinolytic activities of Allolobophora caliginosa coelomic fluid: formulation and characterization

BMC Biotechnology, 2023
Background Coelomic fluid, a pharmacologically active compound in earthworms, exhibits a range of biological activities, including antioxidant, anti-inflammatory, and anticancer.
Asmaa E. Farouk, Sohair R. Fahmy, Amel M. Soliman, Sherif Abdelaziz Ibrahim, Shimaa A. Sadek   +4 more
doaj   +1 more source

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

Advanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta, Mette Galsgaard Malle, Emily Tsang, Marjan Omer, Mads K. Skaanning, Sarah Youssef, Jørgen Kjems, Kurt V. Gothelf   +7 more
wiley   +1 more source

Liposome Disruption Assay to Examine Lytic Properties of Biomolecules

Bio-Protocol, 2017
Proteins may have three dimensional structural or amino acid features that suggest a role in targeting and disrupting lipids within cell membranes. It is often necessary to experimentally investigate if these proteins and biomolecules are able to disrupt
John Jimah, Paul Schlesinger, Niraj Tolia   +2 more
doaj   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source