Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Weak solutions for quasilinear degenerate parabolic systems
Electronic Journal of Differential Equations, 2006 This paper concerns the initial Dirichlet boundary-value problem for a class of quasilinear degenerate parabolic systems. Due to the degeneracies, the problem does not have classical solutions in general.
Zheng'an Yao, Wenshu Zhou
doaj
Endocrinology in Thailand: Unique challenges, unique solutions
Indian Journal of Endocrinology and Metabolism, 2011 Thailand is a developing country in Southeast Asia with a nationally acknowledged requirement for improvement of the medical system. At present, endocrinology is a specific branch of medicine that is taught in few medical schools. There are very few endocrinologists in Thailand, who are unable to cope with the large number of patients with ...
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FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Қарағанды университетінің хабаршысы. Математика сериясыIn the paper the second boundary value problem in a rectangular domain for an inhomogeneous third-order partial differential equation with multiple characteristics with constant coefficients was considered.
Ю.П. Апаков, Р.А. Умаров
doaj +1 more source
Unique Octupolar 2D‐Polymer Frameworks as Mixed Conductors and Metal‐Free Catalysts for Dual‐Promoted Li and S Electrochemistry: Multi‐regulation Role of Ethoxylation Chemistry [PDF]
, 2023 Cong Liu +9 more
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Endocrinology in Nepal: Unique challenges, unique solutions
Indian Journal of Endocrinology and Metabolism, 2011 Nepal has a high prevalence of various endocrine diseases, which is a challenge for its endocrinologists. This article reviews the unique features and trends of endocrine disease, including diabetes, in Nepal. It focuses on the challenges and solutions that endocrine care providers face in the country.
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Unicity Results Concerning of difference monomials of L-function and a meromorphic function
Ratio MathematicaIn this paper, we study the value distribution of $\mathcal{L}$-function in the extend Selberg class and a non-constant transcendental meromorphic $\mathsf{f}$ function with finitely many zeros of finite order, sharing a polynomial with its difference ...
Harina Waghamore P, Roopa M.
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Emergency Foot Fillet Free Flap Based on Posterior Tibial Vessels for Reconstruction of Contralateral Heel and Sole: A Unique Spare Part Surgery [PDF]
, 2022 Hari Venkatramani +4 more
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