Results 71 to 80 of about 151,969 (265)

First report of an HIV-1 triple recombinant of subtypes B, C and F in Buenos Aires, Argentina

Retrovirology, 2006
We describe the genetic diversity of currently transmitted strains of HIV-1 in men who have sex with men (MSM) in Buenos Aires, Argentina between 2000 and 2004.
Weissenbacher Mercedes, Sánchez José L, Montano Silvia M, Marone Rubén, Ceballos Ana, Bautista Christian T, Segura Marcela, Eyzaguirre Lindsay M, Pando María A, Ávila María M, Carr Jean K   +10 more
doaj   +1 more source

Types and mosaic pattern of HIV-1 unique recombinant forms identified in Sweden.

, 2014
A. Proportion of recombinant forms was identified based on REGAv3, COMET and RIP 3.0 followed by bootscan analysis incorporated in REGAv3 and SimPlot analysis. B. Mosaic pattern of URFs identified by REGAv3 and SimPlot.
Jan Albert (176517), Göran Bratt (176495), Anders Sonnerborg (5659342), Ujjwal Neogi (286198), Amanda Häggblom (393667), Michele Santacatterina (553721), Magnus Gisslén (176506)   +6 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Current trends of HIV recombination worldwide

Infectious Disease Reports, 2013
One of the major characteristics of HIV-1 is its high genetic variability and extensive heterogeneity. This characteristic is due to its molecular traits, which in turn allows it to vary, recombine, and diversify at a high frequency.
Katherine A. Lau, Justin J.L. Wong
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

[A new unique HIV-1 recombinant form detected in Belarus].

Voprosy virusologii, 2012
Republican Research-and-Practical Center for Epidemiology and Microbiology, Ministry of Health of Belarus, Minsk The paper presents data on the molecular genetic characteristics of a new HIV-1 recombinant form. The study has shown that the virus is referred to as HIV-1 subtype B in terms of the gag gene and HIV-1 subtype A in terms of the pol and env ...
V F, Eremin, E L, Gasich, S V, Sosinovich   +2 more
openaire   +1 more source

HIV-1 subtype diversity and transmission strain source among men who have sex with men in Guangxi, China

Scientific Reports, 2021
With the rapid increase in HIV prevalence of men who have sex with men (MSM) in recent years and common human migration and travelling across different provinces in China, MSM are now finding it easier to meet each other, which might contribute to local ...
Yi Chen, Zhiyong Shen, Yi Feng, Yuhua Ruan, Jianjun Li, Shuai Tang, Kailing Tang, Shujia Liang, Xianwu Pang, Edward B. McNeil, Hui Xing, Virasakdi Chongsuvivatwong, Mei Lin, Guanghua Lan   +13 more
doaj   +1 more source

Molecular characterisation of recombinant human pyroglutamyl peptidase (type I) [PDF]

, 2005
Pyroglutamyl Peptidase I (PAP1, EC 3.4.19.3) hydrolytically cleaves pyroglutamic acid (pGlu) from the N-terminal of most pGlu-peptides. In higher organisms Thyrothropin Releasing Hormone is a notable biologically active substrate of PAP1. The sequence of
Vaas, Paul-Roman
core  

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source